POLR2I

Gene Name		polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Zinc Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Maintenance Of Transcriptional Fidelity During DNA-templated Transcription Elongation From RNA Polymerase II Promoter DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Gene Expression Viral Process PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Viral Transcription
Pathways		RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: POLR2A POLR2H TBCD
Entrez ID		5438
HPRD ID		15944
Ensembl ID		ENSG00000105258
Uniprot IDs		P36954
PDB IDs
Enriched GO Terms of Interacting Partners?		7-methylguanosine MRNA Capping PiRNA Metabolic Process 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Nucleotide-excision Repair Stem Cell Maintenance Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Transcription, RNA-templated DNA-templated Transcription, Initiation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Stem Cell Development Post-chaperonin Tubulin Folding Pathway Stem Cell Differentiation RNA Splicing MRNA Processing NcRNA Metabolic Process MRNA Metabolic Process Viral Process RNA Processing Negative Regulation Of Microtubule Polymerization DNA Repair Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Negative Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Regulation Of Microtubule Polymerization Cellular Response To DNA Damage Stimulus Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase I Promoter Positive Regulation Of RNA Splicing Adherens Junction Assembly DNA Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Transcription From RNA Polymerase III Promoter Tight Junction Assembly Negative Regulation Of Cell-substrate Adhesion 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Regulation Of Microtubule Polymerization Or Depolymerization
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