SURF2 and PLAUR

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SURF2	PLAUR
Gene Name		surfeit 2	plasminogen activator, urokinase receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleus Nucleolus Plasma Membrane	Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome Invadopodium Membrane
	Molecular Function	Molecular_function	Receptor Activity Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity
	Biological Process	Biological_process	C-terminal Protein Lipidation Movement Of Cell Or Subcellular Component Chemotaxis Signal Transduction Blood Coagulation Attachment Of GPI Anchor To Protein Regulation Of Proteolysis Urokinase Plasminogen Activator Signaling Pathway Fibrinolysis Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Post-translational protein modification Attachment of GPI anchor to uPAR Dissolution of Fibrin Clot Post-translational modification: synthesis of GPI-anchored proteins
Drugs			Alteplase Urokinase Reteplase Anistreplase Tenecteplase
Diseases
GWAS		Activated partial thromboplastin time ( 22703881)
Protein-Protein Interactions		7 interactors: APP B4GALT3 NPTN PLAUR PRNP RPL5 ZNF331	20 interactors: EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PFN2 PLAU SRPX2 SURF2 TYK2 VTN
Entrez ID		6835	5329
HPRD ID		15948	01421
Ensembl ID		ENSG00000148291	ENSG00000011422
Uniprot IDs		Q15527	M0R1I2 Q03405
PDB IDs			1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74
Enriched GO Terms of Interacting Partners?		Cellular Copper Ion Homeostasis Copper Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Urokinase Plasminogen Activator Signaling Pathway Cellular Chemical Homeostasis Ion Homeostasis Chemotaxis Synaptic Growth At Neuromuscular Junction Transition Metal Ion Homeostasis Cellular Homeostasis Collateral Sprouting In Absence Of Injury Negative Regulation Of Calcineurin-NFAT Signaling Cascade Collateral Sprouting Axon Midline Choice Point Recognition Post-translational Protein Modification Chemical Homeostasis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Copper Ion Axon Choice Point Recognition Negative Regulation Of Calcium-mediated Signaling Regulation Of Protein Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Learning Or Memory Neuron Remodeling Negative Regulation Of Interleukin-17 Production Regulation Of Protein Phosphorylation Regulation Of Calcineurin-NFAT Signaling Cascade Cognition Cellular Calcium Ion Homeostasis Cellular Protein Metabolic Process Calcium Ion Homeostasis Attachment Of GPI Anchor To Protein Negative Regulation Of Activated T Cell Proliferation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Locomotion Regulation Of Phosphorylation Axon Guidance Negative Regulation Of Interleukin-2 Production Homeostatic Process Negative Regulation Of T Cell Receptor Signaling Pathway Response To Oxidative Stress Blood Coagulation Hemostasis Response To Copper Ion Suckling Behavior Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component	Cell Motility Cell Migration Locomotion Peptidyl-tyrosine Autophosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune Response Regulation Of Cell Proliferation Regulation Of Collagen Catabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Immune System Process Regulation Of Cell Migration Regulation Of Smooth Muscle Cell Migration Defense Response Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Motility Developmental Process Endocytosis Regulation Of Apoptotic Process Negative Regulation Of Blood Coagulation Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Negative Regulation Of Coagulation Regulation Of Cell Death Blood Coagulation Hemostasis Protein Autophosphorylation Negative Regulation Of Wound Healing Cell Adhesion Leukocyte Migration Innate Immune Response Regulation Of Innate Immune Response Cell Adhesion Mediated By Integrin Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Blood Coagulation Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Vesicle-mediated Transport Activated T Cell Proliferation Integrin-mediated Signaling Pathway Regulation Of Wound Healing Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cellular Process Regulation Of Defense Response To Virus By Virus Positive Regulation Of Cell Adhesion Extracellular Matrix Organization
Tagcloud ?			alters ap attributed cascade chemo chief designating erk1 fos fra govern isoform mapk microrna mir mirna multifaceted next oncogenic serpine1 shortening singular snail thousands transcriptome transcriptomes tumorigenesis utrs zeb1
Tagcloud (Difference) ?			alters ap attributed cascade chemo chief designating erk1 fos fra govern isoform mapk microrna mir mirna multifaceted next oncogenic serpine1 shortening singular snail thousands transcriptome transcriptomes tumorigenesis utrs zeb1
Tagcloud (Intersection) ?