TAC4 and TACR1

Number of citations of the paper that reports this interaction (PMID 11786503)
7

Data Source:
HPRD (in vitro, in vivo)

		TAC4	TACR1
Gene Name		tachykinin 4 (hemokinin)	tachykinin receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Dendrite Cell Body
	Molecular Function	Receptor Binding	Tachykinin Receptor Activity Protein Binding Substance P Receptor Activity
	Biological Process	Tachykinin Receptor Signaling Pathway Regulation Of Blood Pressure Positive Regulation Of Saliva Secretion	Aggressive Behavior Acute Inflammatory Response Positive Regulation Of Leukocyte Migration Angiotensin-mediated Drinking Behavior Inflammatory Response Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Long-term Memory Associative Learning Response To Heat Detection Of Abiotic Stimulus Response To Ozone Positive Regulation Of Epithelial Cell Migration Response To Auditory Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Progesterone Response To Nicotine Operant Conditioning Positive Regulation Of Renal Sodium Excretion Sperm Ejaculation Eating Behavior Positive Regulation Of Vascular Permeability Response To Morphine Response To Ethanol Positive Regulation Of Action Potential Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Vasoconstriction Positive Regulation Of Saliva Secretion Positive Regulation Of Hormone Secretion Behavioral Response To Pain Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Stress Fiber Assembly Response To Electrical Stimulus Smooth Muscle Contraction Involved In Micturition Positive Regulation Of Uterine Smooth Muscle Contraction
Pathways			G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Tachykinin receptors bind tachykinins Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Aprepitant Ketamine Vapreotide
Diseases
GWAS			Brain connectivity ( 23471985)
Protein-Protein Interactions		4 interactors: TAC1 TACR1 TACR2 TACR3	5 interactors: GPRASP1 GRK5 TAC1 TAC3 TAC4
Entrez ID		255061	6869
HPRD ID		09701	01208
Ensembl ID		ENSG00000176358	ENSG00000115353
Uniprot IDs		Q86UU9	P25103
PDB IDs			2KS9 2KSA 2KSB
Enriched GO Terms of Interacting Partners?		Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Response To Morphine Blood Circulation Regulation Of Smooth Muscle Contraction Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Saliva Secretion Response To Ammonium Ion Operant Conditioning Regulation Of Synaptic Transmission, Cholinergic Regulation Of Saliva Secretion Synaptic Transmission Positive Regulation Of Synaptic Transmission Positive Regulation Of Action Potential Learning Response To Alkaloid Regulation Of Muscle Contraction Positive Regulation Of Digestive System Process Positive Regulation Of Vascular Permeability Positive Regulation Of Renal Sodium Excretion Regulation Of Blood Pressure Positive Regulation Of Synaptic Transmission, GABAergic Cell-cell Signaling Insemination Regulation Of Renal Sodium Excretion Response To Abiotic Stimulus Copulation Regulation Of Hormone Secretion Learning Or Memory Regulation Of Excretion G-protein Coupled Receptor Signaling Pathway Cognition Regulation Of Synaptic Transmission Regulation Of Vascular Permeability Positive Regulation Of Secretion Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Blood Pressure Response To Pain Response To Electrical Stimulus Positive Regulation Of Stress Fiber Assembly Long-term Memory Excretion Positive Regulation Of Actin Filament Bundle Assembly Single-organism Behavior Mating Smooth Muscle Contraction Regulation Of Stress Fiber Assembly Regulation Of Heart Rate	Tachykinin Receptor Signaling Pathway Positive Regulation Of Saliva Secretion Regulation Of Saliva Secretion Positive Regulation Of Digestive System Process G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Catabolic Process Positive Regulation Of Corticosterone Secretion Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Blood Pressure Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Corticosterone Secretion Regulation Of Synaptic Transmission, Cholinergic Cell Surface Receptor Signaling Pathway Blood Circulation Positive Regulation Of Secretion Positive Regulation Of Action Potential Negative Regulation Of Heart Rate Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Synaptic Transmission, GABAergic Insemination Receptor Catabolic Process Regulation Of Renal Sodium Excretion Copulation Negative Regulation Of Heart Contraction Regulation Of Excretion Positive Regulation Of Acute Inflammatory Response Endosome To Lysosome Transport Regulation Of Secretion Regulation Of Synaptic Transmission, GABAergic Response To Pain Response To Morphine Positive Regulation Of Transport Positive Regulation Of Stress Fiber Assembly Lysosomal Transport Long-term Memory Signal Transduction Positive Regulation Of Actin Filament Bundle Assembly Mating Positive Regulation Of Lipid Transport Signaling Regulation Of Stress Fiber Assembly Termination Of G-protein Coupled Receptor Signaling Pathway Cell Communication Termination Of Signal Transduction Regulation Of Acute Inflammatory Response Regulation Of Heart Rate
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