SURF1

Description		SURF1 cytochrome c oxidase assembly factor
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding
	Biological Process	Respiratory Chain Complex IV Assembly Aerobic Respiration Mitochondrial Cytochrome C Oxidase Assembly Proton Transmembrane Transport
Pathways		Complex IV assembly
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Heart failure ( 31919418) Malaria ( 31844061)
Interacting Genes		1 interacting genes: PTGES3
Entrez ID		6834
HPRD ID		01711
Ensembl ID		ENSG00000148290
Uniprot IDs		A0A087WYS9 E5KRX5 Q15526
PDB IDs
Enriched GO Terms of Interacting Partners?		Telomerase Holoenzyme Complex Assembly Regulation Of Telomere Maintenance Via Telomerase Chaperone-mediated Protein Complex Assembly Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomerase Telomerase Activity Prostanoid Metabolic Process Telomere Maintenance Via Telomerase Prostaglandin-E Synthase Activity Positive Regulation Of DNA Biosynthetic Process Telomerase Holoenzyme Complex Protein Folding Chaperone Complex Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Hsp90 Protein Binding DNA Polymerase Binding Prostaglandin Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Protein-folding Chaperone Binding DNA Biosynthetic Process Unsaturated Fatty Acid Metabolic Process Telomere Maintenance Icosanoid Metabolic Process Positive Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Unfolded Protein Binding Fatty Acid Biosynthetic Process Telomere Organization Isomerase Activity Chromosome, Telomeric Region Protein Folding Protein-RNA Complex Assembly Protein Stabilization Regulation Of Chromosome Organization Carboxylic Acid Biosynthetic Process Positive Regulation Of DNA Metabolic Process Fatty Acid Metabolic Process Chromosome Organization Regulation Of Protein Stability
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