TAC4 and TACR2

Number of citations of the paper that reports this interaction (PubMedID 11786503)
32

Data Source:
HPRD (in vitro, in vivo)

		TAC4	TACR2
Description		tachykinin precursor 4	tachykinin receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Membrane Sperm Flagellum Sperm Head Sperm Midpiece
	Molecular Function	Substance P Receptor Binding Substance K Receptor Binding Receptor Ligand Activity	G Protein-coupled Receptor Activity Tachykinin Receptor Activity Protein Binding Substance K Receptor Activity
	Biological Process	Negative Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Regulation Of Blood Pressure Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Sensory Perception Of Pain Positive Regulation Of Flagellated Sperm Motility Negative Regulation Of Sensory Perception Of Pain Positive Regulation Of Sensory Perception Of Pain	Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Positive Regulation Of Acetylcholine Secretion, Neurotransmission Intestine Smooth Muscle Contraction Negative Regulation Of Luteinizing Hormone Secretion Operant Conditioning Positive Regulation Of Vascular Permeability Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Smooth Muscle Contraction Response To Electrical Stimulus Prolactin Secretion Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility
Pathways			Tachykinin receptors bind tachykinins G alpha (q) signalling events
Drugs			Saredutant
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		3 interacting genes: TACR1 TACR2 TACR3	5 interacting genes: GPRASP1 MTDH TAC1 TAC3 TAC4
Entrez ID		255061	6865
HPRD ID		09701	01207
Ensembl ID		ENSG00000176358	ENSG00000075073
Uniprot IDs		Q86UU9	P21452
PDB IDs		2MOC	7XWO
Enriched GO Terms of Interacting Partners?		Tachykinin Receptor Activity Positive Regulation Of Uterine Smooth Muscle Contraction Tachykinin Receptor Signaling Pathway Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Positive Regulation Of Smooth Muscle Contraction Regulation Of Cilium Movement Positive Regulation Of Muscle Contraction Sperm Midpiece Regulation Of Microtubule-based Movement Regulation Of Smooth Muscle Contraction Positive Regulation Of Reproductive Process Operant Conditioning Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Muscle Contraction Sperm Head Regulation Of Reproductive Process Positive Regulation Of Vascular Permeability Regulation Of Muscle System Process Regulation Of Microtubule-based Process Positive Regulation Of Blood Pressure G Protein-coupled Receptor Activity Response To Electrical Stimulus Regulation Of Vascular Permeability Smooth Muscle Contraction Regulation Of System Process Positive Regulation Of Cell Motility Positive Regulation Of Locomotion G Protein-coupled Receptor Signaling Pathway Response To Estradiol Sperm Flagellum Substance K Receptor Activity Substance P Receptor Activity Regulation Of Cell Motility Positive Regulation Of Synaptic Transmission Regulation Of Locomotion Learning Regulation Of Blood Pressure Angiotensin-mediated Drinking Behavior Muscle Contraction Prolactin Secretion Negative Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Smooth Muscle Contraction Involved In Micturition Regulation Of Hormone Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Muscle System Process Intestine Smooth Muscle Contraction	Substance K Receptor Binding Tachykinin Receptor Signaling Pathway Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Substance P Receptor Binding Neuromedin K Receptor Binding Regulation Of Cilium Movement Regulation Of Microtubule-based Movement Positive Regulation Of Sensory Perception Of Pain Positive Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Sensory Perception Of Pain Regulation Of Blood Pressure Detection Of Temperature Stimulus Involved In Sensory Perception Regulation Of Reproductive Process Negative Regulation Of Systemic Arterial Blood Pressure Detection Of Temperature Stimulus Regulation Of Microtubule-based Process Negative Regulation Of Blood Pressure Neuropeptide Signaling Pathway Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Protein Location In Plasma Membrane Regulation Of Nervous System Process Positive Regulation Of Cell Motility G Protein-coupled Receptor Catabolic Process Bicellular Tight Junction Positive Regulation Of Locomotion Detection Of Abiotic Stimulus Receptor Ligand Activity Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Corticosterone Secretion Detection Of Stimulus Involved In Sensory Perception Negative Regulation Of Sensory Perception Of Pain Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Temperature Stimulus Insemination Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential G Protein-coupled Receptor Signaling Pathway Cellular Response To Magnesium Ion Regulation Of Corticosterone Secretion Intercellular Canaliculus Channel Activator Activity Regulation Of Membrane Depolarization During Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Synaptic Transmission, Cholinergic Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Spectrin-associated Cytoskeleton Negative Regulation Of Voltage-gated Potassium Channel Activity Regulation Of Delayed Rectifier Potassium Channel Activity
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