TENT5A and HTRA1

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		TENT5A	HTRA1
Description		terminal nucleotidyltransferase 5A	HtrA serine peptidase 1
Image
GO Annotations	Cellular Component	Cytoplasm	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Transferase Activity Nucleotidyltransferase Activity Poly(A) RNA Polymerase Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Growth Factor Binding Identical Protein Binding Molecular Function Activator Activity
	Biological Process	Response To Bacterium Regulation Of Ossification Positive Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation MRNA Stabilization	Placenta Development Proteolysis Programmed Cell Death Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Apoptotic Process Chorionic Trophoblast Cell Differentiation
Pathways			Degradation of the extracellular matrix
Drugs
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Appendicular lean mass ( 33097823)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 20861866 21665990 22694956 32741009 23326517 23455636 23536807) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (MTAG) ( 32277175) Age-related macular degeneration (wet) ( 17053108) Coronary artery disease ( 33020668 29212778) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Diverticular disease ( 30177863) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) Laterality in neovascular age-related macular degeneration ( 28775256) Lung function (FEV1/FVC) ( 30804560 30061609) Migraine ( 27322543) Myocardial infarction ( 33532862) Neovascular age-related macular degeneration ( 28703135) Refractive error ( 32231278) Systolic blood pressure ( 30578418 30224653) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		32 interacting genes: ARID5A ATXN1 BAG6 BCCIP BHLHE40 CD93 COL4A2 DMRTB1 DYNC1H1 EGLN2 GLIS2 HDLBP HTRA1 HYPK KEAP1 KRTAP26-1 NR2F2 PSG3 RHOXF2 RIN3 RNF14 RNF44 ROR2 SNRPC SPINT1 TBX4 TENT5B TNS2 TOLLIP YPEL3 ZC3H10 ZFYVE9	22 interacting genes: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM107A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 LTBP1 MAPT NOS3 PARD6B RPS6KA1 TENT5A XIAP
Entrez ID		55603	5654
HPRD ID		13311	03725
Ensembl ID		ENSG00000112773	ENSG00000166033
Uniprot IDs		Q96IP4	Q92743
PDB IDs		8EXE 8EXF	2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ 6Z0E 6Z0X 6Z0Y 7SJN 7SJO 7SJP 8SDM 8SDP 8SE7 8SE8
Enriched GO Terms of Interacting Partners?			Cartilage Development Fibrillar Collagen Trimer Platelet-derived Growth Factor Binding Chondrocyte Differentiation Endoplasmic Reticulum Lumen Endochondral Ossification Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Cell Migration Ossification Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Cell Motility Identical Protein Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Locomotion Blood Vessel Development Anatomical Structure Morphogenesis Lipoprotein Particle Binding Regulation Of Protein Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Communication Negative Regulation Of Apoptotic Process Regulation Of Signaling Collagen Fibril Organization Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Cell-cell Signaling Negative Regulation Of Long-term Synaptic Potentiation Regulation Of SMAD Protein Signal Transduction Embryonic Skeletal Joint Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Multicellular Organismal Process Extracellular Region Signaling Collagen Trimer Cell Communication Positive Regulation Of Developmental Process Extracellular Matrix Pulmonary Valve Morphogenesis Negative Regulation Of Platelet Activation Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Nitric Oxide Mediated Signal Transduction Cartilage Development Involved In Endochondral Bone Morphogenesis Lung Development Regulation Of Programmed Cell Death Limb Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of BMP Signaling Pathway
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