STK39

Description		serine/threonine kinase 39
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Cortex Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cell Body
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Transmembrane Transporter Binding Ion Channel Regulator Activity Protein Serine Kinase Activity Transporter Activator Activity Transporter Inhibitor Activity
	Biological Process	Response To Dietary Excess Protein Phosphorylation Cell Volume Homeostasis Inflammatory Response Signal Transduction Regulation Of Blood Pressure Positive Regulation Of T Cell Chemotaxis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Intracellular Chloride Ion Homeostasis Negative Regulation Of Transmembrane Transport Intracellular Signal Transduction Sodium Ion Transmembrane Transport Cellular Response To Potassium Ion Maintenance Of Lens Transparency Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Macrophage Activation Positive Regulation Of Potassium Ion Transport Protein Autophosphorylation Regulation Of Inflammatory Response Monoatomic Ion Homeostasis Renal Sodium Ion Absorption Cellular Hyperosmotic Response Cellular Hypotonic Response Potassium Ion Transmembrane Transport Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of P38MAPK Cascade Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Import Across Plasma Membrane Response To Aldosterone Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Chemokine
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Blood pressure ( 19114657) Body mass index ( 28552196 28892062) Daytime nap ( 33568662) Macular thickness ( 30535121) Metabolite levels ( 23823483) Parkinson's disease ( 21292315 25064009 27182965 28892059 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Type 1 diabetes ( 32005708) Weight ( 28552196)
Novel Interacting Genes		1 novel interacting genes: XRN2
Interacting Genes		15 interacting genes: AATK GSN HSPH1 MAPK14 MBP OTOF PRKCQ RELT SLC12A1 SLC12A2 SLC12A6 SPP1 TMEM132D TSC22D2 WNK4
Entrez ID		27347
HPRD ID		09627
Ensembl ID		ENSG00000198648
Uniprot IDs		A0A8V8TKT5 Q9UEW8
PDB IDs		7O86
Enriched GO Terms of Interacting Partners?		Monoatomic Anion Homeostasis Chloride Ion Homeostasis Chloride:monoatomic Cation Symporter Activity Sodium:potassium:chloride Symporter Activity Chloride Transport Potassium Ion Transmembrane Transporter Activity Cell Volume Homeostasis Potassium Ion Homeostasis Inorganic Anion Transport Monoatomic Anion Transport Potassium Ion Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Intracellular Chloride Ion Homeostasis Response To Osmotic Stress Regulation Of Cell Size Regulation Of Cellular Component Size Inorganic Cation Import Across Plasma Membrane Chloride Transmembrane Transport Symporter Activity Response To Dietary Excess Inorganic Anion Transmembrane Transport Monoatomic Anion Transmembrane Transport Response To Muscle Stretch Protein Serine Kinase Activity Sodium Ion Transmembrane Transport Import Across Plasma Membrane Protein Serine/threonine Kinase Activity Maintenance Of Blood-brain Barrier Aggresome Inorganic Ion Homeostasis Sodium Ion Homeostasis Transmembrane Transporter Activity Sodium Ion Transport Homeostatic Process Multicellular Organismal-level Homeostasis Renal Absorption Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of T-helper 2 Cell Activation Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Positive Regulation Of Cell Volume Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Aldosterone Secretion Protein Kinase Activity Regulation Of Cell-cell Adhesion MAPK Cascade Basolateral Plasma Membrane
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