HGFAC and KLKB1

Number of citations of the paper that reports this interaction (PMID 8226803)
13

Data Source:
HPRD (in vitro)

		HGFAC	KLKB1
Gene Name		HGF activator	kallikrein B, plasma (Fletcher factor) 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Proteolysis	Factor XII Activation Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Zymogen Activation Plasminogen Activation Fibrinolysis Positive Regulation Of Fibrinolysis
Pathways			Intrinsic Pathway Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS			Circulating vasoactive peptide levels ( 23381795) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Obesity-related traits ( 23251661) Response to statin therapy ( 20339536)
Protein-Protein Interactions		5 interactors: F2 HGF KLKB1 SPINT1 SPINT2	8 interactors: F12 HGF HGFAC IGFBP3 KNG1 MST1 SERPINA5 TFPI2
Entrez ID		3083	3818
HPRD ID		05184	01971
Ensembl ID		ENSG00000109758	ENSG00000164344
Uniprot IDs		D6RAR4 Q04756	P03952
PDB IDs		1YBW 1YC0 2R0K 2R0L 2WUB 2WUC 3K2U	2ANW 2ANY
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Processing Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Fibrinolysis Regulation Of Proteolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Fibrinolysis Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity Negative Regulation Of Blood Coagulation Blood Coagulation Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Body Fluid Levels Regulation Of Phosphatidylinositol 3-kinase Signaling Wound Healing Regulation Of Blood Coagulation Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Wounding Negative Regulation Of Cellular Metabolic Process Regulation Of Wound Healing Negative Regulation Of Catalytic Activity Factor XII Activation Protein Activation Cascade Platelet Activation Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Myoblast Proliferation Positive Regulation Of Fibrinolysis Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Plasminogen Activation Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of Myelination Plasma Kallikrein-kinin Cascade Branching Involved In Labyrinthine Layer Morphogenesis Negative Regulation Of Fibrinolysis Positive Regulation Of Neuron Projection Regeneration Movement Of Cell Or Subcellular Component Extracellular Matrix Organization	Regulation Of Protein Processing Blood Coagulation Hemostasis Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Response To Wounding Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity Regulation Of Cellular Protein Metabolic Process Blood Coagulation, Intrinsic Pathway Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Cellular Metabolic Process Platelet Degranulation Regulation Of Blood Coagulation Factor XII Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Wound Healing Positive Regulation Of Cell Death Regulation Of Cell Death Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Myoblast Proliferation Positive Regulation Of Fibrinolysis Protein Activation Cascade Positive Regulation Of Plasminogen Activation Regulation Of Metabolic Process Platelet Activation Regulation Of Extrinsic Apoptotic Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Response To Stress Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Primitive Hemopoiesis
Tagcloud ?		ascertain biovu chance clinician cngb3 compelling convulsions emr f5 gpr98 homozygotes inferred inheritance macular maf mendelian nssnp nssnps omim permuted platforms refine rs13157270 rs16844401 rs3735972 rs6031 synonymous twleve vanderbilt	0x10 18x10 75x10 americans ancestry architecture arr blacks bnp cardioprotective checked cogent consortium copies directions dosages echogen gwa imputed logarithmically lvm motivate natriuretic nppb relations residuals rs198389 rs3733402 whites
Tagcloud (Difference) ?		ascertain biovu chance clinician cngb3 compelling convulsions emr f5 gpr98 homozygotes inferred inheritance macular maf mendelian nssnp nssnps omim permuted platforms refine rs13157270 rs16844401 rs3735972 rs6031 synonymous twleve vanderbilt	0x10 18x10 75x10 americans ancestry architecture arr blacks bnp cardioprotective checked cogent consortium copies directions dosages echogen gwa imputed logarithmically lvm motivate natriuretic nppb relations residuals rs198389 rs3733402 whites
Tagcloud (Intersection) ?