HSD17B3

Name	hydroxysteroid 17-beta dehydrogenase 3
Structure	No pdb structure
Interactors	9 interactors: BRAF BUB1 CDH1 CTNNA1 DLC1 ERBB2 MCC MLH3 SMAD2
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Oxidoreductase Activity Testosterone Dehydrogenase (NADP+) Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Androgen Biosynthetic Process Male Genitalia Development Testosterone Biosynthetic Process
Pathways	Androgen biosynthesis Synthesis of very long-chain fatty acyl-CoAs
Drugs	NADH
Diseases	46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS	Cerebrospinal fluid AB1-42 levels ( 26252872 ) Glomerular filtration rate in chronic kidney disease ( 26420894 ) Letter-number span reordering ( 31596458 )
Entrez ID	3293
HPRD ID	05716
Ensembl ID	ENSG00000130948
Uniprot IDs	P37058 Q6FH62
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Negative Regulation Of Locomotion Negative Regulation Of Cell Motility Cellular Response To Indole-3-methanol Response To Indole-3-methanol Flotillin Complex Negative Regulation Of Cell Migration Gamma-catenin Binding Cell Junction Organization Regulation Of Locomotion Animal Organ Morphogenesis Regulation Of Cell Motility Catenin Complex Lamellipodium Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Multicellular Organismal Process Animal Organ Development Regulation Of Cell Communication Regulation Of Signaling Cell Junction Assembly Negative Regulation Of Cell Differentiation Negative Regulation Of Cell Development Cortical Actin Cytoskeleton Response To Alcohol Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Regulation Of Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Negative Regulation Of Cell Adhesion Regulation Of Cell Development Regulation Of Cell Differentiation ERBB Signaling Pathway Regulation Of Neurogenesis Regulation Of Cell Population Proliferation Intracellular Signal Transduction Regulation Of Cell Migration Regulation Of Stress Fiber Assembly Identical Protein Binding Negative Regulation Of Developmental Process Intracellular Protein Localization Anchoring Junction ERBB3:ERBB2 Complex Regulation Of Rho Protein Signal Transduction Homomeric SMAD Protein Complex Hindbrain Morphogenesis Chiasma Ruffle Membrane Regulation Of Nervous System Development Beta-catenin Binding