BLK and BCAS2

Number of citations of the paper that reports this interaction (PubMedID 12406557)
0

Data Source:
HPRD (two hybrid, in vitro)

		BLK	BCAS2
Description		BLK proto-oncogene, Src family tyrosine kinase	BCAS2 pre-mRNA processing factor
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Nucleolus Centrosome Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity	Protein Binding
	Biological Process	Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Insulin Secretion Intracellular Signal Transduction B Cell Receptor Signaling Pathway	RNA Splicing, Via Transesterification Reactions Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Ovarian Follicle Development MRNA Processing RNA Splicing Protein Catabolic Process Oogenesis Oocyte Development Spindle Assembly
Pathways		RUNX1 regulates transcription of genes involved in BCR signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	mRNA Splicing - Major Pathway
Drugs		Fostamatinib Zanubrutinib
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Albumin-globulin ratio ( 29403010) Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Brain morphology (MOSTest) ( 32665545) Depression ( 33859377) Diastolic blood pressure ( 27841878 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Estimated glomerular filtration rate ( 31152163) Fasting insulin ( 34059833) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Immune response to smallpox vaccine (IL-6) ( 22610502) Kawasaki disease ( 33106546 33772158 22446961 22446962) Neurofibrillary tangles ( 31497858) Non-albumin protein levels ( 29403010) Number of sexual partners ( 30643258) Periodontitis (CDC/AAP) ( 24024966) Phosphatidylcholine levels ( 31551469) Polymyositis ( 26362759) Processed meat consumption ( 32066663) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 21452313 23143596 24390342 19503088 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 33272962 32771030 28714469 26663301 19165918 19838193 19838195 21408207 23053960 23273568 26316170 26502338 27399966 18204098) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 31672989 29293537 30572963) Systolic blood pressure ( 27618452 27841878 28135244 28739976) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Autism ( 24189344) Chronotype ( 30696823)
Interacting Genes		51 interacting genes: AR BCAS2 BCL2 BCL2L1 BCR BIRC2 CBL CCDC33 CD79A CD79B CRKL CTR9 EFS EGFR ERBB2 ERBB3 ERBB4 FBXO7 FCGR2A FCGR2B FLACC1 FXR1 FXR2 GAB1 GRB10 HSF2BP IKZF3 JAKMIP1 KIT MET MID2 PICK1 PIK3R1 PIK3R3 PLCG2 PXN SH2D1B SKAP2 SLA SOCS1 SOCS3 SSBP3 STAP2 STAT3 TDP2 UBE3A ZBTB32 ZBTB42 ZBTB8A ZMAT1 ZNF774	82 interacting genes: ACY1 AIMP2 ANKHD1 BLK CCDC120 CCDC17 CNOT4 CPSF7 DMRTB1 DUT ECM1 EIF4ENIF1 EMILIN3 ENKD1 EP300 ESR1 ESR2 FAM86C1P FHIT GOLGA2 HGS HNRNPLL HSF2BP IFI35 IKZF3 KRT20 KRT27 KRT31 KRT34 KRT35 KRT36 KRT37 KRT75 KRTAP19-6 KRTAP8-1 LARP4 LMO1 LMO2 LMO3 LMO4 MBNL1 MED29 MIIP MYOZ3 NIP7 OIP5 PAX5 PCBD2 PFDN5 PGR PLAGL2 PLEKHF2 POT1 PPARG PRRC2B QKI RBM22 RBPMS RPL5 SAXO4 SF1 SLAIN1 SMARCD1 SNRNP200 SNRPC SNW1 SPMIP5 SPMIP6 TCF4 TCHP TFIP11 TP53BP2 TRAF1 TRNAU1AP TXN2 TXNRD2 UBC USHBP1 WDR83 YPEL3 ZMAT5 ZWINT
Entrez ID		640	10286
HPRD ID		01866	05777
Ensembl ID		ENSG00000136573	ENSG00000116752
Uniprot IDs		P51451 Q05D26	B2R7W3 O75934
PDB IDs			5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7W59 7W5A 7W5B 8C6J 8CH6 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Differentiation Phosphotyrosine Residue Binding B Cell Activation Negative Regulation Of Programmed Cell Death Enzyme-linked Receptor Protein Signaling Pathway Cellular Developmental Process Developmental Process Mononuclear Cell Differentiation Lymphocyte Differentiation Regulation Of Intracellular Signal Transduction Lymphocyte Activation Leukocyte Activation Protein Phosphatase Binding Regulation Of Developmental Process Leukocyte Differentiation Animal Organ Development Regulation Of Immune System Process Positive Regulation Of Intracellular Signal Transduction Male Gonad Development Regulation Of Programmed Cell Death Cell Differentiation Regulation Of Cell Communication Regulation Of Signaling Cell Activation Regulation Of Signal Transduction Protein Tyrosine Kinase Activity Signal Transduction Gonad Development ErbB-3 Class Receptor Binding Intracellular Signal Transduction Ovarian Follicle Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Immune System Process ERBB2 Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Development Basal Plasma Membrane Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Population Proliferation Reproductive Structure Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Development	Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Binding Nucleic Acid Binding MRNA Metabolic Process MRNA Processing Structural Molecule Activity Spliceosomal Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Estrogen Response Element Binding RNA Binding RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding RNA Processing Catalytic Step 2 Spliceosome Nucleus Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Nuclear Receptor Activity Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Nuclear Receptor-mediated Signaling Pathway Epithelial Cell Differentiation Nuclear Steroid Receptor Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Morphogenesis Of An Epithelium MRNA Binding DNA-binding Transcription Factor Binding Regulation Of RNA Splicing Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Protein-containing Complex Organization Steroid Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cell Differentiation Supramolecular Fiber Organization Hormone-mediated Signaling Pathway Tissue Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization
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