SURF2 and B4GALT3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SURF2	B4GALT3
Gene Name		surfeit 2	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleus Nucleolus Plasma Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Integral Component Of Membrane Golgi Cisterna Membrane Extracellular Vesicular Exosome
	Molecular Function	Molecular_function	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Galactosyltransferase Activity Metal Ion Binding
	Biological Process	Biological_process	Carbohydrate Metabolic Process Pathogenesis Keratan Sulfate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process
Pathways			Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective MGAT2 causes MGAT2-CDG (CDG-2a) N-Glycan antennae elongation Defective CHST14 causes EDS, musculocontractural type N-glycan antennae elongation in the medial/trans-Golgi Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases Keratan sulfate biosynthesis Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective EXT2 causes exostoses 2 Asparagine N-linked glycosylation MPS IV - Morquio syndrome A Defective MPDU1 causes MPDU1-CDG (CDG-1f) Metabolism of carbohydrates Diseases associated with N-glycosylation of proteins MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective SLC26A2 causes chondrodysplasias Transport to the Golgi and subsequent modification Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective PAPSS2 causes SEMD-PA Defective MAN1B1 causes MRT15 MPS IIIA - Sanfilippo syndrome A Defective ALG11 causes ALG11-CDG (CDG-1p) MPS IIIC - Sanfilippo syndrome C Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881)
Protein-Protein Interactions		7 interactors: APP B4GALT3 NPTN PLAUR PRNP RPL5 ZNF331	3 interactors: ARL15 SAT1 SURF2
Entrez ID		6835	8703
HPRD ID		15948	04929
Ensembl ID		ENSG00000148291	ENSG00000158850
Uniprot IDs		Q15527	A8K5Z0 O60512
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Copper Ion Homeostasis Copper Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Urokinase Plasminogen Activator Signaling Pathway Cellular Chemical Homeostasis Ion Homeostasis Chemotaxis Synaptic Growth At Neuromuscular Junction Transition Metal Ion Homeostasis Cellular Homeostasis Collateral Sprouting In Absence Of Injury Negative Regulation Of Calcineurin-NFAT Signaling Cascade Collateral Sprouting Axon Midline Choice Point Recognition Post-translational Protein Modification Chemical Homeostasis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Copper Ion Axon Choice Point Recognition Negative Regulation Of Calcium-mediated Signaling Regulation Of Protein Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Learning Or Memory Neuron Remodeling Negative Regulation Of Interleukin-17 Production Regulation Of Protein Phosphorylation Regulation Of Calcineurin-NFAT Signaling Cascade Cognition Cellular Calcium Ion Homeostasis Cellular Protein Metabolic Process Calcium Ion Homeostasis Attachment Of GPI Anchor To Protein Negative Regulation Of Activated T Cell Proliferation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Locomotion Regulation Of Phosphorylation Axon Guidance Negative Regulation Of Interleukin-2 Production Homeostatic Process Negative Regulation Of T Cell Receptor Signaling Pathway Response To Oxidative Stress Blood Coagulation Hemostasis Response To Copper Ion Suckling Behavior Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component	Spermidine Acetylation Putrescine Catabolic Process Oxalate Transport 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Polyamine Catabolic Process Neurotransmitter Uptake 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Polyamine Biosynthetic Process Amine Biosynthetic Process Polyamine Metabolic Process Sulfate Transmembrane Transport Sulfate Transport Neutral Amino Acid Transport
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