TAL2 and HLA-DQA1

Data Source: HiPPIP (Novel)

		TAL2	HLA-DQA1
Name		TAL bHLH transcription factor 2	major histocompatibility complex, class II, DQ alpha 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Post-embryonic Development Thalamus Development Midbrain Development Multicellular Organism Growth	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation
Pathways		None	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling
Diseases		None	Systemic lupus erythematosus Graves' disease Hashimoto's thyroiditis Dilated cardiomyopathy (DCM) Type I diabetes mellitus
GWAS		Cognitive performance ( 20125193 ) Cutaneous malignant melanoma ( 26237428 ) Melanoma ( 28212542 ) Menarche (age at onset) ( 19448620 ) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738 )	A body shape index ( 34021172 ) Adult asthma ( 30578877 ) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081 ) Alanine aminotransferase levels ( 33547301 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011 ) Allergic rhinitis ( 30013184 ) Allergic sensitization ( 23817571 ) Allergy ( 27182965 ) Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG levels ( 32737300 ) Anti-polyomavirus 2 IgG seropositivity ( 33204752 ) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757 ) Apolipoprotein B levels ( 32203549 ) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 33768542 ) Aspartate aminotransferase levels ( 33339817 33547301 ) Asthma ( 23181788 27182965 29273806 30929738 31361310 31619474 31959851 32296059 34103634 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Asthma (moderate or severe) ( 30552067 ) Asthma (time to onset) ( 27130862 ) Asthma and major depressive disorder ( 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atopic dermatitis ( 26482879 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Autoimmune hepatitis in primary sclerosing cholangitis ( 28779025 ) Autoimmune hepatitis type-1 ( 24768677 ) Autoimmune thyroid disease ( 32581359 ) Basal cell carcinoma ( 31174203 33549134 ) Body mass index ( 28892062 ) C-reactive protein levels ( 30388399 ) Celiac disease ( 17558408 20190752 ) Cervical cancer ( 23482656 28806749 ) Cervical intraepithelial neoplasia grade 3 ( 33794208 ) Cervical intraepithelial neoplasia grade 3 and invasive cervical cancer ( 33794208 ) Childhood asthma with severe exacerbations ( 33328473 ) Childhood ear infection ( 27182965 28928442 ) Childhood steroid-sensitive nephrotic syndrome ( 29903748 31263063 ) Chronic hepatitis C infection ( 24376798 ) Chronic lymphocytic leukemia ( 21131588 ) Chronic obstructive pulmonary disease ( 33909500 ) Chronic rhinosinusitis ( 30643255 ) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107 ) Creatinine levels ( 29403010 ) Crohn's disease ( 23266558 23850713 26891255 ) Cutaneous lupus erythematosus ( 25827949 ) Cutaneous squamous cell carcinoma ( 32041948 ) Drug-induced liver injury (flucloxacillin) ( 30661239 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Eosinophil count ( 32888494 ) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262 29868224 ) Epstein Barr virus nuclear antigen 1 IgG seropositivity ( 29868224 ) Epstein-Barr virus EBNA-1 antibody levels ( 33204752 ) Epstein-Barr virus immune response (multivariate analysis) ( 29868224 ) Epstein-Barr virus VCA p18 antibody levels ( 33204752 ) Epstein-Barr virus ZEBRA antibody levels ( 33204752 ) Estimated glomerular filtration rate ( 30604766 ) Factor VIII levels ( 30586737 ) Giant cell arteritis ( 25817017 28041642 ) Glomerular filtration rate ( 29403010 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Hand grip strength ( 29691431 ) Hematocrit ( 27863252 ) Hemoglobin levels ( 32327693 ) Hepatocellular carcinoma ( 22807686 ) High density lipoprotein cholesterol levels ( 29403010 ) Hip circumference adjusted for BMI ( 34021172 ) Human herpes virus 6 IE1A antibody levels ( 33204752 ) Human herpes virus 7 U14 antibody levels ( 33204752 ) Hypothyroidism ( 22493691 27182965 ) Idiopathic membranous nephropathy ( 21323541 ) IgA nephropathy ( 25305756 26028593 ) Immune response to anthrax vaccine ( 22658931 ) Immunoglobulin A vasculitis ( 28698626 ) Immunoglobulin G index levels in multiple sclerosis ( 25616667 ) Inflammatory bowel disease ( 18758464 28008999 28067908 ) Intraocular pressure ( 29785010 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Keratinocyte cancer (MTAG) ( 31174203 ) Late-onset myasthenia gravis ( 26562150 ) Leishmaniasis (visceral) ( 23291585 ) Leprosy ( 32421744 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 31577861 ) Lymphocyte count ( 29403010 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Lymphoma ( 23349640 ) Mean corpuscular hemoglobin ( 32888494 ) Medication use (adrenergics, inhalants) ( 31015401 ) Medication use (glucocorticoids) ( 31015401 ) Membranous nephropathy ( 27333618 ) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430 ) Monocyte percentage of white cells ( 32888494 ) Multiple sclerosis (OCB status) ( 23472185 ) Myasthenia gravis ( 25643325 ) Myositis ( 26291516 ) Nasal polyps ( 30643255 ) Nephropathy ( 21399633 ) Neuroblastoma or malignant cutaneous melanoma ( 