RAB1A and RABGGTA

Number of citations of the paper that reports this interaction (PubMedID 7991565)
23

Data Source:
HPRD (in vitro)

		RAB1A	RABGGTA
Description		RAB1A, member RAS oncogene family	Rab geranylgeranyltransferase subunit alpha
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Endomembrane System Membrane Transport Vesicle Membrane Melanosome Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Cadherin Binding Metal Ion Binding	Prenyltransferase Activity Protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Protein Prenyltransferase Activity Transferase Activity Small GTPase Binding
	Biological Process	Autophagosome Assembly Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endocytosis Autophagy Golgi Organization Protein Transport Vesicle-mediated Transport Cell Migration Virion Assembly Growth Hormone Secretion Melanosome Transport Positive Regulation Of Interleukin-8 Production Substrate Adhesion-dependent Cell Spreading Defense Response To Bacterium Vesicle Transport Along Microtubule Cilium Assembly COPII-coated Vesicle Cargo Loading Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Glycoprotein Metabolic Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Visual Perception Protein Geranylgeranylation Protein Modification Process
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation
Drugs			N-Formylmethionine Farnesyl diphosphate Geranylgeranyl diphosphate
Diseases
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Triglyceride levels ( 32154731)
Interacting Genes		32 interacting genes: ADCK1 CAPNS1 CDKN1A CHML CREB1 CSNK1D FNDC3B FSCN1 GOLGA2 GOLGA5 GORASP2 HIVEP1 MAPRE3 MICAL1 MICALL1 MTOR OCRL PLK1 PSMD7 RABAC1 RABEP1 RABGGTA RABGGTB RFK RUSC2 SLC16A8 SNCA SSX2IP SYT5 TBC1D17 USO1 ZNF593	2 interacting genes: BMPR2 RAB1A
Entrez ID		5861	5875
HPRD ID		01538	03547
Ensembl ID		ENSG00000138069	ENSG00000100949
Uniprot IDs		B7Z8M7 P62820 Q5U0I6	Q92696
PDB IDs		2FOL 2WWX 3L0I 3SFV 3TKL 4FMB 4FMC 4FMD 4FME 4IRU 4JVS 7EQ2 9MHF 9MHG 9MHH
Enriched GO Terms of Interacting Partners?		Rab-protein Geranylgeranyltransferase Complex Protein Geranylgeranylation Small GTPase Binding Golgi Organization Protein Prenylation Vesicle-mediated Transport Organelle Organization Golgi Vesicle Transport Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Protein Prenyltransferase Activity Cytoplasm Organelle Assembly Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Localization Protein Localization To Cytoskeleton Centrosome Cycle Cis-Golgi Network Establishment Of Localization In Cell Prenyltransferase Activity Protein Destabilization Cytoplasmic Vesicle Protein Localization To Cilium Spindle Organization Cytosol Ciliary Basal Body Cadherin Binding Intracellular Transport Behavioral Response To Cocaine Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Organizing Center Organization Positive Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Vesicle Fusion Establishment Of Protein Localization Cell Projection Assembly Spindle Assembly Protein Serine/threonine Kinase Binding Protein Localization To Organelle GTPase Activator Activity Chemotaxis To Arachidonate Regulation Of Protein-containing Complex Assembly Microtubule Nucleation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cilium Assembly Cellular Component Assembly Protein Localization To Centrosome Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Organelle Assembly	Cadherin Binding Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Chondrocyte Proliferation Regulation Of Lung Blood Pressure Aortic Valve Development Lymphatic Endothelial Cell Differentiation BMP Receptor Activity Pulmonary Valve Development Tricuspid Valve Morphogenesis Venous Blood Vessel Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Activin Receptor Activity, Type II Endochondral Bone Morphogenesis Transforming Growth Factor Beta Receptor Activity Semi-lunar Valve Development Mitral Valve Morphogenesis Growth Hormone Secretion Virion Assembly Maternal Placenta Development Lung Vasculature Development Pharyngeal Arch Artery Morphogenesis Endothelial Cell Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Negative Regulation Of Vasoconstriction Endocardial Cushion Development Regulation Of Axon Extension Involved In Axon Guidance Lymphangiogenesis Retina Vasculature Development In Camera-type Eye Atrial Septum Morphogenesis Establishment Of Endothelial Intestinal Barrier Heart Valve Development BMP Binding Regulation Of Cell Proliferation Involved In Heart Morphogenesis Atrioventricular Valve Morphogenesis Cell Development Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Glycoprotein Metabolic Process Establishment Of Melanosome Localization Melanosome Localization COPII-coated Vesicle Cargo Loading Melanosome Transport Pigment Granule Transport Pigment Granule Localization Outflow Tract Septum Morphogenesis Endothelial Cell Differentiation Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development
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