MRGBP and RUVBL1

Number of citations of the paper that reports this interaction (PubMedID 12963728)
0

Data Source:
HPRD (in vitro)

		MRGBP	RUVBL1
Description		MRG domain binding protein	RuvB like AAA ATPase 1
Image
GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm NuA4 Histone Acetyltransferase Complex H4/H2A Histone Acetyltransferase Complex	Nucleosome Swr1 Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Membrane Nuclear Matrix Nuclear Speck Ino80 Complex NuA4 Histone Acetyltransferase Complex Ciliary Basal Body Extracellular Exosome MLL1 Complex R2TP Complex Protein Folding Chaperone Complex Dynein Axonemal Particle RPAP3/R2TP/prefoldin-like Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Nucleotide Binding TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity TBP-class Protein Binding ADP Binding Cadherin Binding ATPase Binding
	Biological Process	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Box C/D SnoRNP Assembly Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Spermatogenesis Regulation Of Chromosome Organization Regulation Of Apoptotic Process Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Protein Stabilization Cell Division Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Positive Regulation Of Canonical Wnt Signaling Pathway Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		HATs acetylate histones	Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones UCH proteinases Ub-specific processing proteases DNA Damage Recognition in GG-NER Deposition of new CENPA-containing nucleosomes at the centromere
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Gestational age at birth (maternal effect) ( 28877031) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		25 interacting genes: ACTB ACTL6A BRD8 DAPK1 DMAP1 HSPB1 ING1 KRTAP1-1 KRTAP10-7 KRTAP17-1 KRTAP5-7 LRRK2 MEAF6 MFHAS1 MORF4L1 MORF4L2 MSL1 NBPF19 NOTCH2NLA RUVBL1 SH3BP4 TRRAP TUBB VAV2 YEATS4	20 interacting genes: ACTL6A CEP126 CTNNB1 DKC1 FBL FOXP1 LZTR1 MRGBP NEDD4 OFD1 OGT PCBP3 PLG RUVBL2 STOM SUMO2 TAF9 TBP TERT TK1
Entrez ID		55257	8607
HPRD ID		16646	09143
Ensembl ID		ENSG00000101189	ENSG00000175792
Uniprot IDs		Q9NV56	A0A384MTR5 B3KRS7 E7ETR0 Q9Y265
PDB IDs		2N1D	2C9O 2XSZ 5OAF 6FO1 6HTS 6IGM 6K0R 6QI8 6QI9 7AHO 7OLE 7P6X 7ZI4 8QR1 8X15 8X19 8X1C 8XVG 8XVT 9C57 9C62 9EMA 9EMC
Enriched GO Terms of Interacting Partners?		NuA4 Histone Acetyltransferase Complex Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Nucleosome Regulation Of DNA Recombination Positive Regulation Of DNA Repair Regulation Of Double-strand Break Repair Regulation Of DNA Repair Positive Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Chromatin Organization Regulation Of DNA Metabolic Process Swr1 Complex Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Chromatin Remodeling Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nuclear Matrix Positive Regulation Of Stem Cell Population Maintenance Intermediate Filament Regulation Of Stem Cell Population Maintenance Brahma Complex NpBAF Complex GBAF Complex Positive Regulation Of Telomere Maintenance In Response To DNA Damage RSC-type Complex Ino80 Complex Negative Regulation Of GTPase Activity Regulation Of DNA Strand Elongation Syntaxin-1 Binding Structural Constituent Of Cytoskeleton Sin3-type Complex Regulation Of Synaptic Vesicle Endocytosis Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of DNA Replication Regulation Of RNA Biosynthetic Process DNA Repair Regulation Of Nucleotide-excision Repair Regulation Of Macromolecule Biosynthetic Process	Positive Regulation Of Telomere Maintenance NuA4 Histone Acetyltransferase Complex Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance RNA Localization Regulation Of DNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA Metabolic Process Telomere Organization Negative Regulation Of Signal Transduction Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Macromolecule Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomerase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Euchromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process TFIID-class Transcription Factor Complex Binding Box C/D SnoRNP Assembly Ribonucleoprotein Complex Nucleoplasm Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA Recombination RNA Metabolic Process Positive Regulation Of Metabolic Process Nucleus Positive Regulation Of Telomere Maintenance In Response To DNA Damage Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Embryonic Development ATPase Binding Ino80 Complex Regulation Of DNA Repair Regulation Of Programmed Cell Death DNA Biosynthetic Process Regulation Of DNA Strand Elongation Regulation Of Chromosome Organization
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