SLC9A2 and CHP1

Number of citations: 41 (PubMedID 8901634)
Data Source: HPRD (in vitro, in vivo)

		SLC9A2	CHP1
Name		solute carrier family 9 member A2	calcineurin like EF-hand protein 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytoskeleton Plasma Membrane Focal Adhesion Endomembrane System Microtubule Cytoskeleton Membrane Transport Vesicle Membrane Raft Extracellular Exosome Transporter Complex
	Molecular Function	Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity	Protein Kinase Inhibitor Activity Calcium Ion Binding Protein Binding Microtubule Binding Sodium:proton Antiporter Activity Potassium Channel Regulator Activity Kinase Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Regulation Of PH Intracellular Protein Localization Epithelial Cell Differentiation Regulation Of Intracellular PH Transmembrane Transport Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport	Microtubule Bundle Formation Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Protein Export From Nucleus Potassium Ion Transport Small GTPase-mediated Signal Transduction Negative Regulation Of Phosphatase Activity Protein Transport Membrane Docking Cytoplasmic Microtubule Organization Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sodium:proton Antiporter Activity Sodium Ion Transmembrane Transport Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Import Into Nucleus Protein Stabilization Positive Regulation Of Protein Transport Regulation Of Intracellular PH Positive Regulation Of Protein Glycosylation Membrane Organization Membrane Fusion Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Phospholipid Biosynthetic Process Cellular Response To Acidic PH Positive Regulation Of Protein Targeting To Membrane
Pathways		Sodium/Proton exchangers	Hyaluronan degradation
Drugs		None	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Asthma ( 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Delirium ( 29631748 ) Gut microbiota (bacterial taxa) ( 27723756 ) Night sleep phenotypes ( 27126917 ) Plateletcrit ( 32888494 )	Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Essential hypertension (time to event) ( 32589924 ) Estimated glomerular filtration rate ( 31015462 ) Ulcerative colitis ( 28067908 ) White blood cell count ( 32888494 )
Interacting Genes		8 interacting genes: ABL1 CHP1 CHP2 PIK3R1 RASA1 SPTA1 SPTAN1 SRC	10 interacting genes: GAPDH KIF1B PRSS23 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 STK17B UBC
Entrez ID		6549	11261
HPRD ID		02756	06101
Ensembl ID		ENSG00000115616	ENSG00000187446
Uniprot IDs		Q9UBY0	H0YKE7 Q99653
PDB IDs		Not available	2E30 7DSV 7DSX 7X2U
GO Terms Enriched among Interactors		Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Cell-matrix Adhesion Regulation Of Actin Filament-based Process Regulation Of Dephosphorylation Regulation Of Protein-containing Complex Assembly Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell-matrix Adhesion Phosphotyrosine Residue Binding Substrate Adhesion-dependent Cell Spreading Ephrin Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Regulation Of Protein Import Into Nucleus Regulation Of Organelle Organization Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Dephosphorylation Regulation Of Intracellular Transport Regulation Of Cell-substrate Junction Organization Negative Regulation Of Cell Adhesion Spectrin Regulation Of Phosphatase Activity Positive Regulation Of Protein Localization To Nucleus Regulation Of Cell Adhesion Regulation Of Biological Quality Actin Cytoskeleton Organization Regulation Of Nucleocytoplasmic Transport Actin Filament-based Process Regulation Of Actin Filament Polymerization Plasma Membrane Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Localization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Intracellular Protein Transport Cell Activation Involved In Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cell-substrate Adhesion Leukocyte Activation Involved In Immune Response Supramolecular Fiber Organization Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Localization Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Ephrin Receptor Binding	Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Sodium Ion Import Across Plasma Membrane Regulation Of Cellular PH Regulation Of Intracellular PH Antiporter Activity Inorganic Cation Import Across Plasma Membrane Regulation Of PH Sodium Ion Transmembrane Transport Import Across Plasma Membrane Potassium Ion Transmembrane Transport Proton Transmembrane Transport Potassium Ion Transport Sodium Ion Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Cellular Homeostasis Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Apical Plasma Membrane Chemical Homeostasis Monoatomic Ion Transport Transmembrane Transport Homeostatic Process Plasma Membrane Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Regulation Of The Force Of Heart Contraction By Cardiac Conduction Cation-transporting ATPase Complex Regulation Of Biological Quality Recycling Endosome Membrane Membrane Peptidyl-cysteine S-nitrosylase Activity Peptidyl-cysteine S-nitrosylation GAIT Complex Transporter Complex Transepithelial Ammonium Transport Positive Regulation Of The Force Of Heart Contraction Retrograde Neuronal Dense Core Vesicle Transport Glandular Epithelial Cell Development Extracellular Exosome Aspartic-type Endopeptidase Inhibitor Activity