KCNJ8 and EMD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNJ8	EMD
Description		potassium inwardly rectifying channel subfamily J member 8	emerin
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Inward Rectifying Potassium Channel Membrane Myofibril Potassium Ion-transporting ATPase Complex Protein-containing Complex Monoatomic Ion Channel Complex Sarcolemma Presynaptic Active Zone Membrane Presynapse Glutamatergic Synapse	Nucleus Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Spindle Cytosol Microtubule Membrane Spindle Pole Centrosome Nuclear Membrane Cortical Endoplasmic Reticulum TMEM240-body
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity Sulfonylurea Receptor Binding ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Actin Binding Protein Binding Cadherin Binding Beta-tubulin Binding
	Biological Process	Action Potential Blood Vessel Development Response To Hypoxia Microglial Cell Activation Kidney Development Vasculature Development Regulation Of Heart Rate Adaptive Immune Response Response To Ischemia Heart Morphogenesis Ventricular Cardiac Muscle Tissue Development Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Response To Stress Inflammatory Response Heart Development Regulation Of Blood Pressure Cell Population Proliferation Determination Of Adult Lifespan Protein Secretion Response To Xenobiotic Stimulus Gene Expression Fatty Acid Transport Transmission Of Nerve Impulse Establishment Of Cell Polarity Response To Lipopolysaccharide Response To Insulin Response To ATP Response To Cytokine Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress P38MAPK Cascade Vasodilation Response To Exogenous DsRNA NLRP3 Inflammasome Complex Assembly Fat Cell Differentiation Fibroblast Proliferation Nervous System Process Neuromuscular Process Synaptic Assembly At Neuromuscular Junction Defense Response To Virus Cardiac Pacemaker Cell Differentiation Atrioventricular Node Cell Differentiation Coronary Vasculature Development Glutamate Secretion, Neurotransmission CAMKK-AMPK Signaling Cascade Calcium Ion Transmembrane Transport Potassium Ion Transmembrane Transport Circulatory System Development Inorganic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Presynaptic Membrane Potential Reactive Gliosis Transport Across Blood-brain Barrier Response To Resveratrol Potassium Ion Import Across Plasma Membrane	Muscle Contraction Muscle Organ Development Skeletal Muscle Cell Differentiation Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Fibroblast Proliferation Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus Nuclear Membrane Organization Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid Fibril Formation
Pathways		ATP sensitive Potassium channels	Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerization of the Nuclear Lamina RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Ritodrine Phenformin Levosimendan Glyburide Thiamylal Gliquidone Glisoxepide Yohimbine Butamben
Diseases			Emery-Dreifuss muscular dystrophy
GWAS		Birth weight ( 31043758)	Mean spheric corpuscular volume ( 32888494)
Interacting Genes		7 interacting genes: ABCC8 ABCC9 EMD KCNJ11 KCNJ2 TMEM140 TMEM54	100 interacting genes: ABL1 ABT1 ACTB ACTG2 AEN AKAP8L ANK1 ANKS6 AQP6 AVPI1 BANF1 BCLAF1 BEND7 BYSL CATSPER1 CCDC33 CCNL2 CD33 CEP70 CERS4 CISD2 CLEC14A COMT COPS6 CPLX4 CREB3 CTNNBIP1 CXorf66 DPPA4 EFHC2 ERMAP FAM209A FATE1 GMCL1 GOLM2 GORAB GPR152 GRAMD2A HSF2BP INCA1 KASH5 KCNJ12 KCNJ18 KCNJ8 KCNN3 KIF9 KIR2DL3 LIME1 LMNA LMO7 LPL LUZP4 MAB21L3 MAPK6 MEOX1 MEOX2 MMGT1 MRPL45 MTERF4 MTNR1A NCAPH2 NF2 NPDC1 PAK5 PIMREG PSME1 REL RNASEH1 RNF123 SH3GL2 SH3GL3 SLC10A1 SLC35H1 SOWAHB SRC SSMEM1 STX1A SYNE1 TCF23 TMEM174 TMEM200A TMEM201 TMEM52B TMEM80 TMX2 TRAF3IP3 TRIM42 VAV1 WEE2-AS1 YTHDC1 ZFP1 ZFP57 ZFP64 ZNF165 ZNF232 ZNF329 ZNF341 ZNF398 ZNF549 ZNF774
Entrez ID		3764	2010
HPRD ID		02962	02309
Ensembl ID		ENSG00000121361	ENSG00000102119
Uniprot IDs		Q15842	P50402
PDB IDs			1JEI 2ODC 2ODG 6GHD 6RPR 7NDY
Enriched GO Terms of Interacting Partners?		Inward Rectifying Potassium Channel ATP-activated Inward Rectifier Potassium Channel Activity Potassium Ion Import Across Plasma Membrane ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Inorganic Cation Import Across Plasma Membrane Action Potential Sulfonylurea Receptor Activity Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Potassium Ion-transporting ATPase Complex Regulation Of Potassium Ion Transport Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Transmembrane Transporter Binding Inward Rectifier Potassium Channel Activity Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Response To ATP System Process Positive Regulation Of Potassium Ion Transport Inorganic Ion Transmembrane Transport Regulation Of Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Negative Regulation Of Insulin Secretion ABC-type Transporter Activity T-tubule Negative Regulation Of Peptide Secretion Regulation Of Monoatomic Ion Transmembrane Transport Cardiac Conduction Response To Xenobiotic Stimulus Monoatomic Ion Transport Regulation Of Metal Ion Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Hormone Secretion TMEM240-body Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Negative Regulation Of Protein Secretion Positive Regulation Of Uterine Smooth Muscle Relaxation Negative Regulation Of Neuroblast Migration Potassium Channel Activity Regulation Of Protein Transport Transmembrane Transport Relaxation Of Skeletal Muscle Sarcolemma Regulation Of Establishment Of Protein Localization Regulation Of System Process	Protein Binding Inward Rectifier Potassium Channel Activity Fc-gamma Receptor Signaling Pathway
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