31605138 ) Neuromyelitis optica ( 29769526 32792643 ) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Oligoclonal band status in multiple sclerosis ( 25616667 ) Oropharynx cancer ( 32276964 ) Parental lifespan ( 29030599 30642433 ) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965 ) Parental longevity (mother's attained age) ( 29227965 ) Parkinson's disease ( 27182965 28892059 ) Peanut allergy ( 25710614 ) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575 ) Plantar warts ( 28928442 ) Pneumonia ( 28928442 ) Primary biliary cirrhosis ( 22961000 ) Primary sclerosing cholangitis ( 23603763 ) Prostate cancer ( 23535732 ) Red blood cell count ( 27863252 ) Refractive error ( 32231278 ) Response to hepatitis B vaccine ( 29534301 ) Response to interferon beta therapy ( 21502966 ) Rheumatoid arthritis ( 18668548 23918589 ) Rheumatoid arthritis (ACPA-negative) ( 24532677 ) Rosacea symptom severity ( 29771307 ) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848 ) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848 ) Scarlet fever ( 28928442 ) Schizophrenia ( 19571809 23212062 ) Selective IgA deficiency ( 27723758 ) Self-reported allergy ( 23817569 ) Serum alkaline phosphatase levels ( 33547301 ) Severe autoimmune type 2 diabetes ( 34737425 ) Shingles ( 28928442 ) Sjögren's syndrome ( 24097066 24097067 28076899 ) Small cell lung carcinoma ( 28604730 ) Squamous cell carcinoma ( 26829030 31174203 ) Squamous cell lung carcinoma ( 28604730 ) Strep throat ( 28928442 ) Systemic lupus erythematosus ( 18204098 21408207 24871463 26316170 26606652 32771030 ) Systemic sclerosis ( 21779181 ) Takayasu arteritis ( 25604533 ) Thyroid stimulating hormone levels ( 32769997 ) Tonsillectomy ( 28928442 ) Total bilirubin levels ( 29403010 ) Triglyceride levels ( 32203549 ) Tuberculosis ( 28928442 ) Type 1 diabetes (age at diagnosis) ( 33179336 ) Type 2 diabetes ( 28566273 ) Ulcerative colitis ( 19122664 21297633 23128233 23511034 24837172 26278503 28008999 28067908 ) Urate levels ( 31578528 ) Varicella zoster virus glycoproteins E and I antibody levels ( 33204752 ) Vitiligo ( 20410501 27723757 ) Vogt-Koyanagi-Harada syndrome ( 25108386 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 )
Novel Interactors		2 novel interactors: CDK6 HLA-DQA1	6 novel interactors: BRD2 HLA-DPB1 HLA-DQA2 KLHDC3 NXF1 TAL2
Interacting Genes		9 interacting genes: CBFA2T2 LMO1 LMO2 MAPK3 PCBD2 RUNX1T1 TCF12 TCF3 TCF4	9 interacting genes: APLP1 CD74 CDK7 HLA-DQB1 IKBKG LRIF1 SH3GL2 TLE1 UNC119
Entrez ID		6887	3117
HPRD ID		01735	06765
Ensembl ID		ENSG00000186051	ENSG00000196735
Uniprot IDs		Q16559	A0A173ADG5 A0A346FLH4 A0A649ZVH5 L8E864 P01909 Q5Y7C6 Q5Y7H0 Q8MH44
PDB IDs		Not available	1JK8 1S9V 1UVQ 2NNA 3PL6 4D8P 4GG6 4OZF 4OZG 4OZH 4OZI 5KS9 5KSA 5KSB 5KSU 5KSV 6MFF 6MFG 6U3M 6U3N 6XP6 7SG0 7SG1 7SG2 8VSP 8W83 8W84 8W85 8W86
GO Terms Enriched among Interactors		DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process BHLH Transcription Factor Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process E-box Binding Transcription Regulator Complex Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Neuron Differentiation Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein Dimerization Activity Regulation Of Metabolic Process Regulation Of Neuron Differentiation Regulation Of Lymphocyte Activation Positive Regulation Of Metabolic Process Regulation Of Cell Activation Nucleoplasm Cyclin D2-CDK6 Complex Regulation Of Leukocyte Proliferation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Glial Cell Development Negative Regulation Of RNA Metabolic Process Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Protein Heterodimerization Activity Cis-regulatory Region Sequence-specific DNA Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Cell Differentiation Regulation Of Immune System Process Regulation Of T Cell Activation Regulation Of T Cell Homeostatic Proliferation Interleukin-34-mediated Signaling Pathway Beta-catenin-TCF7L2 Complex Vitamin D Response Element Binding	MHC Class II Protein Complex Clathrin-coated Endocytic Vesicle Membrane MHC Class II Protein Complex Binding Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Transport Vesicle Membrane ER To Golgi Transport Vesicle Membrane Antigen Processing And Presentation Of Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex Endocytic Vesicle Membrane Antigen Processing And Presentation Trans-Golgi Network Membrane Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Peptide Antigen Binding Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion MHC Class II Receptor Activity Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Immune Response Adaptive Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Golgi Membrane Regulation Of Cell Activation Lysosomal Membrane Antigen Receptor-mediated Signaling Pathway Late Endosome Membrane Endosome Protein-containing Complex Assembly Regulation Of Cell Adhesion Lysosome Alpha-2B Adrenergic Receptor Binding MHC Class II Protein Binding, Via Antigen Binding Groove Protein-containing Complex Organization NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway