MEAF6 and MRGBP

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		MEAF6	MRGBP
Description		MYST/Esa1 associated factor 6	MRG domain binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Chromosome, Centromeric Region Kinetochore Nucleosome Nucleus Nucleoplasm Chromosome Nucleolus NuA4 Histone Acetyltransferase Complex MOZ/MORF Histone Acetyltransferase Complex	Nucleosome Nucleus Nucleoplasm NuA4 Histone Acetyltransferase Complex H4/H2A Histone Acetyltransferase Complex
	Molecular Function	Protein Binding Histone H3K14 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity	Protein Binding
	Biological Process	Regulation Of Cell Growth Regulation Of DNA Replication Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Regulation Of Developmental Process Regulation Of Cell Cycle Regulation Of Hemopoiesis Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Biosynthetic Process Regulation Of Double-strand Break Repair	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		HATs acetylate histones HATs acetylate histones Regulation of TP53 Activity through Acetylation	HATs acetylate histones
Drugs
Diseases
GWAS		Eyebrow thickness ( 26926045)
Interacting Genes		8 interacting genes: CATSPERT CCDC85B FXR2 L3MBTL2 LDOC1 MRGBP PLEKHF2 TRIM54	25 interacting genes: ACTB ACTL6A BRD8 DAPK1 DMAP1 HSPB1 ING1 KRTAP1-1 KRTAP10-7 KRTAP17-1 KRTAP5-7 LRRK2 MEAF6 MFHAS1 MORF4L1 MORF4L2 MSL1 NBPF19 NOTCH2NLA RUVBL1 SH3BP4 TRRAP TUBB VAV2 YEATS4
Entrez ID		64769	55257
HPRD ID		13347	16646
Ensembl ID		ENSG00000163875	ENSG00000101189
Uniprot IDs		Q9HAF1	Q9NV56
PDB IDs			2N1D
Enriched GO Terms of Interacting Partners?			NuA4 Histone Acetyltransferase Complex Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Nucleosome Regulation Of DNA Recombination Positive Regulation Of DNA Repair Regulation Of Double-strand Break Repair Regulation Of DNA Repair Positive Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Chromatin Organization Regulation Of DNA Metabolic Process Swr1 Complex Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Chromatin Remodeling Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nuclear Matrix Positive Regulation Of Stem Cell Population Maintenance Intermediate Filament Regulation Of Stem Cell Population Maintenance Brahma Complex NpBAF Complex GBAF Complex Positive Regulation Of Telomere Maintenance In Response To DNA Damage RSC-type Complex Ino80 Complex Negative Regulation Of GTPase Activity Regulation Of DNA Strand Elongation Syntaxin-1 Binding Structural Constituent Of Cytoskeleton Sin3-type Complex Regulation Of Synaptic Vesicle Endocytosis Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of DNA Replication Regulation Of RNA Biosynthetic Process DNA Repair Regulation Of Nucleotide-excision Repair Regulation Of Macromolecule Biosynthetic Process
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