SRPK2 and RNPS1

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		SRPK2	RNPS1
Gene Name		SRSF protein kinase 2	RNA binding protein S1, serine-rich domain
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Exon-exon Junction Complex ASAP Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding 14-3-3 Protein Binding	Nucleotide Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Spliceosomal Complex Assembly Angiogenesis Protein Phosphorylation Positive Regulation Of Cell Proliferation RNA Splicing Positive Regulation Of Gene Expression Cell Differentiation Nuclear Speck Organization Intracellular Signal Transduction Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Cell Cycle Regulation Of MRNA Splicing, Via Spliceosome	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Positive Regulation Of Apoptotic Process Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways			Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS		Myopia (pathological) ( 23049088)
Protein-Protein Interactions		177 interactors: ABL1 ACIN1 ADPRH AES AHCYL1 ALKBH3 AMMECR1L APEX1 APOBEC3C APP ARGLU1 ARHGAP12 ARL6IP4 ARPC1B ATAT1 AURKA BAIAP2 BRD3 C16orf78 C17orf85 C18orf25 C1orf35 C4orf46 CACNG2 CAND1 CASK CBLN4 CBX5 CCDC28A CCDC97 CCM2 CDC42EP4 CDK7 CHD2 CHERP CHTOP CHUK CLDN19 CLK1 CLK2 CLK3 CSAG1 CTNNBL1 DAW1 DBF4B DDX21 DDX46 DDX6 DHX8 DNAJC8 DRAP1 DRG1 EGLN2 EIF1AY ENOX2 EPB41L1 EPB41L4A EPS8L3 ERCC3 ERN1 EVI5L FAM76B FAM90A1 FGF12 FOXN3 FXR2 GABARAP GABARAPL1 GPR114 GTF2E1 HBS1L HIRIP3 HMGN3 HNRNPC HOMER3 IFIT5 KCNN2 LCA5 LCE3D LRRN4CL LUC7L LUC7L2 LUC7L3 LUZP4 MAB21L2 MAGEB1 MAPKAPK5 MARCH10 MCOLN3 MDK MPP3 MRPS6 NCK2 NELFE NGLY1 NOP16 NPM2 NSMCE4A NSRP1 NUP50 NXT2 OCEL1 PABPC4 PAK4 PDE7B PELI1 POLB PPIA PPIL1 PRKAA1 PRPF38A PRPF40A PSMA3 PTBP1 RBM15 RBM23 RBM39 RBM8A RIT1 RIT2 RNF4 RNPS1 RPL22 RPL39L RPL41 RSRC1 RSRC2 RSRP1 RTF1 RWDD2B SDR42E1 SEC23B SLAIN2 SNIP1 SNRNP27 SNRNP35 SNRNP70 SNURF SREK1 SRI SRRM1 SRSF1 SRSF12 SRSF3 SRSF5 SRSF7 SRSF8 SRSF9 STON1 SUPT16H TAF7L TCOF1 TDP2 TLE4 TNFRSF10C TNIP2 TPD52 TRA2A TRA2B TRIM41 TTN U2AF1 U2AF2 UBD UBE2E2 VAV2 VIMP VRK1 WDR5 YPEL2 YPEL3 YTHDC1 YWHAB ZMAT4 ZRANB2 ZRSR2 ZSCAN9	34 interactors: ACIN1 CHERP CLK2 DVL2 HEXIM2 HOXD4 LUC7L3 NKTR PIN1 PNN PRPF38A RBM8A SAP18 SART3 SDCBP2 SRP54 SRPK1 SRPK2 SRSF1 SRSF11 SRSF4 SRSF6 TAF2 TRA2A TRA2B TRIM41 U2AF1 UBQLN4 UPF2 YWHAB YWHAG ZBTB14 ZNF473 ZNF490
Entrez ID		6733	10921
HPRD ID		04280	07341
Ensembl ID		ENSG00000135250	ENSG00000205937
Uniprot IDs		P78362	D3DU92 Q15287
PDB IDs		2X7G	4A8X
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing Gene Expression RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Cellular Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing DNA-templated Transcription, Termination Termination Of RNA Polymerase II Transcription MRNA 3'-end Processing MRNA Export From Nucleus MRNA Transport RNA Export From Nucleus RNA 3'-end Processing RNA Transport Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Localization Nuclear Export MRNA Splice Site Selection Negative Regulation Of RNA Splicing Spliceosomal Complex Assembly Nucleocytoplasmic Transport Nuclear Transport Cellular Process RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Alternative MRNA Splicing, Via Spliceosome Cytoplasmic Transport Ribonucleoprotein Complex Assembly Transcription, DNA-templated Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Intracellular Transport Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Establishment Of Localization In Cell Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle	MRNA Processing MRNA Metabolic Process RNA Splicing RNA Processing Gene Expression Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Splicing, Via Spliceosome RNA Metabolic Process Regulation Of MRNA Processing Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA 3'-end Processing Nuclear Export MRNA Transport Nitrogen Compound Metabolic Process RNA Transport RNA Localization Cellular Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleocytoplasmic Transport Nuclear Transport Transcription, DNA-templated RNA Biosynthetic Process Cytoplasmic Transport Intracellular Transport Regulation Of Gene Expression Spliceosomal Complex Assembly Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Ribonucleoprotein Complex Assembly Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Establishment Of Localization In Cell Cellular Localization Macromolecule Biosynthetic Process Regulation Of Metabolic Process MRNA Splice Site Selection Metabolic Process Ribonucleoprotein Complex Biogenesis
Tagcloud ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk1 stringent sty u1 uniquely ww	acinus bcl constructs corepressor demonstrates driven enhances explored inc isoforms manner minigene periodicals physiol promoters ra rar rarbeta repressed responsive retinoic rrm splice splicing stimulates varying weak weaker wiley
Tagcloud (Difference) ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome srpk1 stringent sty u1 uniquely ww	acinus bcl constructs corepressor demonstrates driven enhances explored inc isoforms manner minigene periodicals physiol promoters ra rar rarbeta repressed responsive retinoic rrm splice stimulates varying weak weaker wiley
Tagcloud (Intersection) ?		splicing