TUSC3

Gene Name		tumor suppressor candidate 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Oligosaccharyltransferase Complex
	Molecular Function	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Magnesium Ion Transmembrane Transporter Activity
	Biological Process	Protein N-linked Glycosylation Magnesium Ion Transport Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Cell Redox Homeostasis Cognition
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS		Intelligence ( 22449649) Methamphetamine dependence ( 23594818) Pulmonary function decline ( 22424883)
Protein-protein Interactions		2 interactors: BMI1 PPP1CA
Entrez ID		7991
HPRD ID		03228
Ensembl ID		ENSG00000104723
Uniprot IDs		D6RIY7 Q13454
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Immature T Cell Proliferation Cell Division Regulation Of Glycogen Catabolic Process Tube Development Positive Regulation Of T Cell Differentiation In Thymus Segment Specification Rostrocaudal Neural Tube Patterning Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Epithelium Development Negative Regulation Of Signal Transduction Somatic Stem Cell Division Negative Regulation Of Signaling Regulation Of T Cell Differentiation In Thymus Regulation Of Glycogen Biosynthetic Process Histone Ubiquitination Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Glycogen Metabolic Process Positive Regulation Of B Cell Proliferation Stem Cell Division Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of B Cell Proliferation DNA Methylation Neural Tube Patterning Glycogen Metabolic Process Tissue Development Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of B Cell Activation Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Ligase Activity Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway DNA Modification Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Lymphocyte Differentiation Triglyceride Metabolic Process Regulation Of Circadian Rhythm Regulation Of Fibroblast Proliferation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		accommodate anchored away catalyzed cysteine disulfide eukaryotes folding glycoproteins glycosylation groove hetero hydrophobic lumen mixed n33 nonsyndromic oligomer oligosaccharyl opposite orientations ost possesses prefers retardation slowing substrates thioredoxin transferase