HSD17B3 and CTNNA1

Number of citations: 0 (PubMedID 24412244)
Data Source: BioGRID (two hybrid)

		HSD17B3	CTNNA1
Name		hydroxysteroid 17-beta dehydrogenase 3	catenin alpha 1
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Acrosomal Vesicle Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Anchoring Junction Plasma Membrane Protein Complex
	Molecular Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Oxidoreductase Activity Testosterone Dehydrogenase (NADP+) Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity	RNA Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Vinculin Binding Identical Protein Binding Protein-containing Complex Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Androgen Biosynthetic Process Male Genitalia Development Testosterone Biosynthetic Process	Ovarian Follicle Development Apoptotic Process Cell Adhesion Establishment Or Maintenance Of Cell Polarity Smoothened Signaling Pathway Integrin-mediated Signaling Pathway Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Intracellular Protein Localization Male Gonad Development Gap Junction Assembly Cell Migration Axon Regeneration Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Apical Junction Assembly Response To Estrogen Positive Regulation Of Smoothened Signaling Pathway Cell Motility Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Androgen biosynthesis Synthesis of very long-chain fatty acyl-CoAs	Adherens junctions interactions VEGFR2 mediated vascular permeability Myogenesis Myogenesis RHO GTPases activate IQGAPs Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 CDH11 homotypic and heterotypic interactions
Drugs		NADH	None
Diseases		46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)	None
GWAS		Cerebrospinal fluid AB1-42 levels ( 26252872 ) Glomerular filtration rate in chronic kidney disease ( 26420894 ) Letter-number span reordering ( 31596458 )	Femur bone mineral density x serum urate levels interaction ( 34046847 ) General risk tolerance (MTAG) ( 30643258 ) Malaria ( 31844061 ) Schizophrenia ( 25056061 )
Novel Interactors		None recorded	1 novel interactors: CDK6
Interacting Genes		9 interacting genes: BRAF BUB1 CDH1 CTNNA1 DLC1 ERBB2 MCC MLH3 SMAD2	55 interacting genes: ACTN1 AFDN AJUBA AKT1 ALDOB APP ARMC8 BAAT CA9 CCDC180 CDC42 CDH1 CDH15 CDH2 CDH3 CDH5 CSNK2A1 CTBP1 CTNNB1 CTSV DLG1 DYRK1A EIF4ENIF1 F2RL1 FBP1 FBP2 FRAT2 HRAS HSD17B3 HSPA13 JUP LRATD2 MAP2K1 MTNR1A MTNR1B NANS PKD1 PSEN1 RBM26 RNF10 SASH1 SFRP2 SFRP4 SMAD1 SPTAN1 SPTBN1 STX17 TDRD7 TJP1 TJP2 UBE2I VCL ZGPAT ZNF189 ZNF510
Entrez ID		3293	1495
HPRD ID		05716	00285
Ensembl ID		ENSG00000130948	ENSG00000044115
Uniprot IDs		P37058 Q6FH62	A0A384MDY0 B4DKT9 B4DU00 G3XAM7 P35221
PDB IDs		Not available	1H6G 4EHP 4IGG 6UPV 6V2O 6V2P 7UTJ 9BL2 9BL3 9BL4
GO Terms Enriched among Interactors		Negative Regulation Of Locomotion Negative Regulation Of Cell Motility Cellular Response To Indole-3-methanol Response To Indole-3-methanol Flotillin Complex Negative Regulation Of Cell Migration Gamma-catenin Binding Cell Junction Organization Regulation Of Locomotion Animal Organ Morphogenesis Regulation Of Cell Motility Catenin Complex Lamellipodium Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Multicellular Organismal Process Animal Organ Development Regulation Of Cell Communication Regulation Of Signaling Cell Junction Assembly Negative Regulation Of Cell Differentiation Negative Regulation Of Cell Development Cortical Actin Cytoskeleton Response To Alcohol Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Regulation Of Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Negative Regulation Of Cell Adhesion Regulation Of Cell Development Regulation Of Cell Differentiation ERBB Signaling Pathway Regulation Of Neurogenesis Regulation Of Cell Population Proliferation Intracellular Signal Transduction Regulation Of Cell Migration Regulation Of Stress Fiber Assembly Identical Protein Binding Negative Regulation Of Developmental Process Intracellular Protein Localization Anchoring Junction ERBB3:ERBB2 Complex Regulation Of Rho Protein Signal Transduction Homomeric SMAD Protein Complex Hindbrain Morphogenesis Chiasma Ruffle Membrane Regulation Of Nervous System Development Beta-catenin Binding	Cell-cell Junction Organization Cell Junction Organization Adherens Junction Cadherin Binding Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Assembly Cell Junction Cell-cell Adhesion Catenin Complex Cell-cell Junction Cell-cell Adhesion Mediated By Cadherin Alpha-catenin Binding Anchoring Junction Cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Fascia Adherens Anatomical Structure Morphogenesis Regulation Of Cell Motility Regulation Of Protein Localization Glutamatergic Synapse Regulation Of Locomotion Beta-catenin Binding Regulation Of Cell Migration Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Plasma Membrane Cellular Response To Indole-3-methanol Regulation Of Supramolecular Fiber Organization Cell Development Regulation Of Cell Population Proliferation Response To Indole-3-methanol Cytoplasm Cortical Actin Cytoskeleton Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Gene Expression Regulation Of DNA-templated Transcription Developmental Process Regulation Of RNA Biosynthetic Process Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Regulation Of Multicellular Organismal Development Positive Regulation Of Angiogenesis Positive Regulation Of Macromolecule Biosynthetic Process Protein Kinase Binding Fructose 1,6-bisphosphate Metabolic Process Regulation Of RNA Metabolic Process