CMTM5 and APOA4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CMTM5	APOA4
Description		CKLF like MARVEL transmembrane domain containing 5	apolipoprotein A4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Cell Surface Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Synapse Extracellular Exosome Blood Microparticle Extracellular Vesicle
	Molecular Function	Cytokine Activity Protein Binding	Lipid Transporter Activity Copper Ion Binding Protein Binding Phospholipid Binding Lipid Binding Antioxidant Activity Phosphatidylcholine Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity Cholesterol Transfer Activity
	Biological Process	Chemotaxis Signal Transduction Negative Regulation Of Myoblast Differentiation	Innate Immune Response In Mucosa Lipid Transport Response To Stress Response To Lipid Hydroperoxide Leukocyte Cell-cell Adhesion Cholesterol Metabolic Process Positive Regulation Of Triglyceride Catabolic Process Peripheral Nervous System Axon Regeneration Lipid Catabolic Process Removal Of Superoxide Radicals Regulation Of Intestinal Cholesterol Absorption Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Response To Triglyceride Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Assembly Negative Regulation Of Plasma Lipoprotein Oxidation Response To Stilbenoid Lipoprotein Metabolic Process Cholesterol Homeostasis Hydrogen Peroxide Catabolic Process Reverse Cholesterol Transport Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Lipid Homeostasis Acylglycerol Homeostasis Protein-lipid Complex Assembly
Pathways			Chylomicron assembly Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation
Drugs			Zinc Copper Zinc acetate
Diseases
GWAS			Apolipoprotein A-IV levels ( 27412012) Body mass index ( 31978080) Cholesterol, total ( 19060911 20686565) Coronary artery disease ( 29263402) Coronary heart disease ( 21378990) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 26582766 20864672 20686565 19060906) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 20686565 20864672 19060911) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24386095) Metabolic syndrome ( 30382898) Metabolite levels ( 22916037) Postprandial triglyceride levels ( 32603185) Total cholesterol levels ( 29615537 28334899 29403010) Triglyceride levels ( 26763881 32335043 32203549 29615537 28371326 28334899) Triglycerides ( 20139978 20686565 20864672 19074352 19060911 19060906 21909109 26582766 18193044 18193043)
Interacting Genes		133 interacting genes: AACS ABHD4 ACSF2 ACSM1 ALDH18A1 APOA1 APOA4 APOA5 AQP6 ARFIP1 ARFIP2 ARMC9 BIK BNIP3 CAPNS2 CD160 CD40 CD79A CLDN7 COQ8A CPLX1 CPLX4 CREB3 CYP1A1 DDA1 DHRSX ECPAS ELOVL4 ERGIC3 FAM114A1 FARS2 FCGR2A FCRL3 FERMT2 FFAR2 FNDC9 GAD1 GAD2 GJB1 GLTP GOLGA2P10 GPR42 GPX8 GTF3C1 HNRNPK HSD17B13 JAGN1 JOSD2 KASH5 KCNJ6 KCNK5 KIR3DL3 LEUTX LMNA LMO2 LNX1 LRRC4C LRRC59 MCEE MCEMP1 MCFD2 MEOX2 MFF MGST3 MIEF1 MRM1 MRRF MTERF3 MTIF3 MYG1 NDRG4 NFU1 NTAQ1 PBX3 PCNA PIMREG PITPNC1 PLIN3 PNPO POLL PPIF PPP2R3C PSCA PTPN9 RBFA REEP2 RETREG3 RHBDD1 RMDN2 RNF185 RSRC2 RUSF1 SAR1A SCARA5 SCN3B SDCBP SGCB SH3GL1 SH3GLB1 SHMT2 SLC10A6 SLC18A2 SLC30A4 SLC35H1 SLC7A14 SNX1 SPATA8 SPG21 SSX3 SSX5 STING1 STOM SUCLA2 SYNE4 SYT16 TBRG4 THAP4 TIMM44 TLCD4 TMED8 TMEM139 TMEM14B TMEM35A TMEM80 TMF1 TPD52L3 TSPAN31 TTPA TUBB TUFM VARS2 ZNF391 ZNF599	6 interacting genes: AGTRAP CMTM4 CMTM5 GPLD1 HSP90AA1 MAGEA6
Entrez ID		116173	337
HPRD ID		06986	00130
Ensembl ID		ENSG00000166091	ENSG00000110244
Uniprot IDs		Q96DZ9	P06727
PDB IDs			3S84
Enriched GO Terms of Interacting Partners?		Protein Binding Mitochondrion Mitochondrial Matrix Phosphatidylcholine-sterol O-acyltransferase Activator Activity Identical Protein Binding Lipid Binding Succinate Metabolic Process Mitochondrial Outer Membrane Membrane Endoplasmic Reticulum Membrane Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Chylomicron Phospholipid Efflux Small Molecule Biosynthetic Process Low-density Lipoprotein Particle Regulation Of Mitochondrion Organization Regulation Of Release Of Cytochrome C From Mitochondria Endoplasmic Reticulum-autophagosome Adaptor Activity Phospholipid Binding Ligase Activity	Positive Regulation Of Alkaline Phosphatase Activity Glycosylphosphatidylinositol Phospholipase D Activity CTP Binding DATP Binding Cellular Response To Triglyceride Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Histone Deacetylase Binding Positive Regulation Of High-density Lipoprotein Particle Clearance Rho GDP-dissociation Inhibitor Binding Positive Regulation Of Phosphatase Activity Negative Regulation Of Triglyceride Catabolic Process Response To Triglyceride Phospholipase D Activity Positive Regulation Of Dephosphorylation Hematopoietic Stem Cell Migration To Bone Marrow Sperm Mitochondrial Sheath Telomerase Holoenzyme Complex Assembly Angiotensin Type II Receptor Activity Positive Regulation Of Protein Catabolic Process Hematopoietic Stem Cell Migration Regulation Of Phosphatase Activity Positive Regulation Of Protein Transport Chaperone-mediated Autophagy Positive Regulation Of Cardiac Muscle Contraction Nitric-oxide Synthase Regulator Activity Inclusion Body Assembly Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding
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