TACR3 and TAC4

Number of citations of the paper that reports this interaction (PubMedID 11786503)
32

Data Source:
HPRD (in vivo, in vitro)

		TACR3	TAC4
Description		tachykinin receptor 3	tachykinin precursor 4
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Membrane Neuronal Cell Body Membrane Sperm Midpiece	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Tachykinin Receptor Activity Protein Binding	Substance P Receptor Binding Substance K Receptor Binding Receptor Ligand Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Positive Regulation Of Heart Rate Response To Estradiol Regulation Of Dopamine Metabolic Process Response To Cocaine Positive Regulation Of Blood Pressure Regulation Of Feeding Behavior Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility	Negative Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Regulation Of Blood Pressure Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Sensory Perception Of Pain Positive Regulation Of Flagellated Sperm Motility Negative Regulation Of Sensory Perception Of Pain Positive Regulation Of Sensory Perception Of Pain
Pathways		Tachykinin receptors bind tachykinins G alpha (q) signalling events
Drugs		Osanetant Talnetant Pavinetant
Diseases		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Chronotype ( 30696823) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Menarche (age at onset) ( 25231870 27182965) Rosacea symptom severity ( 29771307) Spontaneous preterm birth without premature rupture of membranes ( 31194736)	Femur bone mineral density x serum urate levels interaction ( 34046847) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		4 interacting genes: GPRASP1 TAC1 TAC3 TAC4	3 interacting genes: TACR1 TACR2 TACR3
Entrez ID		6870	255061
HPRD ID		01209	09701
Ensembl ID		ENSG00000169836	ENSG00000176358
Uniprot IDs		P29371	Q86UU9
PDB IDs		8JBF 8JBG 8JBH	2MOC
Enriched GO Terms of Interacting Partners?		Substance K Receptor Binding Tachykinin Receptor Signaling Pathway Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Substance P Receptor Binding Neuromedin K Receptor Binding Regulation Of Cilium Movement Regulation Of Microtubule-based Movement Positive Regulation Of Sensory Perception Of Pain Positive Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Blood Pressure Regulation Of Sensory Perception Of Pain Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Negative Regulation Of Systemic Arterial Blood Pressure Detection Of Temperature Stimulus Regulation Of Microtubule-based Process Negative Regulation Of Blood Pressure Neuropeptide Signaling Pathway Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Nervous System Process Detection Of Abiotic Stimulus Receptor Ligand Activity G Protein-coupled Receptor Catabolic Process Detection Of Stimulus Involved In Sensory Perception Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Temperature Stimulus G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Corticosterone Secretion Negative Regulation Of Sensory Perception Of Pain Insemination Regulation Of Corticosterone Secretion Regulation Of Cell Motility Positive Regulation Of Synaptic Transmission, Cholinergic Detection Of Stimulus Regulation Of Locomotion Positive Regulation Of Action Potential Antifungal Humoral Response Negative Regulation Of Heart Rate Response To Yeast Positive Regulation Of Synaptic Transmission, GABAergic Response To Pain Extracellular Space Receptor Catabolic Process Negative Regulation Of Nervous System Process Negative Regulation Of Heart Contraction Neuronal Dense Core Vesicle	Tachykinin Receptor Activity Positive Regulation Of Uterine Smooth Muscle Contraction Tachykinin Receptor Signaling Pathway Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Positive Regulation Of Smooth Muscle Contraction Regulation Of Cilium Movement Positive Regulation Of Muscle Contraction Sperm Midpiece Regulation Of Microtubule-based Movement Regulation Of Smooth Muscle Contraction Positive Regulation Of Reproductive Process Operant Conditioning Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Muscle Contraction Sperm Head Regulation Of Reproductive Process Positive Regulation Of Vascular Permeability Regulation Of Muscle System Process Regulation Of Microtubule-based Process Positive Regulation Of Blood Pressure G Protein-coupled Receptor Activity Response To Electrical Stimulus Regulation Of Vascular Permeability Smooth Muscle Contraction Regulation Of System Process Positive Regulation Of Cell Motility Positive Regulation Of Locomotion G Protein-coupled Receptor Signaling Pathway Response To Estradiol Sperm Flagellum Substance K Receptor Activity Substance P Receptor Activity Regulation Of Cell Motility Positive Regulation Of Synaptic Transmission Regulation Of Locomotion Learning Regulation Of Blood Pressure Angiotensin-mediated Drinking Behavior Muscle Contraction Prolactin Secretion Negative Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Smooth Muscle Contraction Involved In Micturition Regulation Of Hormone Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Muscle System Process Intestine Smooth Muscle Contraction
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