SGCG and CDK8

Number of citations of the paper that reports this interaction (PMID 15546612)
109

Data Source:
BioGRID (pull down)

		SGCG	CDK8
Gene Name		sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	cyclin-dependent kinase 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Sarcoglycan Complex Integral Component Of Membrane Sarcolemma	Nucleus Nucleoplasm Mediator Complex
	Molecular Function	Protein Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity
	Biological Process	Muscle Organ Development Cardiac Muscle Tissue Development Muscle Cell Development Heart Contraction Membrane Organization	Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle
Pathways			Loss of Function of TGFBR2 in Cancer PPARA activates gene expression Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Bipolar disorder ( 21738484) Corneal structure ( 23291589) Type 2 diabetes ( 23300278)
Protein-Protein Interactions		7 interactors: APP CDK8 EP300 FLNC SGCB SGCD SSPN	29 interactors: BCL6 CCNC CCNH CDKN2B CTD CTDP1 ERCC3 ESR1 ESR2 HIST2H3C MAML1 MBP MED12 MED21 MED25 MED26 MED8 MED9 MYC NRIP1 POLR2A SGCG SMAD2 SMAD3 SMARCA4 SREBF1 SUZ12 TOP1 TP53
Entrez ID		6445	1024
HPRD ID		07039	04422
Ensembl ID		ENSG00000102683	ENSG00000132964
Uniprot IDs		Q13326	P49336
PDB IDs			3RGF 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L
Enriched GO Terms of Interacting Partners?		Muscle Structure Development Notch Signaling Pathway Muscle Cell Development Muscle Organ Development Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Fiber Development Muscle Tissue Development Histone H2B Acetylation Heart Development Synaptic Growth At Neuromuscular Junction Regulation Of Protein Binding Collateral Sprouting In Absence Of Injury N-terminal Peptidyl-lysine Acetylation Striated Muscle Cell Development Cell Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Cardiac Muscle Tissue Development Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Tubulin Deacetylation Cardiovascular System Development Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell Cycle Striated Muscle Cell Differentiation Axon Choice Point Recognition Regulation Of Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Remodeling Positive Regulation By Host Of Viral Transcription Vascular Smooth Muscle Cell Development N-terminal Protein Amino Acid Acetylation	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Viral Transcription Regulation Of Gene Expression, Epigenetic Regulation Of Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Negative Regulation Of Gene Expression, Epigenetic Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Organ Development
Tagcloud ?		accumulate alterations anaplastic astrocytoma consequence correlations cps1 genomic glial glioblastoma glioma gp2 htr4 implies inpp5a instability itgb1 kcng2 kir3dl3 lhfpl3 p16 passenger pathogenesis pde4d predominantly pros1 pten seem subtypes	absent acetyltransferase acetyltransferases cbp chromatography competent complex contains conventional directed elongation form histone homolog ii importantly interacts nonphosphorylated notably pcaf polymerase purified remodeling rna snf srb srb10 swi yeast
Tagcloud (Difference) ?		accumulate alterations anaplastic astrocytoma consequence correlations cps1 genomic glial glioblastoma glioma gp2 htr4 implies inpp5a instability itgb1 kcng2 kir3dl3 lhfpl3 p16 passenger pathogenesis pde4d predominantly pros1 pten seem subtypes	absent acetyltransferase acetyltransferases cbp chromatography competent complex contains conventional directed elongation form histone homolog ii importantly interacts nonphosphorylated notably pcaf polymerase purified remodeling rna snf srb srb10 swi yeast
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