SURF1 and PTGES3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SURF1	PTGES3
Description		SURF1 cytochrome c oxidase assembly factor	prostaglandin E synthase 3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytoplasm Cytosol Protein-containing Complex Protein Folding Chaperone Complex
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding	Telomerase Activity Protein Binding Isomerase Activity Prostaglandin-E Synthase Activity Unfolded Protein Binding Protein-folding Chaperone Binding Hsp90 Protein Binding DNA Polymerase Binding
	Biological Process	Respiratory Chain Complex IV Assembly Aerobic Respiration Mitochondrial Cytochrome C Oxidase Assembly Proton Transmembrane Transport	Telomere Maintenance Prostaglandin Biosynthetic Process Protein Folding Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Telomere Maintenance Via Telomerase Signal Transduction Positive Regulation Of Telomere Maintenance Via Telomerase Prostanoid Biosynthetic Process Protein Stabilization Chaperone-mediated Protein Complex Assembly Telomerase Holoenzyme Complex Assembly
Pathways		Complex IV assembly	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSF1 activation Attenuation phase Aryl hydrocarbon receptor signalling ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS
Drugs			Acetaminophen Grn163l Copper
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Heart failure ( 31919418) Malaria ( 31844061)	Alanine aminotransferase levels ( 33547301) Asthma ( 31619474) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean platelet volume ( 22139419) Platelet count ( 22139419) Reticulocyte count ( 32888494)
Interacting Genes		1 interacting genes: PTGES3	30 interacting genes: AHR AHSA1 AIP ARNT CASP3 CASP7 CAV3 CD2AP CDC37 COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSPA1A HSPB1 MAPT NR3C1 NR3C2 SIM2 STIP1 SURF1 TERT THRA
Entrez ID		6834	10728
HPRD ID		01711	06138
Ensembl ID		ENSG00000148290	ENSG00000110958
Uniprot IDs		A0A087WYS9 E5KRX5 Q15526	A0A087WYT3 B3KUY2 Q15185
PDB IDs			1EJF 7KRJ 7L7I 7L7J
Enriched GO Terms of Interacting Partners?		Telomerase Holoenzyme Complex Assembly Regulation Of Telomere Maintenance Via Telomerase Chaperone-mediated Protein Complex Assembly Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomerase Telomerase Activity Prostanoid Metabolic Process Telomere Maintenance Via Telomerase Prostaglandin-E Synthase Activity Positive Regulation Of DNA Biosynthetic Process Telomerase Holoenzyme Complex Protein Folding Chaperone Complex Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Hsp90 Protein Binding DNA Polymerase Binding Prostaglandin Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Protein-folding Chaperone Binding DNA Biosynthetic Process Unsaturated Fatty Acid Metabolic Process Telomere Maintenance Icosanoid Metabolic Process Positive Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Unfolded Protein Binding Fatty Acid Biosynthetic Process Telomere Organization Isomerase Activity Chromosome, Telomeric Region Protein Folding Protein-RNA Complex Assembly Protein Stabilization Regulation Of Chromosome Organization Carboxylic Acid Biosynthetic Process Positive Regulation Of DNA Metabolic Process Fatty Acid Metabolic Process Chromosome Organization Regulation Of Protein Stability	Hsp90 Protein Binding Nuclear Receptor Activity TBP-class Protein Binding Unfolded Protein Binding Response To Temperature Stimulus Response To Heat Regulation Of Gene Expression Cellular Response To Heat Regulation Of Macromolecule Biosynthetic Process Response To Lipid Protein Folding Chaperone Regulation Of Macromolecule Metabolic Process Aryl Hydrocarbon Receptor Complex Regulation Of Apoptotic Process Protein Folding Chaperone Complex Cytoplasm Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein Polymerization Response To Unfolded Protein Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Intracellular Signal Transduction Regulation Of Metabolic Process Cytosol Response To Stress Regulation Of Protein-containing Complex Assembly Estrogen Response Element Binding Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lipid Protein-folding Chaperone Binding Negative Regulation Of Inclusion Body Assembly Protein Folding Negative Regulation Of Biosynthetic Process Animal Organ Development Regulation Of Cellular Response To Heat Intracellular Receptor Signaling Pathway Nuclear Aryl Hydrocarbon Receptor Complex Neurofibrillary Tangle Assembly Protein-containing Complex Regulation Of Neuron Apoptotic Process Regulation Of Microtubule Polymerization Regulation Of Inclusion Body Assembly Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Hormone Positive Regulation Of Metabolic Process Response To Hypoxia Sequence-specific DNA Binding Cellular Response To Oxygen-containing Compound DNA-binding Transcription Factor Activity
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