SLC6A9 and NAPA

Data Source: HiPPIP (Novel)

		SLC6A9	NAPA
Name		solute carrier family 6 member 9	NSF attachment protein alpha
Structure			No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Basal Plasma Membrane Postsynaptic Density Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Synaptic Vesicle Membrane Dense Core Granule Asymmetric Synapse Presynaptic Membrane Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Parallel Fiber To Purkinje Cell Synapse	Cytosol Plasma Membrane Membrane Neuromuscular Junction Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Amino Acid:sodium Symporter Activity Glycine Transmembrane Transporter Activity Symporter Activity Glycine:sodium Symporter Activity Transmembrane Transporter Activity	SNARE Binding Soluble NSF Attachment Protein Activity Protein Binding Syntaxin Binding Protein-containing Complex Binding
	Biological Process	Neurotransmitter Uptake Neurotransmitter Transport Amino Acid Transport Glycine Transport Sodium Ion Transmembrane Transport Positive Regulation Of Hemoglobin Biosynthetic Process Regulation Of Synaptic Transmission, Glycinergic Glycine Secretion, Neurotransmission Positive Regulation Of Heme Biosynthetic Process Transport Across Blood-brain Barrier Glycine Import Across Plasma Membrane	Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Brain Development Regulation Of Synaptic Vesicle Priming Protein Transport Synaptic Vesicle Priming Vesicle-mediated Transport Neuron Differentiation Protein-containing Complex Disassembly Synaptic Transmission, Glutamatergic SNARE Complex Disassembly Apical Protein Localization Membrane Fusion
Pathways		SLC-mediated transport of neurotransmitters	COPII-mediated vesicle transport Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
GWAS		Attention deficit hyperactivity disorder or cannabis use ( 30610198 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 29403010 32888494 ) Refractive error ( 32231278 )	Blood protein levels ( 30072576 )
Novel Interactors		3 novel interactors: NAPA PPP2R3B TP53BP1	1 novel interactors: SLC6A9
Interacting Genes		3 interacting genes: GABRR1 PRKCA STX1A	22 interacting genes: APP BNIP1 DSCAM FURIN GNA12 GOSR1 GOSR2 HSPB1 HUNK NSF RIPK4 RTN4 SNAP23 SNAP25 STX12 STX1A STX4 STX5 STX7 STX8 TRPC3 VAMP8
Entrez ID		6536	8775
HPRD ID		03010	04447
Ensembl ID		ENSG00000196517	ENSG00000105402
Uniprot IDs		B7Z3A9 B7Z3W8 B7Z589 P48067	P54920
PDB IDs		6ZBV 6ZPL 8WFI 8WFJ 8WFK 8WFL 9J8B 9J8C 9J8D	Not available
GO Terms Enriched among Interactors		Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of Synaptic Vesicle Priming Presynaptic Active Zone Membrane Protein-containing Complex Binding SNARE Binding Positive Regulation Of Exocytosis Myosin Head/neck Binding Glutamatergic Synapse Presynaptic Membrane Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Membrane Organization Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Soluble NSF Attachment Protein Activity SNARE Complex Disassembly Membrane Fusion Regulation Of Insulin Secretion Protein Kinase C Signaling Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Histone H4K20me Methyltransferase Activity GABA Receptor Activity Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Exocytosis Histone H4K20me2 Reader Activity Desmosome Assembly ATP-dependent Protein Binding Response To Gravity Chloride Channel Inhibitor Activity Ubiquitin-modified Histone Reader Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Trans-synaptic Signaling GABA-A Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Synaptic Signaling GABA-A Receptor Complex Chemical Synaptic Transmission GABA-gated Chloride Ion Channel Activity Regulation Of Hormone Secretion Mitotic Nuclear Membrane Disassembly Diacylglycerol Binding Positive Regulation Of Secretion Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway	SNAP Receptor Activity SNARE Complex Organelle Membrane Fusion Membrane Fusion Organelle Fusion Vesicle Fusion SNARE Binding Membrane Organization Organelle Localization By Membrane Tethering Vesicle Organization Membrane Docking Vesicle Docking Vesicle-mediated Transport Establishment Of Localization In Cell Chloride Channel Inhibitor Activity Protein Transport Syntaxin Binding Establishment Of Protein Localization Secretion By Cell Endomembrane System Intracellular Protein Localization Organelle Localization Intracellular Transport Vesicle Neuron Projection Secretion Exocytosis Intracellular Protein Transport SNARE Complex Assembly Recycling Endosome Cellular Localization Golgi Vesicle Transport Plasma Membrane Endosome Organelle Organization Membrane Neurotransmitter Transport Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Intra-Golgi Vesicle-mediated Transport Regulation Of Protein Localization Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Neuron Recognition Modulation Of Chemical Synaptic Transmission Positive Regulation Of Chemotaxis Positive Regulation Of Synaptic Transmission Positive Regulation Of Regulated Secretory Pathway Protein-containing Complex Organization Heparan Sulfate Binding Regulation Of Protein Localization To Cell Periphery