HGFAC

Name	HGF activator
Structure
Interactors	10 interactors: APPBP2 CCHCR1 F2 GOLM1 HGF KLKB1 SLC30A2 SPINT1 SPINT2 VSIG1
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Rough Endoplasmic Reticulum Cytosol
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis Blood Coagulation Zymogen Activation
Pathways	MET Receptor Activation
GWAS	Alanine aminotransferase levels ( 33547301 ) Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 33547301 ) Blood protein levels ( 30072576 ) Coronary artery disease ( 29212778 ) Crohn's disease ( 26192919 ) Estimated glomerular filtration rate ( 31015462 31152163 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 28107422 26561523 ) Gamma glutamyl transferase levels ( 29403010 33339817 ) Height ( 31562340 29782485 ) Hepatocyte growth factor levels ( 25998175 27989323 ) Inflammatory bowel disease ( 26192919 ) Iron status biomarkers (total iron binding capacity) ( 33536631 ) LDL cholesterol levels ( 32203549 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Mean spheric corpuscular volume ( 32888494 ) Platelet count ( 27863252 32888494 ) Plateletcrit ( 27863252 32888494 ) Pulse pressure ( 27841878 30578418 ) Serum total protein levels ( 29403010 ) Triglyceride levels ( 32203549 30698716 29403010 33339817 32154731 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglycerides ( 30275531 )
Entrez ID	3083
HPRD ID	05184
Ensembl ID	ENSG00000109758
Uniprot IDs	D6RAR4 Q04756
PDB IDs	1YBW 1YC0 2R0K 2R0L 2WUB 2WUC 3K2U
GO Terms Enriched among Interactors ?	Regulation Of Fibrinolysis Serine-type Endopeptidase Activity Fibrinolysis Cell Morphogenesis Negative Regulation Of Neural Precursor Cell Proliferation Cellular Response To BMP Stimulus Epithelial Cell Morphogenesis Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Regulation Of Glial Cell Differentiation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Extracellular Space Cellular Response To Growth Factor Stimulus Response To Growth Factor Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Endopeptidase Activity Factor XII Activation Tube Closure Serine-type Endopeptidase Inhibitor Activity Neural Tube Closure Regulation Of Neural Precursor Cell Proliferation Regulation Of Gliogenesis Coagulation Blood Coagulation Hemostasis Peptidase Inhibitor Activity Zinc Export Across Plasma Membrane Epithelial Cell Morphogenesis Involved In Placental Branching Serine-type Peptidase Activity Thrombospondin Receptor Activity Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of Fibrinolysis Zinc Ion Import Into Lysosome Tube Formation Neutrophil-mediated Killing Of Gram-negative Bacterium Regulation Of Wound Healing Zinc:proton Antiporter Activity Proteolysis Growth Factor Activity Extracellular Region Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Response To Wounding Regulation Of Branching Involved In Salivary Gland Morphogenesis Hepatocyte Growth Factor Receptor Signaling Pathway Vacuolar Transmembrane Transport