SRPK2 and BRD3

Number of citations of the paper that reports this interaction (PMID 23602568)
8

Data Source:
BioGRID (enzymatic study)

		SRPK2	BRD3
Gene Name		SRSF protein kinase 2	bromodomain containing 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleus
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding 14-3-3 Protein Binding	Chromatin Binding Protein Binding Lysine-acetylated Histone Binding
	Biological Process	Spliceosomal Complex Assembly Angiogenesis Protein Phosphorylation Positive Regulation Of Cell Proliferation RNA Splicing Positive Regulation Of Gene Expression Cell Differentiation Nuclear Speck Organization Intracellular Signal Transduction Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Cell Cycle Regulation Of MRNA Splicing, Via Spliceosome	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification
Pathways
Drugs
Diseases
GWAS		Myopia (pathological) ( 23049088)	Platelet counts ( 22139419)
Protein-Protein Interactions		177 interactors: ABL1 ACIN1 ADPRH AES AHCYL1 ALKBH3 AMMECR1L APEX1 APOBEC3C APP ARGLU1 ARHGAP12 ARL6IP4 ARPC1B ATAT1 AURKA BAIAP2 BRD3 C16orf78 C17orf85 C18orf25 C1orf35 C4orf46 CACNG2 CAND1 CASK CBLN4 CBX5 CCDC28A CCDC97 CCM2 CDC42EP4 CDK7 CHD2 CHERP CHTOP CHUK CLDN19 CLK1 CLK2 CLK3 CSAG1 CTNNBL1 DAW1 DBF4B DDX21 DDX46 DDX6 DHX8 DNAJC8 DRAP1 DRG1 EGLN2 EIF1AY ENOX2 EPB41L1 EPB41L4A EPS8L3 ERCC3 ERN1 EVI5L FAM76B FAM90A1 FGF12 FOXN3 FXR2 GABARAP GABARAPL1 GPR114 GTF2E1 HBS1L HIRIP3 HMGN3 HNRNPC HOMER3 IFIT5 KCNN2 LCA5 LCE3D LRRN4CL LUC7L LUC7L2 LUC7L3 LUZP4 MAB21L2 MAGEB1 MAPKAPK5 MARCH10 MCOLN3 MDK MPP3 MRPS6 NCK2 NELFE NGLY1 NOP16 NPM2 NSMCE4A NSRP1 NUP50 NXT2 OCEL1 PABPC4 PAK4 PDE7B PELI1 POLB PPIA PPIL1 PRKAA1 PRPF38A PRPF40A PSMA3 PTBP1 RBM15 RBM23 RBM39 RBM8A RIT1 RIT2 RNF4 RNPS1 RPL22 RPL39L RPL41 RSRC1 RSRC2 RSRP1 RTF1 RWDD2B SDR42E1 SEC23B SLAIN2 SNIP1 SNRNP27 SNRNP35 SNRNP70 SNURF SREK1 SRI SRRM1 SRSF1 SRSF12 SRSF3 SRSF5 SRSF7 SRSF8 SRSF9 STON1 SUPT16H TAF7L TCOF1 TDP2 TLE4 TNFRSF10C TNIP2 TPD52 TRA2A TRA2B TRIM41 TTN U2AF1 U2AF2 UBD UBE2E2 VAV2 VIMP VRK1 WDR5 YPEL2 YPEL3 YTHDC1 YWHAB ZMAT4 ZRANB2 ZRSR2 ZSCAN9	6 interactors: APP BRD7 MAP1LC3B MYC SPP1 SRPK2
Entrez ID		6733	8019
HPRD ID		04280	03327
Ensembl ID		ENSG00000135250	ENSG00000169925
Uniprot IDs		P78362	Q15059
PDB IDs		2X7G	2E7N 2NXB 2OO1 2YW5 3S91 3S92
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing Gene Expression RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Cellular Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing DNA-templated Transcription, Termination Termination Of RNA Polymerase II Transcription MRNA 3'-end Processing MRNA Export From Nucleus MRNA Transport RNA Export From Nucleus RNA 3'-end Processing RNA Transport Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Localization Nuclear Export MRNA Splice Site Selection Negative Regulation Of RNA Splicing Spliceosomal Complex Assembly Nucleocytoplasmic Transport Nuclear Transport Cellular Process RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Alternative MRNA Splicing, Via Spliceosome Cytoplasmic Transport Ribonucleoprotein Complex Assembly Transcription, DNA-templated Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Intracellular Transport Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Establishment Of Localization In Cell Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle	Regulation Of Cell Cycle Positive Regulation Of Gene Expression Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Nuclear Speck Organization Response To Stress Cellular Response To Stimulus Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Synaptic Growth At Neuromuscular Junction Fibroblast Apoptotic Process Notch Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Peptidase Activity Transition Metal Ion Homeostasis Collateral Sprouting In Absence Of Injury Negative Regulation Of Neuron Differentiation Regulation Of Chromosome Organization Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Monocyte Differentiation Negative Regulation Of Collateral Sprouting Axon Choice Point Recognition Positive Regulation Of Cell Proliferation Involved In Kidney Development Response To Stimulus Negative Regulation Of Axon Regeneration Positive Regulation Of Cellular Protein Metabolic Process Wnt Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Positive Regulation Of Proteolysis Neuron Remodeling Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Development Response To Light Stimulus Positive Regulation Of Transcription, DNA-templated Defense Response Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Monocyte Differentiation Regulation Of Endopeptidase Activity Regulation Of Cellular Amino Acid Metabolic Process RNA Metabolic Process Cell Communication Positive Regulation Of Bone Resorption Regulation Of Cell Proliferation Cellular Metal Ion Homeostasis
Tagcloud ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk1 stringent sty u1 uniquely ww	acquired bet breast classic degrader effort epigenomic eralpha estrogen facilitates frontline fulvestrant h3k36 jq1 lasting methyltransferase modifiers potently premenopausal recruited regulator regulators screen sirna tam tamoxifen valid whsc1 xenograft
Tagcloud (Difference) ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk1 stringent sty u1 uniquely ww	acquired bet breast classic degrader effort epigenomic eralpha estrogen facilitates frontline fulvestrant h3k36 jq1 lasting methyltransferase modifiers potently premenopausal recruited regulator regulators screen sirna tam tamoxifen valid whsc1 xenograft
Tagcloud (Intersection) ?