TAC4 and TACR3

Number of citations of the paper that reports this interaction (PubMedID 11786503)
32

Data Source:
HPRD (in vivo, in vitro)

		TAC4	TACR3
Description		tachykinin precursor 4	tachykinin receptor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Membrane Dendrite Membrane Neuronal Cell Body Membrane Sperm Midpiece
	Molecular Function	Substance P Receptor Binding Substance K Receptor Binding Receptor Ligand Activity	G Protein-coupled Receptor Activity Tachykinin Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Regulation Of Blood Pressure Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Sensory Perception Of Pain Positive Regulation Of Flagellated Sperm Motility Negative Regulation Of Sensory Perception Of Pain Positive Regulation Of Sensory Perception Of Pain	Signal Transduction G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Positive Regulation Of Heart Rate Response To Estradiol Regulation Of Dopamine Metabolic Process Response To Cocaine Positive Regulation Of Blood Pressure Regulation Of Feeding Behavior Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility
Pathways			Tachykinin receptors bind tachykinins G alpha (q) signalling events
Drugs			Osanetant Talnetant Pavinetant
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Serum alkaline phosphatase levels ( 33547301)	Chronotype ( 30696823) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Menarche (age at onset) ( 25231870 27182965) Rosacea symptom severity ( 29771307) Spontaneous preterm birth without premature rupture of membranes ( 31194736)
Interacting Genes		3 interacting genes: TACR1 TACR2 TACR3	4 interacting genes: GPRASP1 TAC1 TAC3 TAC4
Entrez ID		255061	6870
HPRD ID		09701	01209
Ensembl ID		ENSG00000176358	ENSG00000169836
Uniprot IDs		Q86UU9	P29371
PDB IDs		2MOC	8JBF 8JBG 8JBH
Enriched GO Terms of Interacting Partners?		Tachykinin Receptor Activity Positive Regulation Of Uterine Smooth Muscle Contraction Tachykinin Receptor Signaling Pathway Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Positive Regulation Of Smooth Muscle Contraction Regulation Of Cilium Movement Positive Regulation Of Muscle Contraction Sperm Midpiece Regulation Of Microtubule-based Movement Regulation Of Smooth Muscle Contraction Positive Regulation Of Reproductive Process Operant Conditioning Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Muscle Contraction Sperm Head Regulation Of Reproductive Process Positive Regulation Of Vascular Permeability Regulation Of Muscle System Process Regulation Of Microtubule-based Process Positive Regulation Of Blood Pressure G Protein-coupled Receptor Activity Response To Electrical Stimulus Regulation Of Vascular Permeability Smooth Muscle Contraction Regulation Of System Process Positive Regulation Of Cell Motility Positive Regulation Of Locomotion G Protein-coupled Receptor Signaling Pathway Response To Estradiol Sperm Flagellum Substance K Receptor Activity Substance P Receptor Activity Regulation Of Cell Motility Positive Regulation Of Synaptic Transmission Regulation Of Locomotion Learning Regulation Of Blood Pressure Angiotensin-mediated Drinking Behavior Muscle Contraction Prolactin Secretion Negative Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Smooth Muscle Contraction Involved In Micturition Regulation Of Hormone Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Muscle System Process Intestine Smooth Muscle Contraction	Substance K Receptor Binding Tachykinin Receptor Signaling Pathway Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Substance P Receptor Binding Neuromedin K Receptor Binding Regulation Of Cilium Movement Regulation Of Microtubule-based Movement Positive Regulation Of Sensory Perception Of Pain Positive Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Blood Pressure Regulation Of Sensory Perception Of Pain Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Negative Regulation Of Systemic Arterial Blood Pressure Detection Of Temperature Stimulus Regulation Of Microtubule-based Process Negative Regulation Of Blood Pressure Neuropeptide Signaling Pathway Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Nervous System Process Detection Of Abiotic Stimulus Receptor Ligand Activity G Protein-coupled Receptor Catabolic Process Detection Of Stimulus Involved In Sensory Perception Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Temperature Stimulus G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Corticosterone Secretion Negative Regulation Of Sensory Perception Of Pain Insemination Regulation Of Corticosterone Secretion Regulation Of Cell Motility Positive Regulation Of Synaptic Transmission, Cholinergic Detection Of Stimulus Regulation Of Locomotion Positive Regulation Of Action Potential Antifungal Humoral Response Negative Regulation Of Heart Rate Response To Yeast Positive Regulation Of Synaptic Transmission, GABAergic Response To Pain Extracellular Space Receptor Catabolic Process Negative Regulation Of Nervous System Process Negative Regulation Of Heart Contraction Neuronal Dense Core Vesicle
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