TARS and HARS

Number of citations of the paper that reports this interaction (PMID 8049265)
1

Data Source:
HPRD (in vitro, in vivo)

		TARS	HARS
Gene Name		threonyl-tRNA synthetase	histidyl-tRNA synthetase
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Actin Cytoskeleton Extracellular Vesicular Exosome	Cytoplasm Cytosol
	Molecular Function	Threonine-tRNA Ligase Activity ATP Binding Protein Homodimerization Activity	Histidine-tRNA Ligase Activity ATP Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Threonyl-tRNA Aminoacylation Gene Expression	Translation TRNA Aminoacylation For Protein Translation Histidyl-tRNA Aminoacylation Gene Expression
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	Cytosolic tRNA aminoacylation tRNA Aminoacylation
Drugs		L-Threonine	L-Histidine
Diseases
GWAS
Protein-Protein Interactions		5 interactors: BRCA1 C7orf25 HARS NDRG1 TARSL2	6 interactors: EEF1B2 EEF1G EIF3I RPL5 TARS TNIK
Entrez ID		6897	3035
HPRD ID		01762	00827
Ensembl ID		ENSG00000113407	ENSG00000170445
Uniprot IDs		P26639	B3KWE1 B4DDD8 B4E1C5 P12081
PDB IDs		1WWT 4HWT	1X59 2LW7 4G84 4G85
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage TRNA Aminoacylation For Protein Translation TRNA Aminoacylation Signal Transduction By P53 Class Mediator Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Carboxylic Acid Metabolic Process Positive Regulation Of Histone H3-K9 Acetylation Histidyl-tRNA Aminoacylation Organic Acid Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation Of Cell Cycle Process TRNA Metabolic Process Threonyl-tRNA Aminoacylation Cellular Response To Indole-3-methanol Positive Regulation Of Cell Cycle Negative Regulation Of Centriole Replication Positive Regulation Of Spindle Checkpoint Dosage Compensation By Inactivation Of X Chromosome Protein K6-linked Ubiquitination Regulation Of Histone H3-K9 Acetylation Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Positive Regulation Of Cell Cycle Checkpoint Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction Resulting In Transcription Cellular Amino Acid Metabolic Process NcRNA Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Histone Methylation Negative Regulation Of Centrosome Duplication Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Positive Regulation Of Histone Acetylation Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Peripheral Nervous System Myelin Maintenance Negative Regulation Of Protein Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Small Molecule Metabolic Process Positive Regulation Of Protein Acetylation Postreplication Repair Regulation Of Transcription From RNA Polymerase III Promoter	Translation Translational Elongation Cellular Protein Metabolic Process Protein Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Threonyl-tRNA Aminoacylation Translational Initiation Biosynthetic Process Activation Of JNKK Activity Ribonucleoprotein Complex Biogenesis Protein Localization To Membrane Microvillus Assembly Microvillus Organization
Tagcloud ?		bed biosolids c6h6 calibrated ch4 char co2 devolatilization disposal drying equivalence fluidized fuel gaseous gases gasification gasifier gasifiers h2 h2o land mathematical offering recover reserved sewage sludge syngas unburned	ascertain botulinum cgi clinician compulsive dysphonia ghq hamilton hdrs impression obsessive pathologist psychometrics psychoticism ql rated rating reevaluated sds somatization somatoform spasmodic speech subscales toxin unilaterally vocal voice zung
Tagcloud (Difference) ?		bed biosolids c6h6 calibrated ch4 char co2 devolatilization disposal drying equivalence fluidized fuel gaseous gases gasification gasifier gasifiers h2 h2o land mathematical offering recover reserved sewage sludge syngas unburned	ascertain botulinum cgi clinician compulsive dysphonia ghq hamilton hdrs impression obsessive pathologist psychometrics psychoticism ql rated rating reevaluated sds somatization somatoform spasmodic speech subscales toxin unilaterally vocal voice zung
Tagcloud (Intersection) ?