MRGBP and BRD8

Number of citations of the paper that reports this interaction (PubMedID 12963728)
0

Data Source:
HPRD (in vitro)

		MRGBP	BRD8
Description		MRG domain binding protein	bromodomain containing 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm NuA4 Histone Acetyltransferase Complex H4/H2A Histone Acetyltransferase Complex	Nucleosome Swr1 Complex Nucleus Nucleoplasm Mitochondrion NuA4 Histone Acetyltransferase Complex
	Molecular Function	Protein Binding	Transcription Coactivator Activity Protein Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Chromatin Organization Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		HATs acetylate histones	HATs acetylate histones
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Menarche (age at onset) ( 25231870)
Interacting Genes		25 interacting genes: ACTB ACTL6A BRD8 DAPK1 DMAP1 HSPB1 ING1 KRTAP1-1 KRTAP10-7 KRTAP17-1 KRTAP5-7 LRRK2 MEAF6 MFHAS1 MORF4L1 MORF4L2 MSL1 NBPF19 NOTCH2NLA RUVBL1 SH3BP4 TRRAP TUBB VAV2 YEATS4	13 interacting genes: AGTR1 EP400 EP400P1 FSD2 MCRS1 MIS18A MRGBP PIN1 PPARG RXRA THRB TRRAP WEE1
Entrez ID		55257	10902
HPRD ID		16646	04166
Ensembl ID		ENSG00000101189	ENSG00000112983
Uniprot IDs		Q9NV56	B4DEG9 B4DMS9 B4DN43 Q9H0E9
PDB IDs		2N1D
Enriched GO Terms of Interacting Partners?		NuA4 Histone Acetyltransferase Complex Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Nucleosome Regulation Of DNA Recombination Positive Regulation Of DNA Repair Regulation Of Double-strand Break Repair Regulation Of DNA Repair Positive Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Chromatin Organization Regulation Of DNA Metabolic Process Swr1 Complex Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Chromatin Remodeling Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nuclear Matrix Positive Regulation Of Stem Cell Population Maintenance Intermediate Filament Regulation Of Stem Cell Population Maintenance Brahma Complex NpBAF Complex GBAF Complex Positive Regulation Of Telomere Maintenance In Response To DNA Damage RSC-type Complex Ino80 Complex Negative Regulation Of GTPase Activity Regulation Of DNA Strand Elongation Syntaxin-1 Binding Structural Constituent Of Cytoskeleton Sin3-type Complex Regulation Of Synaptic Vesicle Endocytosis Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of DNA Replication Regulation Of RNA Biosynthetic Process DNA Repair Regulation Of Nucleotide-excision Repair Regulation Of Macromolecule Biosynthetic Process	Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of DNA Metabolic Process NuA4 Histone Acetyltransferase Complex DNA Binding Domain Binding Positive Regulation Of DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Lipoprotein Transport MRNA Transcription By RNA Polymerase II Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Nuclear Receptor Activity Positive Regulation Of Metabolic Process LBD Domain Binding MRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Swr1 Complex Regulation Of DNA Repair Positive Regulation Of DNA Recombination Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Monocyte Differentiation Nucleosome Regulation Of Cell Cycle RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Lipid Metabolic Process Regulation Of Lipid Transport Regulation Of DNA Recombination Negative Regulation Of SMAD Protein Signal Transduction Hormone-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Double-strand Break Repair Peptide Binding Cellular Response To Low-density Lipoprotein Particle Stimulus Regulation Of Macrophage Derived Foam Cell Differentiation Nucleoplasm Regulation Of Metabolic Process Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Chromatin Organization Transcription Coregulator Binding Regulation Of Cholesterol Efflux
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