RAB1A and PSMD7

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		RAB1A	PSMD7
Gene Name		RAB1A, member RAS oncogene family	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Early Endosome Endoplasmic Reticulum Membrane Cytosol Melanosome Extracellular Vesicular Exosome	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Protein Binding Protein Homodimerization Activity
	Biological Process	Autophagic Vacuole Assembly Mitotic Cell Cycle Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Endocytosis Autophagy Golgi Organization Vesicle-mediated Transport Cell Migration Virion Assembly Growth Hormone Secretion Melanosome Transport Rab Protein Signal Transduction Substrate Adhesion-dependent Cell Spreading Cilium Assembly Defense Response To Bacterium Vesicle Transport Along Microtubule Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Glycoprotein Metabolic Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Cell Cycle, Mitotic M Phase	Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: ADCK1 CAPNS1 CDKN1A CHM CHML CREB1 FSCN1 GOLGA2 GOLGA5 GORASP2 HIVEP1 MAPRE3 MICAL1 MICALL1 OCRL PSMD7 RABAC1 RABEP1 RABGGTA RABGGTB RABIF RFK RUSC2 SLC16A8 SYT5 TBC1D17 USO1 ZNF593	7 interactors: ATXN3 PSMC1 PSMD14 RAB1A SLC2A4 TRAF6 VIM
Entrez ID		5861	5713
HPRD ID		01538	01147
Ensembl ID		ENSG00000138069	ENSG00000103035
Uniprot IDs		B7Z8M7 P62820 Q5U0I6	P51665
PDB IDs		2FOL 2WWX 3L0I 3SFV 3TKL 4FMB 4FMC 4FMD 4FME 4IRU 4JVS	2O95 2O96
Enriched GO Terms of Interacting Partners?		Protein Geranylgeranylation Protein Prenylation Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Mitotic Cell Cycle Regulation Of GTPase Activity Membrane Fusion Positive Regulation Of Metabolic Process Protein Transport Establishment Of Protein Localization Visual Perception Sensory Perception Of Light Stimulus Slow Endocytic Recycling Riboflavin Biosynthetic Process FMN Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Membrane Organization Positive Regulation Of Microtubule Plus-end Binding Golgi Vesicle Docking Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Cell Cycle Positive Regulation Of Cell Cycle Arrest Cellular Process Positive Regulation Of NAD(P)H Oxidase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Apoptotic Process Protein Localization Vesicle-mediated Transport Programmed Cell Death Signal Transduction In Response To DNA Damage Establishment Of Localization In Cell Mitotic DNA Damage Checkpoint Cell Death Death Intestinal Epithelial Cell Maturation Riboflavin Metabolic Process Regulation Of Cell Cycle Arrest Intracellular Transport Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint	Cellular Response To Stress Positive Regulation Of Protein Ubiquitination Viral Process Protein K63-linked Deubiquitination Protein Polyubiquitination Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Peptide Antigen Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Stress Antigen Processing And Presentation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Apoptotic Process Programmed Cell Death Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cell Death Death Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To Stimulus Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity Positive Regulation Of Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Amylopectin Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Modification-dependent Protein Catabolic Process Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Negative Regulation Of Protein Ubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Protein Deubiquitination
Tagcloud ?		added become broadly characterises eevs enveloped exploits facilitating golgi growing gtpase highlighting ievs immunofluorescence imvs list maintenance mature numerous optimal proviral refined replication require stranded vaccinia vacv virions wrapping
Tagcloud (Difference) ?		added become broadly characterises eevs enveloped exploits facilitating golgi growing gtpase highlighting ievs immunofluorescence imvs list maintenance mature numerous optimal proviral refined replication require stranded vaccinia vacv virions wrapping
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