SURF1 and PTGES3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SURF1	PTGES3
Gene Name		surfeit 1	prostaglandin E synthase 3 (cytosolic)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Respiratory Chain Integral Component Of Membrane	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding	Telomerase Activity Protein Binding Prostaglandin-E Synthase Activity Unfolded Protein Binding
	Biological Process	Oxidative Phosphorylation ATP Biosynthetic Process Respiratory Chain Complex IV Assembly Aerobic Respiration Oxidation-reduction Process Hydrogen Ion Transmembrane Transport	Telomere Maintenance Prostaglandin Biosynthetic Process RNA-dependent DNA Replication Signal Transduction Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Cellular Response To Heat Small Molecule Metabolic Process Chaperone Cofactor-dependent Protein Refolding Regulation Of Cellular Response To Heat
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport Orphan transporters	Arachidonic acid metabolism HSF1 activation HSF1-dependent transactivation Metabolism of lipids and lipoproteins Attenuation phase Cellular response to heat stress Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs
Diseases
GWAS			Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		1 interactors: PTGES3	25 interactors: AHR AIP ARNT CASP3 CASP7 CAV3 CD2AP COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSPA1A NR3C1 NR3C2 STIP1 SURF1 TERT THRA
Entrez ID		6834	10728
HPRD ID		01711	06138
Ensembl ID		ENSG00000148290	ENSG00000110958
Uniprot IDs		E5KRX5 Q15526	Q15185
PDB IDs			1EJF 1LG0
Enriched GO Terms of Interacting Partners?		Chaperone Cofactor-dependent Protein Refolding Cyclooxygenase Pathway Protein Refolding RNA-dependent DNA Replication Prostaglandin Biosynthetic Process Prostaglandin Metabolic Process Regulation Of Cellular Response To Heat Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Chaperone-mediated Protein Folding Arachidonic Acid Metabolic Process Cellular Response To Heat Telomere Maintenance Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Response To Heat DNA Biosynthetic Process Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Response To Temperature Stimulus DNA Replication Protein Folding Fatty Acid Metabolic Process	Regulation Of Cellular Response To Heat Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Heat Regulation Of Apoptotic Process Regulation Of Cell Proliferation Protein Refolding Response To Temperature Stimulus Regulation Of Cellular Component Organization Regulation Of Cell Death Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Response To Heat Regulation Of Nitric-oxide Synthase Activity Response To Unfolded Protein Hormone-mediated Signaling Pathway Regulation Of Protein Complex Assembly Transcription From RNA Polymerase II Promoter Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Metabolic Process Regulation Of Immune System Process Signal Transduction Regulation Of Signal Transduction Cellular Response To Organic Cyclic Compound Negative Regulation Of Inclusion Body Assembly Response To Stress Gene Expression Cellular Response To Organic Substance Positive Regulation Of Myeloid Cell Differentiation Regulation Of Oxidoreductase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C DNA-templated Transcription, Initiation Response To Abiotic Stimulus Positive Regulation Of Microtubule Polymerization Signaling Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Communication Organelle Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Inclusion Body Assembly Positive Regulation Of Protein Metabolic Process Protein Folding Nucleobase-containing Compound Metabolic Process
Tagcloud ?		appearance assembly bn destined drive fission imf impairments import iv ko mitochondria mitochondrial mitophagy mthsp60 mthsp70 page punctate reductions reliance respiration ss subfraction suspect tim23 tom20 ultra unaffected unchanged	12q13 15q25 15q26 3p22 50k beadchip centric cornell customized decile ecg heritability humancvd illumina lvh lyon nmb prognostically qrs rs2290893 rs2292462 rs4966014 rs6797133 scn5a sokolow sum trait typed voltage
Tagcloud (Difference) ?		appearance assembly bn destined drive fission imf impairments import iv ko mitochondria mitochondrial mitophagy mthsp60 mthsp70 page punctate reductions reliance respiration ss subfraction suspect tim23 tom20 ultra unaffected unchanged	12q13 15q25 15q26 3p22 50k beadchip centric cornell customized decile ecg heritability humancvd illumina lvh lyon nmb prognostically qrs rs2290893 rs2292462 rs4966014 rs6797133 scn5a sokolow sum trait typed voltage
Tagcloud (Intersection) ?