STK39 and OTOF

Number of citations of the paper that reports this interaction (PubMedID 14563843)
0

Data Source:
BioGRID (two hybrid)

		STK39	OTOF
Description		serine/threonine kinase 39	otoferlin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Cortex Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cell Body	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Transmembrane Transporter Binding Ion Channel Regulator Activity Protein Serine Kinase Activity Transporter Activator Activity Transporter Inhibitor Activity	Calcium Ion Binding Metal Ion Binding
	Biological Process	Response To Dietary Excess Protein Phosphorylation Cell Volume Homeostasis Inflammatory Response Signal Transduction Regulation Of Blood Pressure Positive Regulation Of T Cell Chemotaxis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Intracellular Chloride Ion Homeostasis Negative Regulation Of Transmembrane Transport Intracellular Signal Transduction Sodium Ion Transmembrane Transport Cellular Response To Potassium Ion Maintenance Of Lens Transparency Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Macrophage Activation Positive Regulation Of Potassium Ion Transport Protein Autophosphorylation Regulation Of Inflammatory Response Monoatomic Ion Homeostasis Renal Sodium Ion Absorption Cellular Hyperosmotic Response Cellular Hypotonic Response Potassium Ion Transmembrane Transport Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of P38MAPK Cascade Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Import Across Plasma Membrane Response To Aldosterone Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Chemokine	Sensory Perception Of Sound Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Secretion Membrane Fusion
Pathways			Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Sensory processing of sound by inner hair cells of the cochlea
Drugs		Fostamatinib
Diseases			Deafness, autosomal recessive
GWAS		Blood pressure ( 19114657) Body mass index ( 28552196 28892062) Daytime nap ( 33568662) Macular thickness ( 30535121) Metabolite levels ( 23823483) Parkinson's disease ( 21292315 25064009 27182965 28892059 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Type 1 diabetes ( 32005708) Weight ( 28552196)	Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA/MHPG ratio) ( 23319000) Periodontal microbiota ( 22699663)
Interacting Genes		15 interacting genes: AATK GSN HSPH1 MAPK14 MBP OTOF PRKCQ RELT SLC12A1 SLC12A2 SLC12A6 SPP1 TMEM132D TSC22D2 WNK4	4 interacting genes: BTG3 SRPK2 STK39 USP7
Entrez ID		27347	9381
HPRD ID		09627	04727
Ensembl ID		ENSG00000198648	ENSG00000115155
Uniprot IDs		A0A8V8TKT5 Q9UEW8	Q9HC10
PDB IDs		7O86
Enriched GO Terms of Interacting Partners?		Monoatomic Anion Homeostasis Chloride Ion Homeostasis Chloride:monoatomic Cation Symporter Activity Sodium:potassium:chloride Symporter Activity Chloride Transport Potassium Ion Transmembrane Transporter Activity Cell Volume Homeostasis Potassium Ion Homeostasis Inorganic Anion Transport Monoatomic Anion Transport Potassium Ion Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Intracellular Chloride Ion Homeostasis Response To Osmotic Stress Regulation Of Cell Size Regulation Of Cellular Component Size Inorganic Cation Import Across Plasma Membrane Chloride Transmembrane Transport Symporter Activity Response To Dietary Excess Inorganic Anion Transmembrane Transport Monoatomic Anion Transmembrane Transport Response To Muscle Stretch Protein Serine Kinase Activity Sodium Ion Transmembrane Transport Import Across Plasma Membrane Protein Serine/threonine Kinase Activity Maintenance Of Blood-brain Barrier Aggresome Inorganic Ion Homeostasis Sodium Ion Homeostasis Transmembrane Transporter Activity Sodium Ion Transport Homeostatic Process Multicellular Organismal-level Homeostasis Renal Absorption Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of T-helper 2 Cell Activation Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Positive Regulation Of Cell Volume Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Aldosterone Secretion Protein Kinase Activity Regulation Of Cell-cell Adhesion MAPK Cascade Basolateral Plasma Membrane	Peptidyl-serine Phosphorylation Positive Regulation Of Sodium Ion Import Across Plasma Membrane Regulation Of RNA Splicing Phosphorylation Protein Serine Kinase Activity Nuclear Body Organization Protein Phosphorylation Protein Serine/threonine Kinase Activity R-loop Processing Nuclear Speck Organization Regulation Of Establishment Of Protein Localization To Chromosome Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Monoubiquitinated Protein Deubiquitination Negative Regulation Of Gluconeogenesis Regulation Of Establishment Of Protein Localization To Telomere DNA Alkylation Repair Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Telomere Capping Regulation Of Retrograde Transport, Endosome To Golgi Transcription-coupled Nucleotide-excision Repair K48-linked Deubiquitinase Activity Maintenance Of Lens Transparency Chloride Ion Homeostasis Positive Regulation Of Potassium Ion Import Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Positive Regulation Of Lymphocyte Chemotaxis Hypotonic Response Cellular Hyperosmotic Response Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Transporter Activator Activity Ion Channel Regulator Activity Cellular Response To Potassium Ion Transporter Inhibitor Activity Cellular Hypotonic Response Cellular Response To Chemokine Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis Positive Regulation Of Sodium Ion Transmembrane Transport Potassium Channel Inhibitor Activity Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Regulation Of Potassium Ion Import Negative Regulation Of Sodium Ion Transmembrane Transport Response To Dietary Excess Response To Aldosterone MRNA Processing Response To Potassium Ion Monoatomic Anion Homeostasis Negative Regulation Of Potassium Ion Transmembrane Transport Peptidyl-threonine Phosphorylation
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