POLR2I and TBCD

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		POLR2I	TBCD
Gene Name		polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa	tubulin folding cofactor D
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex	Cytoplasm Microtubule Adherens Junction Tight Junction Lateral Plasma Membrane
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Zinc Ion Binding	GTPase Activator Activity Protein Binding Beta-tubulin Binding Chaperone Binding
	Biological Process	MRNA Splicing, Via Spliceosome Maintenance Of Transcriptional Fidelity During DNA-templated Transcription Elongation From RNA Polymerase II Promoter DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Gene Expression Viral Process PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Viral Transcription	Protein Folding Post-chaperonin Tubulin Folding Pathway Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Microtubule Polymerization Adherens Junction Assembly Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Transmembrane Transport Tight Junction Assembly
Pathways		RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	Protein folding Post-chaperonin tubulin folding pathway Orphan transporters
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: POLR2A POLR2H TBCD	11 interactors: ACD APP ARL2 DEXI POLR2I POT1 SMAD9 TBCE TERF1 TUBB XRCC6
Entrez ID		5438	6904
HPRD ID		15944	05227
Ensembl ID		ENSG00000105258	ENSG00000141556
Uniprot IDs		P36954	J3KR97 Q9BTW9
PDB IDs
Enriched GO Terms of Interacting Partners?		7-methylguanosine MRNA Capping PiRNA Metabolic Process 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Nucleotide-excision Repair Stem Cell Maintenance Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Transcription, RNA-templated DNA-templated Transcription, Initiation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Stem Cell Development Post-chaperonin Tubulin Folding Pathway Stem Cell Differentiation RNA Splicing MRNA Processing NcRNA Metabolic Process MRNA Metabolic Process Viral Process RNA Processing Negative Regulation Of Microtubule Polymerization DNA Repair Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Negative Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Regulation Of Microtubule Polymerization Cellular Response To DNA Damage Stimulus Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase I Promoter Positive Regulation Of RNA Splicing Adherens Junction Assembly DNA Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Transcription From RNA Polymerase III Promoter Tight Junction Assembly Negative Regulation Of Cell-substrate Adhesion 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Regulation Of Microtubule Polymerization Or Depolymerization	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Telomere Assembly Telomere Capping Positive Regulation Of Telomerase Activity Negative Regulation Of Chromosome Organization Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Microtubule Polymerization Positive Regulation Of Cellular Biosynthetic Process Regulation Of DNA Replication Positive Regulation Of DNA Biosynthetic Process DNA Metabolic Process RNA-dependent DNA Replication Cellular Component Assembly Negative Regulation Of DNA Biosynthetic Process Organelle Organization Regulation Of Microtubule Polymerization Regulation Of Chromosome Organization Telomere Maintenance Via Telomere Lengthening Homeostatic Process Microtubule-based Process Negative Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of DNA Replication Regulation Of Organelle Organization Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Maintenance Of Transcriptional Fidelity During DNA-templated Transcription Elongation From RNA Polymerase II Promoter DNA Duplex Unwinding Response To Stimulus DNA Geometric Change Positive Regulation Of Organelle Organization Chromosome Organization Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Synaptic Growth At Neuromuscular Junction Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process
Tagcloud ?			behnke biomicroscopic bucklers corneal dilated dystrophies dystrophy families fundus gcd1 gcd2 granular inheritance inspection korean l527r lattice lcd opacities ophthalmologic p527r p542r r124c r124h r555q refractive reis tgfbi thiel
Tagcloud (Difference) ?			behnke biomicroscopic bucklers corneal dilated dystrophies dystrophy families fundus gcd1 gcd2 granular inheritance inspection korean l527r lattice lcd opacities ophthalmologic p527r p542r r124c r124h r555q refractive reis tgfbi thiel
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