SORD and KRT5

		SORD	KRT5
Description		sorbitol dehydrogenase	keratin 5
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GO Annotations	Cellular Component	Extracellular Space Mitochondrion Cytosol Cilium Membrane Motile Cilium Mitochondrial Membrane Cell Projection Extracellular Exosome	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome
	Molecular Function	(R,R)-butanediol Dehydrogenase Activity L-iditol 2-dehydrogenase (NAD+) Activity Alcohol Dehydrogenase (NAD+) Activity Zinc Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Carbohydrate Binding Identical Protein Binding D-xylulose Reductase Activity Metal Ion Binding D-sorbitol Dehydrogenase (acceptor) Activity Ribitol 2-dehydrogenase (NAD+) Activity NAD Binding	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis Scaffold Protein Binding
	Biological Process	Glucose Metabolic Process Sorbitol Metabolic Process Sorbitol Catabolic Process D-glucuronate Catabolic Process To D-xylulose 5-phosphate Flagellated Sperm Motility Fructose Biosynthetic Process Xylitol Catabolic Process Xylitol Metabolic Process	Epidermis Development Response To Mechanical Stimulus Regulation Of Cell Migration Keratinization Regulation Of Protein Localization Intermediate Filament Polymerization Intermediate Filament Organization
Pathways		Fructose biosynthesis Formation of xylulose-5-phosphate	Type I hemidesmosome assembly Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs		NADH Cp-166572, 2-Hydroxymethyl-4-(4-N,N-Dimethylaminosulfonyl-1-Piperazino)-Pyrimidine	Zinc Zinc acetate
Diseases			Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic Dowling-Degos disease
GWAS		Alzheimer's disease in APOE e4+ carriers ( 25778476)	Basal cell carcinoma ( 24403052 25855136 27539887 31174203 33549134) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)
Interacting Genes		3 interacting genes: CEBPA RELA SHBG	30 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL INCA1 KIFC3 KRT1 KRT13 KRT14 KRT15 KRT18 KRT24 KRT25 KRT27 KRT28 KRT31 KRT32 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT40 PKP2 RNF26 TCHP UBE3A
Entrez ID		6652	3852
HPRD ID		01679	01010
Ensembl ID		ENSG00000140263	ENSG00000186081
Uniprot IDs		Q00796	P13647
PDB IDs		1PL6 1PL7 1PL8	3TNU 6JFV
Enriched GO Terms of Interacting Partners?		Chromatin DNA Binding Response To Tumor Necrosis Factor Histone Deacetylase Binding Cellular Response To Tumor Necrosis Factor Response To Vitamin RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Nutrient Response To Vitamin B2 Liver Development C/EBP Complex Intermediate Filament Polymerization Intermediate Filament Polymerization Or Depolymerization NF-kappaB P50/p65 Complex CHOP-C/EBP Complex Response To Ketone DNA-binding Transcription Factor Binding White Fat Cell Proliferation Response To Steroid Hormone Response To Mechanical Stimulus Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Schwann Cell Differentiation Positive Regulation Of Schwann Cell Differentiation NF-kappaB Complex Prolactin Signaling Pathway Response To Cobalamin Transcription Regulator Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Postsynapse To Nucleus Signaling Pathway Androgen Binding Transcription Cis-regulatory Region Binding Gland Development Response To Phenylpropanoid Ankyrin Repeat Binding Cellular Response To Peptidoglycan Response To Xenobiotic Stimulus Fat Cell Proliferation Cellular Response To Nicotine Urea Metabolic Process HMG Box Domain Binding Protein-containing Complex Binding Regulation Of Protein Catabolic Process Urea Cycle STAT Family Protein Binding Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipoteichoic Acid Response To Peptidoglycan Phosphate Ion Binding Defense Response To Tumor Cell General Transcription Initiation Factor Binding	Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Structural Constituent Of Skin Epidermis Keratin Filament Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Tissue Morphogenesis Epithelial Cell Differentiation Morphogenesis Of An Epithelium Cytoskeleton Organelle Organization Extracellular Exosome Cytosol Anatomical Structure Morphogenesis Epidermis Development Intermediate Filament Cytoskeleton Developmental Process Keratinization Cellular Developmental Process Cell Differentiation Structural Constituent Of Cytoskeleton Cornified Envelope Tissue Development Desmosome Hair Cycle Peptide Cross-linking Arachidonate 12(S)-lipoxygenase Activity Wound Healing Anchoring Junction Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Hair Follicle Morphogenesis Adherens Junction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Establishment Of Skin Barrier Hepoxilin Biosynthetic Process Polymeric Cytoskeletal Fiber Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Skin Epidermis Development Intermediate Filament Bundle Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Lipoxygenase Pathway Negative Regulation Of Cyclin-dependent Protein Kinase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Regulation Of Ventricular Cardiac Muscle Cell Action Potential Keratinocyte Differentiation Desmosome Organization Scaffold Protein Binding
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