BLK and SKAP2

Number of citations: 46 (PubMedID 29568343)
Data Source: BioGRID (protein complementation assay)

		BLK	SKAP2
Name		BLK proto-oncogene, Src family tyrosine kinase	src kinase associated phosphoprotein 2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity	Protein Binding
	Biological Process	Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Insulin Secretion Intracellular Signal Transduction B Cell Receptor Signaling Pathway	Signal Transduction Negative Regulation Of Cell Population Proliferation B Cell Activation
Pathways		RUNX1 regulates transcription of genes involved in BCR signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Signal regulatory protein family interactions
Drugs		Fostamatinib Zanubrutinib	None
Diseases		Maturity onset diabetes of the young (MODY)	None
GWAS		A body shape index ( 34021172 ) Adult body size ( 32376654 ) Age at first sexual intercourse ( 27089180 ) Albumin-globulin ratio ( 29403010 ) Barrett's esophagus ( 27527254 ) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254 ) Brain morphology (MOSTest) ( 32665545 ) Depression ( 33859377 ) Diastolic blood pressure ( 27841878 27618452 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Estimated glomerular filtration rate ( 31152163 ) Fasting insulin ( 34059833 ) Fish- and plant-related diet ( 32066663 ) General factor of neuroticism ( 30867560 ) General risk tolerance (MTAG) ( 30643258 ) Immune response to smallpox vaccine (IL-6) ( 22610502 ) Kawasaki disease ( 33106546 33772158 22446961 22446962 ) Neurofibrillary tangles ( 31497858 ) Non-albumin protein levels ( 29403010 ) Number of sexual partners ( 30643258 ) Periodontitis (CDC/AAP) ( 24024966 ) Phosphatidylcholine levels ( 31551469 ) Polymyositis ( 26362759 ) Processed meat consumption ( 32066663 ) Pulse pressure ( 27841878 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 21452313 23143596 24390342 19503088 30423114 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 ) Sjögren's syndrome ( 24097067 ) Systemic lupus erythematosus ( 33272962 32771030 28714469 26663301 19165918 19838193 19838195 21408207 23053960 23273568 26316170 26502338 27399966 18204098 ) Systemic lupus erythematosus and Systemic sclerosis ( 23740937 ) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031 ) Systemic sclerosis ( 31672989 29293537 30572963 ) Systolic blood pressure ( 27618452 27841878 28135244 28739976 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic venous disease ( 28374850 ) Disease free survival in colon cancer ( 31811950 ) Erosive tooth wear (severe vs non-severe) ( 29898447 ) Erosive tooth wear (severe vs none or mild) ( 29898447 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) FEV1 ( 30804560 ) Hip index ( 34021172 ) Lung function (FVC) ( 30804560 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Macular thickness ( 30535121 ) Peak expiratory flow ( 30804560 ) Small cell lung carcinoma ( 28604730 ) Survival in colon cancer ( 31811950 ) Systemic lupus erythematosus ( 28714469 )
Interacting Genes		51 interacting genes: AR BCAS2 BCL2 BCL2L1 BCR BIRC2 CBL CCDC33 CD79A CD79B CRKL CTR9 EFS EGFR ERBB2 ERBB3 ERBB4 FBXO7 FCGR2A FCGR2B FLACC1 FXR1 FXR2 GAB1 GRB10 HSF2BP IKZF3 JAKMIP1 KIT MET MID2 PICK1 PIK3R1 PIK3R3 PLCG2 PXN SH2D1B SKAP2 SLA SOCS1 SOCS3 SSBP3 STAP2 STAT3 TDP2 UBE3A ZBTB32 ZBTB42 ZBTB8A ZMAT1 ZNF774	20 interacting genes: APP BLK DNAJB6 EEIG1 FASLG FGR FRK FYB1 FYN HCK KHDRBS1 LCK LYN NCK2 PRAM1 PTK2B SRC SRMS TGFBR1 YES1
Entrez ID		640	8935
HPRD ID		01866	05558
Ensembl ID		ENSG00000136573	ENSG00000005020
Uniprot IDs		P51451 Q05D26	B7Z5R3 O75563
PDB IDs		Not available	3OMH
GO Terms Enriched among Interactors		Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Differentiation Phosphotyrosine Residue Binding B Cell Activation Negative Regulation Of Programmed Cell Death Enzyme-linked Receptor Protein Signaling Pathway Cellular Developmental Process Developmental Process Mononuclear Cell Differentiation Lymphocyte Differentiation Regulation Of Intracellular Signal Transduction Lymphocyte Activation Leukocyte Activation Protein Phosphatase Binding Regulation Of Developmental Process Leukocyte Differentiation Animal Organ Development Regulation Of Immune System Process Positive Regulation Of Intracellular Signal Transduction Male Gonad Development Regulation Of Programmed Cell Death Cell Differentiation Regulation Of Cell Communication Regulation Of Signaling Cell Activation Regulation Of Signal Transduction Protein Tyrosine Kinase Activity Signal Transduction Gonad Development ErbB-3 Class Receptor Binding Intracellular Signal Transduction Ovarian Follicle Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Immune System Process ERBB2 Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Development Basal Plasma Membrane Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Population Proliferation Reproductive Structure Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Development	Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Positive Regulation Of Immune System Process Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Fc Receptor Signaling Pathway Kinase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune Response Immune System Process Protein Phosphorylation Regulation Of Immune Response Phosphorylation Membrane Raft Protein Autophosphorylation Signaling Receptor Activator Activity Antigen Receptor-mediated Signaling Pathway Integrin-mediated Signaling Pathway Signal Transduction T Cell Costimulation Phosphotyrosine Residue Binding Negative Regulation Of Immune Response Ephrin Receptor Signaling Pathway ATP Binding Immune Effector Process Positive Regulation Of Intracellular Signal Transduction Cellular Developmental Process Negative Regulation Of Defense Response Regulation Of Transport Ephrin Receptor Binding Negative Regulation Of Inflammatory Response Nucleotide Binding Transferase Activity Signal Complex Assembly Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process