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FEM1C and BCL2L11
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
FEM1C
BCL2L11
Gene Name
fem-1 homolog c (C. elegans)
BCL2-like 11 (apoptosis facilitator)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Mitochondrial Outer Membrane
Cytosol
Microtubule
Endomembrane System
Extrinsic Component Of Membrane
BIM-BCL-xl Complex
BIM-BCL-2 Complex
Molecular Function
Protein Binding
Microtubule Binding
Biological Process
Protein Ubiquitination
In Utero Embryonic Development
B Cell Homeostasis
B Cell Apoptotic Process
Kidney Development
Myeloid Cell Homeostasis
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell-matrix Adhesion
Spermatogenesis
Brain Development
Male Gonad Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Mammary Gland Development
Positive Regulation Of Protein Homooligomerization
Response To Endoplasmic Reticulum Stress
Tube Formation
Odontogenesis Of Dentin-containing Tooth
T Cell Homeostasis
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Ear Development
Positive Regulation Of Cell Cycle
Regulation Of Organ Growth
Neurotrophin TRK Receptor Signaling Pathway
Developmental Pigmentation
Regulation Of Developmental Pigmentation
Spleen Development
Thymus Development
Post-embryonic Organ Morphogenesis
Positive Regulation Of Apoptotic Process By Virus
Cellular Process Regulating Host Cell Cycle In Response To Virus
Thymocyte Apoptotic Process
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Apoptotic Process Involved In Embryonic Digit Morphogenesis
Positive Regulation Of Fibroblast Apoptotic Process
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Signalling by NGF
Cell death signalling via NRAGE, NRIF and NADE
Activation of BIM and translocation to mitochondria
NRAGE signals death through JNK
Programmed Cell Death
Activation of BH3-only proteins
p75 NTR receptor-mediated signalling
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Chronic lymphocytic leukemia (
18758461
)
Dehydroepiandrosterone sulphate levels (
21533175
)
Primary sclerosing cholangitis (
21151127
)
Protein-Protein Interactions
4 interactors:
BCL2L11
LZTS2
PNMA1
RPGRIP1
26 interactors:
AKT1
APP
ATP6V1G1
AURKB
BCL2
BCL2A1
BCL2L1
BCL2L2
BTK
DYNLL1
DYNLL2
FEM1C
FGL1
GNB2L1
GTF2I
MAGEA11
MAPK10
MAPK8
MAPK9
MCL1
MEX3D
RIOK3
SMARCB1
TRIM2
VDAC1
YWHAB
Entrez ID
56929
10018
HPRD ID
16384
04828
Ensembl ID
ENSG00000145780
ENSG00000153094
Uniprot IDs
Q96JP0
O43521
PDB IDs
1F95
2K7W
2NL9
2V6Q
2VM6
2WH6
2YQ6
3D7V
3FDL
3IO8
3IO9
3KJ0
3KJ1
3KJ2
4B4S
Enriched GO Terms of Interacting Partners
?
Apoptotic Process Involved In Embryonic Digit Morphogenesis
Positive Regulation Of Apoptotic Process By Virus
Positive Regulation Of Fibroblast Apoptotic Process
Kidney Development
B Cell Apoptotic Process
Post-embryonic Organ Morphogenesis
Thymocyte Apoptotic Process
Renal System Development
Positive Regulation Of Killing Of Cells Of Other Organism
Regulation Of Killing Of Cells Of Other Organism
Cellular Process Regulating Host Cell Cycle In Response To Virus
Urogenital System Development
Positive Regulation Of Protein Homooligomerization
Spindle Midzone Assembly
Modulation By Virus Of Host Process
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Microtubule Severing
Cellular Response To Virus
T Cell Apoptotic Process
Positive Regulation Of Mitochondrial Membrane Permeability
Positive Regulation Of Protein Oligomerization
Modulation By Virus Of Host Morphology Or Physiology
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Sensory Organ Development
Positive Regulation Of Apoptotic Process
Regulation Of Developmental Pigmentation
Regulation Of Fibroblast Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Apoptotic Process Involved In Morphogenesis
Killing Of Cells Of Other Organism
Positive Regulation Of Cell Death
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Apoptotic Process Involved In Development
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Protein Oligomerization
Inflammatory Response To Antigenic Stimulus
Regulation Of Mitochondrial Membrane Permeability
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Membrane Permeability
B Cell Homeostasis
T Cell Homeostasis
Regulation Of Protein Localization
Eye Photoreceptor Cell Development
Developmental Programmed Cell Death
Spleen Development
Organ Development
Photoreceptor Cell Development
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Eye Photoreceptor Cell Differentiation
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Apoptotic Process
Positive Regulation Of Apoptotic Signaling Pathway
Programmed Cell Death
Cell Death
Death
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Cell Death
Regulation Of Mitochondrion Organization
Positive Regulation Of Mitochondrion Organization
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Cell Death
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
JUN Phosphorylation
Intracellular Signal Transduction
Apoptotic Mitochondrial Changes
Regulation Of Signal Transduction
Response To Radiation
Positive Regulation Of Signal Transduction
Response To Light Stimulus
Regulation Of Signaling
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Extrinsic Apoptotic Signaling Pathway
Innate Immune Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Cellular Response To Stress
Positive Regulation Of Intracellular Transport
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Apoptotic Signaling Pathway
Response To UV
Regulation Of Establishment Of Protein Localization
Fc Receptor Signaling Pathway
Negative Regulation Of Cell Death
Immune Response-regulating Signaling Pathway
Regulation Of Neuron Death
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Defense Response
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Anoikis
Tagcloud
?
akt1
antipsychotic
atg
atg12
atg4b
atg5
atg7
autophagic
autophagosome
autophagosomes
autophagy
bak1
becn1
cdkn1a
cdkn1b
chloroquine
colocalization
dysfunctional
gabarap
henceforth
lc3b
map1lc3b
olanzapine
overtly
pmaip1
sqstm1
sy5y
trp53
unmask
Tagcloud (Difference)
?
akt1
antipsychotic
atg
atg12
atg4b
atg5
atg7
autophagic
autophagosome
autophagosomes
autophagy
bak1
becn1
cdkn1a
cdkn1b
chloroquine
colocalization
dysfunctional
gabarap
henceforth
lc3b
map1lc3b
olanzapine
overtly
pmaip1
sqstm1
sy5y
trp53
unmask
Tagcloud (Intersection)
?