HGFAC and KLKB1

Number of citations of the paper that reports this interaction (PubMedID 8226803)
0

Data Source:
HPRD (in vitro)

		HGFAC	KLKB1
Description		HGF activator	kallikrein B1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Rough Endoplasmic Reticulum Cytosol	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis Blood Coagulation Zymogen Activation	Factor XII Activation Proteolysis Inflammatory Response Blood Coagulation Hemostasis Zymogen Activation Plasminogen Activation Fibrinolysis Positive Regulation Of Fibrinolysis
Pathways		MET Receptor Activation	Intrinsic Pathway of Fibrin Clot Formation Activation of Matrix Metalloproteinases Defective factor XII causes hereditary angioedema Defective SERPING1 causes hereditary angioedema
Drugs			Zinc Ecallantide Human C1-esterase inhibitor Conestat alfa Gabexate Zinc acetate Zinc chloride Zinc sulfate, unspecified form Lanadelumab Berotralstat
Diseases			Fletcher factor deficiency; Prekallikrein deficiency
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31015462 31152163) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Gamma glutamyl transferase levels ( 29403010 33339817) Height ( 31562340 29782485) Hepatocyte growth factor levels ( 25998175 27989323) Inflammatory bowel disease ( 26192919) Iron status biomarkers (total iron binding capacity) ( 33536631) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Mean spheric corpuscular volume ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Pulse pressure ( 27841878 30578418) Serum total protein levels ( 29403010) Triglyceride levels ( 32203549 30698716 29403010 33339817 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531)	Apolipoprotein A-IV levels ( 27412012) B-type natriuretic peptide levels ( 25561047) Cardiac troponin-I levels ( 31014085) Circulating chromogranin peptide levels ( 28011710) Circulating vasoactive peptide levels ( 23381795) Glycine levels ( 30837465) L-arginine levels ( 27656708) Metabolic traits ( 21886157) Metabolite levels ( 22916037 22286219) Obesity-related traits ( 23251661) Plasma renin activity levels ( 25477429) Response to statin therapy ( 20339536) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 24625756 23093944 33031748) Venous thromboembolism ( 30659681)
Interacting Genes		10 interacting genes: APPBP2 CCHCR1 F2 GOLM1 HGF KLKB1 SLC30A2 SPINT1 SPINT2 VSIG1	8 interacting genes: F12 HGF HGFAC IGFBP3 KNG1 MST1 SERPINA5 TFPI2
Entrez ID		3083	3818
HPRD ID		05184	01971
Ensembl ID		ENSG00000109758	ENSG00000164344
Uniprot IDs		D6RAR4 Q04756	A8K9A9 B4DMX2 E9PBC5 P03952
PDB IDs		1YBW 1YC0 2R0K 2R0L 2WUB 2WUC 3K2U	2ANW 2ANY 4OGX 4OGY 5F8T 5F8X 5F8Z 5TJX 6I44 6O1G 6O1S 6T7P 7N7X 7QOX 8A3Q 8FGX
Enriched GO Terms of Interacting Partners?		Regulation Of Fibrinolysis Serine-type Endopeptidase Activity Fibrinolysis Cell Morphogenesis Negative Regulation Of Neural Precursor Cell Proliferation Cellular Response To BMP Stimulus Epithelial Cell Morphogenesis Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Regulation Of Glial Cell Differentiation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Extracellular Space Cellular Response To Growth Factor Stimulus Response To Growth Factor Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Endopeptidase Activity Factor XII Activation Tube Closure Serine-type Endopeptidase Inhibitor Activity Neural Tube Closure Regulation Of Neural Precursor Cell Proliferation Regulation Of Gliogenesis Coagulation Blood Coagulation Hemostasis Peptidase Inhibitor Activity Zinc Export Across Plasma Membrane Epithelial Cell Morphogenesis Involved In Placental Branching Serine-type Peptidase Activity Thrombospondin Receptor Activity Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of Fibrinolysis Zinc Ion Import Into Lysosome Tube Formation Neutrophil-mediated Killing Of Gram-negative Bacterium Regulation Of Wound Healing Zinc:proton Antiporter Activity Proteolysis Growth Factor Activity Extracellular Region Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Response To Wounding Regulation Of Branching Involved In Salivary Gland Morphogenesis Hepatocyte Growth Factor Receptor Signaling Pathway Vacuolar Transmembrane Transport	Extracellular Space Extracellular Region Coagulation Blood Coagulation Hemostasis Extracellular Matrix Regulation Of Body Fluid Levels Peptidase Inhibitor Activity Serine-type Endopeptidase Activity Rough Endoplasmic Reticulum Zymogen Activation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Platelet Alpha Granule Lumen Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Serine-type Endopeptidase Inhibitor Activity Endopeptidase Activity Plasma Kallikrein-kinin Cascade Factor XII Activation Regulation Of Glucose Metabolic Process Seminal Clot Liquefaction Proteolysis Insulin-like Growth Factor Binding Protein Complex Platelet Dense Tubular Network Serine-type Peptidase Activity Regulation Of Wound Healing Positive Regulation Of Fibrinolysis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor Ternary Complex Acrosin Binding Heparin Binding Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of Response To Wounding Epithelial Cell Proliferation Protein Processing Regulation Of Protein Metabolic Process
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