SLC6A5

Description		solute carrier family 6 member 5
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Dense Core Granule Synapse
	Molecular Function	Symporter Activity Glycine:sodium Symporter Activity Transmembrane Transporter Activity Metal Ion Binding
	Biological Process	Neurotransmitter Transport Chemical Synaptic Transmission Sodium Ion Transmembrane Transport Synaptic Transmission, Glycinergic Glycine Import Across Plasma Membrane
Pathways		SLC-mediated transport of neurotransmitters Defective SLC6A5 causes hyperekplexia 3 (HKPX3)
Drugs
Diseases		Hyperekplexia
GWAS		Carotid intima media thickness (maximum) ( 31801372) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Metabolite levels ( 23823483) Obesity-related traits ( 23251661)
Interacting Genes		3 interacting genes: LNX1 SDCBP STX1A
Entrez ID		9152
HPRD ID		08378
Ensembl ID		ENSG00000165970
Uniprot IDs		Q4VAM4 Q4VAM6 Q9Y345
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Exocytosis Interleukin-5 Receptor Binding Positive Regulation Of Exocytosis Interleukin-5 Receptor Complex Positive Regulation Of Extracellular Exosome Assembly Nuclear Membrane Syndecan Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Myosin Head/neck Binding Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Positive Regulation Of Secretion Positive Regulation Of Secretion By Cell Regulation Of Extracellular Exosome Assembly Identical Protein Binding ATP-dependent Protein Binding Response To Gravity Chloride Channel Inhibitor Activity Substrate-dependent Cell Migration, Cell Extension Actomyosin Synaptic Vesicle Docking Regulation Of Norepinephrine Secretion Positive Regulation Of Catecholamine Secretion Regulation Of Synaptic Vesicle Priming SNARE Complex Assembly Localization Within Membrane Negative Regulation Of Receptor Internalization Positive Regulation Of Exosomal Secretion Regulation Of Vesicle-mediated Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium Channel Inhibitor Activity Synapse Maturation Regulation Of Secretion By Cell Regulation Of Exosomal Secretion Positive Regulation Of Neurotransmitter Secretion Cytoskeletal Anchor Activity Regulation Of Secretion Myosin Binding Protein Modification By Small Protein Conjugation Presynaptic Active Zone Membrane Positive Regulation Of Transport Frizzled Binding Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Receptor-mediated Endocytosis Calcium-ion Regulated Exocytosis Post-translational Protein Modification Vesicle Docking Involved In Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Catecholamine Secretion
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