TARS1 and HARS1

Number of citations: 0 (PubMedID 8049265)
Data Source: HPRD (in vivo, in vitro)

		TARS1	HARS1
Name		threonyl-tRNA synthetase 1	histidyl-tRNA synthetase 1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	TRNA Binding Nucleotide Binding RNA Binding Aminoacyl-tRNA Ligase Activity Threonine-tRNA Ligase Activity Protein Binding ATP Binding Zinc Ion Binding Ligase Activity Identical Protein Binding	Nucleotide Binding RNA Binding Aminoacyl-tRNA Ligase Activity Histidine-tRNA Ligase Activity ATP Binding Ligase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Threonyl-tRNA Aminoacylation TRNA Aminoacylation	Translation TRNA Aminoacylation For Protein Translation Histidyl-tRNA Aminoacylation
Pathways		Cytosolic tRNA aminoacylation	Cytosolic tRNA aminoacylation
Drugs		Threonine	Histidine
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		9 interacting genes: BRCA1 C7orf25 CEBPA DSCR9 HARS1 HSPB1 LINC01554 NDRG1 RNF10	10 interacting genes: EEF1B2 EEF1G MTNR1B OGT PSMC5 RPL5 TARS1 TNIK TTC3 WEE2-AS1
Entrez ID		6897	3035
HPRD ID		01762	00827
Ensembl ID		ENSG00000113407	ENSG00000170445
Uniprot IDs		P26639	B4DDD8 B4E1C5 P12081
PDB IDs		1WWT 4HWT 4P3N 4TTV 5XLN	1X59 2LW7 4G84 4G85 4PHC 4X5O 5W6M 6O76 8YOR 8YP1
GO Terms Enriched among Interactors		None	Translation Protein Metabolic Process Translation Elongation Factor Activity Translational Elongation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Macromolecule Metabolic Process Macromolecule Biosynthetic Process Nuclear Proteasome Complex Regulation Of Proteolysis Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Eukaryotic Translation Elongation Factor 1 Complex Cytosol Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Proteasome-activating Activity Cytosolic Proteasome Complex Thyrotropin-releasing Hormone Receptor Binding Positive Regulation Of Inclusion Body Assembly Negative Regulation Of Proteolysis Cytoplasmic Translation Positive Regulation Of Translation Negative Regulation Of Protein Neddylation Threonine-tRNA Ligase Activity Threonyl-tRNA Aminoacylation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Microvillus Assembly Pre-mRNA 5'-splice Site Binding Extracellular Exosome Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Carbon Catabolite Regulation Of Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process MRNA 5'-splice Site Recognition