STK39 and SLC12A2

Number of citations of the paper that reports this interaction (PMID 14563843)
47

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		STK39	SLC12A2
Gene Name		serine threonine kinase 39	solute carrier family 12 (sodium/potassium/chloride transporter), member 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Basolateral Plasma Membrane Apical Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	Protein Binding Sodium:potassium:chloride Symporter Activity Ammonium Transmembrane Transporter Activity
	Biological Process	Protein Phosphorylation Response To Stress Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Intracellular Signal Transduction Positive Regulation Of Potassium Ion Transport Regulation Of Inflammatory Response Cellular Hypotonic Response Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity	Transport Ion Transport Potassium Ion Transport Sodium Ion Transport Hyperosmotic Response Gamma-aminobutyric Acid Signaling Pathway Ammonium Transport Transepithelial Chloride Transport Multicellular Organism Growth Positive Regulation Of Cell Volume Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Transmembrane Transport Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Transepithelial Ammonium Transport Ammonium Transmembrane Transport Chloride Transmembrane Transport
Pathways			Transport of inorganic cations/anions and amino acids/oligopeptides Cation-coupled Chloride cotransporters SLC-mediated transmembrane transport
Drugs			Potassium Chloride Bumetanide Quinethazone
Diseases
GWAS		Blood pressure ( 19114657) Parkinson's disease ( 21292315)	Brain imaging in schizophrenia (interaction) ( 19023125) Ileal carcinoids ( 21139019)
Protein-Protein Interactions		13 interactors: AATK GSN HSPH1 MAPK14 MBP OTOF PRKCQ RELT SLC12A1 SLC12A2 SLC12A6 SPP1 WNK4	3 interactors: COMMD1 OXSR1 STK39
Entrez ID		27347	6558
HPRD ID		09627	06775
Ensembl ID		ENSG00000198648	ENSG00000064651
Uniprot IDs		Q9UEW8	B7ZM24 P55011 Q53ZR1
PDB IDs
Enriched GO Terms of Interacting Partners?		Chloride Transport System Development Negative Regulation Of Axonogenesis Multicellular Organismal Development Inorganic Anion Transport Anatomical Structure Development Negative Regulation Of Cell Morphogenesis Involved In Differentiation Developmental Process Chloride Transmembrane Transport Negative Regulation Of Neuron Projection Development Negative Regulation Of Cell Projection Organization Response To Stress Regulation Of Axonogenesis Positive Regulation Of Interleukin-4 Production Negative Regulation Of Neuron Differentiation Regulation Of Interleukin-4 Production Response To External Stimulus Potassium Ion Transport Regulation Of Cellular Component Organization Regulation Of Cell Adhesion Organ Development Anion Transport Monovalent Inorganic Cation Transport Sodium Ion Transport Tissue Regeneration Developmental Growth Negative Regulation Of Neurogenesis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Aging Regulation Of Cellular Component Size Negative Regulation Of Cell Development Positive Regulation Of Cell Volume Rubidium Ion Transport Cellular Hypotonic Salinity Response Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury P38MAPK Cascade Anatomical Structure Morphogenesis Metal Ion Transport Regulation Of Cell Growth Execution Phase Of Apoptosis Response To Stimulus Positive Regulation Of Cell Adhesion Regulation Of Neuron Projection Development Response To Osmotic Stress Neurogenesis Negative Regulation Of Developmental Growth Anion Transmembrane Transport Tissue Development Positive Regulation Of T-helper 2 Cell Activation Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity Negative Regulation Of Ion Transport Regulation Of Rubidium Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Hypotonic Response Hypotonic Response Negative Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Cellular Response To Osmotic Stress Negative Regulation Of Transport Regulation Of Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Peptidyl-threonine Phosphorylation Regulation Of Ion Transport Regulation Of Potassium Ion Transport Response To Osmotic Stress Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Signal Transduction By Phosphorylation Negative Regulation Of Sodium Ion Transmembrane Transport Plasma Membrane To Endosome Transport Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Sodium Ion Transport Regulation Of Protein Localization To Cell Surface Copper Ion Homeostasis Positive Regulation Of Potassium Ion Transport Golgi To Plasma Membrane Transport Regulation Of Sodium Ion Transmembrane Transport Peptidyl-amino Acid Modification Response To Abiotic Stimulus Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sodium Ion Transport Protein Phosphorylation Post-Golgi Vesicle-mediated Transport Cellular Response To Stress Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Peptidyl-serine Phosphorylation Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Phosphorylation Intracellular Signal Transduction Transition Metal Ion Homeostasis
Tagcloud ?		atp2b1 atxn2 bdkrb2 cacnb2 csk cyp171a cyp17a1 cyp1a2 eh gwas hfe jan meant mthfr nppa nppb nt5c2 overlapped pharmacogenomics plcd3 plekha7 sh2b3 tbx3 tbx5 ulk3 ulk4 umod wnk4 znf652	arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 strengths tnik trait unanticipated visualizing
Tagcloud (Difference) ?		atp2b1 atxn2 bdkrb2 cacnb2 csk cyp171a cyp17a1 cyp1a2 eh hfe jan meant mthfr nppa nppb nt5c2 overlapped pharmacogenomics plcd3 plekha7 sh2b3 tbx3 tbx5 ulk3 ulk4 umod wnk4 znf652	arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 strengths tnik trait unanticipated visualizing
Tagcloud (Intersection) ?		gwas