FEM1C and MCM8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FEM1C	MCM8
Description		fem-1 homolog C	minichromosome maintenance 8 homologous recombination repair factor
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Chromosome MCM Complex MCM8-MCM9 Complex
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding DNA Binding Chromatin Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair DNA Damage Response Female Gamete Generation Recombinational Interstrand Cross-link Repair Male Gamete Generation Protein Stabilization Mismatch Repair Involved In Maintenance Of Fidelity Involved In DNA-dependent DNA Replication Protein Localization To Chromatin
Pathways		Neddylation	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Unwinding of DNA CDC6 association with the ORC:origin complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Conotruncal heart defects (inherited effects) ( 28468790) Response to antidepressants (symptom improvement) ( 29160301)	Breast cancer ( 29059683) Estradiol levels ( 34255042) HIV-1 viral setpoint ( 20205591) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619 22267201 26414677 29773799) Preeclampsia ( 23551011) Uterine fibroids ( 30194396 31649266)
Interacting Genes		10 interacting genes: BCL2L11 CDK5R1 CEP63 LZTS2 MALT1 MCM8 OR51B2 PNMA1 RPGRIP1 SIL1	4 interacting genes: FEM1C MCM4 MCM6 MCM7
Entrez ID		56929	84515
HPRD ID		16384	12186
Ensembl ID		ENSG00000145780	ENSG00000125885
Uniprot IDs		Q96JP0	B4DN82 Q9UJA3
PDB IDs		6LBG 6LBN 6LDP 6LE6 6LEN 6LEY 6LF0 6XKC 7JYA 8PQL 8Q7R	6L0O 7DP3 7WI7 7YOX 8S91 8S92 8S94
Enriched GO Terms of Interacting Partners?			CMG Complex Double-strand Break Repair Via Break-induced Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation DNA Replication Initiation DNA Helicase Activity Single-stranded DNA Binding Regulation Of DNA Replication Helicase Activity Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Replication DNA Strand Elongation Involved In DNA Replication Chromosome, Telomeric Region Single-stranded DNA Helicase Activity DNA Strand Elongation Double-strand Break Repair DNA Recombination ATP Hydrolysis Activity Regulation Of DNA Metabolic Process DNA Repair Chromosome DNA Metabolic Process DNA Damage Response Single-stranded 3'-5' DNA Helicase Activity Mitotic DNA Replication Mitotic DNA Replication Initiation Nuclear DNA Replication ATP Binding Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Nucleoplasm Cellular Response To Stress Hydrolase Activity Nucleotide Binding Cul2-RING Ubiquitin Ligase Complex Nucleic Acid Metabolic Process Macromolecule Metabolic Process DNA Binding Nucleobase-containing Compound Metabolic Process DNA-templated DNA Replication Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Cellular Response To Xenobiotic Stimulus Response To Stress Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Complex
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