TACR3 and TAC3

Number of citations of the paper that reports this interaction (PubMedID 8990205)
29

Data Source:
HPRD (in vitro, in vivo)

		TACR3	TAC3
Description		tachykinin receptor 3	tachykinin precursor 3
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Membrane Neuronal Cell Body Membrane Sperm Midpiece	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Tachykinin Receptor Activity Protein Binding	Signaling Receptor Binding Protein Binding Neuromedin K Receptor Binding Substance K Receptor Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Positive Regulation Of Heart Rate Response To Estradiol Regulation Of Dopamine Metabolic Process Response To Cocaine Positive Regulation Of Blood Pressure Regulation Of Feeding Behavior Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility	Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Positive Regulation Of Blood Pressure Positive Regulation Of Flagellated Sperm Motility
Pathways		Tachykinin receptors bind tachykinins G alpha (q) signalling events	Tachykinin receptors bind tachykinins G alpha (q) signalling events
Drugs		Osanetant Talnetant Pavinetant	Copper
Diseases		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)	Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Chronotype ( 30696823) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Menarche (age at onset) ( 25231870 27182965) Rosacea symptom severity ( 29771307) Spontaneous preterm birth without premature rupture of membranes ( 31194736)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Menopause (age at onset) ( 26414677) Red cell distribution width ( 28957414) Schizophrenia ( 25056061)
Interacting Genes		4 interacting genes: GPRASP1 TAC1 TAC3 TAC4	12 interacting genes: CCDC90B ELP1 FEZ1 GPRASP1 PRB1 PRH1 PTN TACR1 TACR2 TACR3 UBC UBR1
Entrez ID		6870	6866
HPRD ID		01209	08877
Ensembl ID		ENSG00000169836	ENSG00000166863
Uniprot IDs		P29371	Q9UHF0
PDB IDs		8JBF 8JBG 8JBH	1P9F 8JBG
Enriched GO Terms of Interacting Partners?		Substance K Receptor Binding Tachykinin Receptor Signaling Pathway Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Substance P Receptor Binding Neuromedin K Receptor Binding Regulation Of Cilium Movement Regulation Of Microtubule-based Movement Positive Regulation Of Sensory Perception Of Pain Positive Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Blood Pressure Regulation Of Sensory Perception Of Pain Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Negative Regulation Of Systemic Arterial Blood Pressure Detection Of Temperature Stimulus Regulation Of Microtubule-based Process Negative Regulation Of Blood Pressure Neuropeptide Signaling Pathway Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Nervous System Process Detection Of Abiotic Stimulus Receptor Ligand Activity G Protein-coupled Receptor Catabolic Process Detection Of Stimulus Involved In Sensory Perception Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Temperature Stimulus G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Corticosterone Secretion Negative Regulation Of Sensory Perception Of Pain Insemination Regulation Of Corticosterone Secretion Regulation Of Cell Motility Positive Regulation Of Synaptic Transmission, Cholinergic Detection Of Stimulus Regulation Of Locomotion Positive Regulation Of Action Potential Antifungal Humoral Response Negative Regulation Of Heart Rate Response To Yeast Positive Regulation Of Synaptic Transmission, GABAergic Response To Pain Extracellular Space Receptor Catabolic Process Negative Regulation Of Nervous System Process Negative Regulation Of Heart Contraction Neuronal Dense Core Vesicle	Tachykinin Receptor Activity Positive Regulation Of Uterine Smooth Muscle Contraction Tachykinin Receptor Signaling Pathway Regulation Of Uterine Smooth Muscle Contraction Regulation Of Microtubule-based Movement Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Positive Regulation Of Smooth Muscle Contraction Regulation Of Cilium Movement Operant Conditioning Positive Regulation Of Muscle Contraction Sperm Midpiece Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Smooth Muscle Contraction Positive Regulation Of Reproductive Process Regulation Of Microtubule-based Process Sperm Head Positive Regulation Of Vascular Permeability Response To Auditory Stimulus Learning Regulation Of Muscle Contraction Positive Regulation Of Blood Pressure Regulation Of Reproductive Process Response To Electrical Stimulus Regulation Of Vascular Permeability Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Ossification Smooth Muscle Contraction Substance K Receptor Activity Regulation Of Muscle System Process Substance P Receptor Activity Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Learning Or Memory Cognition Dendrite Regeneration Angiotensin-mediated Drinking Behavior G Protein-coupled Receptor Catabolic Process Ossification Involved In Bone Remodeling G Protein-coupled Receptor Activity Prolactin Secretion Negative Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Smooth Muscle Contraction Involved In Micturition TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Regulation Of Acetylcholine Secretion, Neurotransmission Intestine Smooth Muscle Contraction Response To Ozone Response To Estradiol
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