CMTM5 and FERMT2

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		CMTM5	FERMT2
Description		CKLF like MARVEL transmembrane domain containing 5	FERM domain containing kindlin 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane	Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Cortex Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Cell Junction Lamellipodium Membrane I Band Cell Projection Anchoring Junction
	Molecular Function	Cytokine Activity Protein Binding	Actin Binding Integrin Binding Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Protein Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding Protein Serine/threonine Kinase Activator Activity SMAD Binding Actin Filament Binding Protein Serine/threonine Kinase Binding
	Biological Process	Chemotaxis Signal Transduction Negative Regulation Of Myoblast Differentiation	Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Integrin Activation Positive Regulation Of Integrin Activation Adherens Junction Maintenance Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Vascular Permeability Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Focal Adhesion Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Limb Development Positive Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Protein Localization To Cell Junction Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Pathways			Cell-extracellular matrix interactions RAC1 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS			Alzheimer's disease (late onset) ( 24162737) Diastolic blood pressure ( 27841878) Glaucoma (primary angle closure) ( 27064256) Intraocular pressure ( 29617998 29785010 30054594 31959993) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 30046033 32439900) Prostate cancer ( 23535732) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 28135244)
Interacting Genes		133 interacting genes: AACS ABHD4 ACSF2 ACSM1 ALDH18A1 APOA1 APOA4 APOA5 AQP6 ARFIP1 ARFIP2 ARMC9 BIK BNIP3 CAPNS2 CD160 CD40 CD79A CLDN7 COQ8A CPLX1 CPLX4 CREB3 CYP1A1 DDA1 DHRSX ECPAS ELOVL4 ERGIC3 FAM114A1 FARS2 FCGR2A FCRL3 FERMT2 FFAR2 FNDC9 GAD1 GAD2 GJB1 GLTP GOLGA2P10 GPR42 GPX8 GTF3C1 HNRNPK HSD17B13 JAGN1 JOSD2 KASH5 KCNJ6 KCNK5 KIR3DL3 LEUTX LMNA LMO2 LNX1 LRRC4C LRRC59 MCEE MCEMP1 MCFD2 MEOX2 MFF MGST3 MIEF1 MRM1 MRRF MTERF3 MTIF3 MYG1 NDRG4 NFU1 NTAQ1 PBX3 PCNA PIMREG PITPNC1 PLIN3 PNPO POLL PPIF PPP2R3C PSCA PTPN9 RBFA REEP2 RETREG3 RHBDD1 RMDN2 RNF185 RSRC2 RUSF1 SAR1A SCARA5 SCN3B SDCBP SGCB SH3GL1 SH3GLB1 SHMT2 SLC10A6 SLC18A2 SLC30A4 SLC35H1 SLC7A14 SNX1 SPATA8 SPG21 SSX3 SSX5 STING1 STOM SUCLA2 SYNE4 SYT16 TBRG4 THAP4 TIMM44 TLCD4 TMED8 TMEM139 TMEM14B TMEM35A TMEM80 TMF1 TPD52L3 TSPAN31 TTPA TUBB TUFM VARS2 ZNF391 ZNF599	9 interacting genes: APP CMTM5 CTNNB1 FBLIM1 ILK ITGB1 LIMS1 PARVA TRIM15
Entrez ID		116173	10979
HPRD ID		06986	06374
Ensembl ID		ENSG00000166091	ENSG00000073712
Uniprot IDs		Q96DZ9	Q96AC1
PDB IDs			2LGX 2LKO 2MSU 4F7H 6U4N 6XTJ
Enriched GO Terms of Interacting Partners?		Protein Binding Mitochondrion Mitochondrial Matrix Phosphatidylcholine-sterol O-acyltransferase Activator Activity Identical Protein Binding Lipid Binding Succinate Metabolic Process Mitochondrial Outer Membrane Membrane Endoplasmic Reticulum Membrane Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Chylomicron Phospholipid Efflux Small Molecule Biosynthetic Process Low-density Lipoprotein Particle Regulation Of Mitochondrion Organization Regulation Of Release Of Cytochrome C From Mitochondria Endoplasmic Reticulum-autophagosome Adaptor Activity Phospholipid Binding Ligase Activity	Anchoring Junction Focal Adhesion Cell Adhesion Cell-cell Adhesion Cell-substrate Adhesion Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Neural Precursor Cell Proliferation Regulation Of Neural Precursor Cell Proliferation Cell-matrix Adhesion Developmental Cell Growth Regulation Of Developmental Process Positive Regulation Of Signal Transduction Developmental Growth Involved In Morphogenesis Regulation Of Neurotransmitter Uptake Integrin Binding Protein Kinase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Neuroblast Proliferation Lamellipodium Cell Morphogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Heterotypic Cell-cell Adhesion Branching Involved In Ureteric Bud Morphogenesis Cell Fate Determination Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Canonical Wnt Signaling Pathway Intercalated Disc Regulation Of Neuroblast Proliferation Neuroblast Proliferation Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Junction Assembly Perinuclear Region Of Cytoplasm Cellular Response To Growth Factor Stimulus Positive Regulation Of Neural Precursor Cell Proliferation Amyloid-beta Complex Regulation Of Wnt Signaling Pathway Growth Cone Lamellipodium Synaptic Membrane Regulation Of Synapse Organization Visual Behavior Regulation Of Response To Calcium Ion Response To Growth Factor Amylin Binding Anatomical Structure Morphogenesis Positive Regulation Of Toll Signaling Pathway Visual Learning
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