P3H1 and SLC2A4

Number of citations of the paper that reports this interaction (PubMedID 16396496)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		P3H1	SLC2A4
Description		prolyl 3-hydroxylase 1	solute carrier family 2 member 4
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Extracellular Matrix Protein-containing Complex Extracellular Exosome	Cytoplasm Endosome Multivesicular Body Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endomembrane System Vesicle Membrane Membrane Sarcoplasmic Reticulum Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle T-tubule Cytoplasmic Vesicle Membrane Vesicle Insulin-responsive Compartment Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse
	Molecular Function	Iron Ion Binding Protein Binding Collagen Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Procollagen-proline 3-dioxygenase Activity L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity	Protein Binding D-glucose Uniporter Activity Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity
	Biological Process	Protein Folding Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Protein Hydroxylation Collagen Fibril Organization Regulation Of Ossification Negative Regulation Of Cell Growth Collagen Metabolic Process Regulation Of Protein Secretion Protein Stabilization Bone Development Negative Regulation Of Post-translational Protein Modification	Carbohydrate Metabolic Process Learning Or Memory Short-term Memory Long-term Memory Amylopectin Biosynthetic Process Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Cellular Response To Insulin Stimulus Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Response To Ethanol D-glucose Import Brown Fat Cell Differentiation Transmembrane Transport White Fat Cell Proliferation Dehydroascorbic Acid Transport Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Osmotic Stress Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Transport Across Blood-brain Barrier D-glucose Transmembrane Transport
Pathways		Collagen biosynthesis and modifying enzymes	Translocation of SLC2A4 (GLUT4) to the plasma membrane Cellular hexose transport Transcriptional regulation of white adipocyte differentiation
Drugs		Ascorbic acid Proline
Diseases		Osteogenesis imperfecta
GWAS			Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Birth weight ( 23202124 31043758) Diastolic blood pressure ( 28135244) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Liver enzyme levels (alanine transaminase) ( 33972514) Medication use (diuretics) ( 31015401) Metabolite levels ( 22286219) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Systolic blood pressure ( 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Two-hour glucose ( 34059833)
Interacting Genes		13 interacting genes: CDC42 MIR1-2 MIR107 MIR141 MIR18B MIR19A MIR19B1 MIR9-3 MIR92A1 MIRLET7A2 MIRLET7B MIRLET7I SLC2A4	40 interacting genes: ACOX1 ACTN1 ACTN4 AKT2 AP1M1 ARF3 ARFIP1 BSG C1QTNF5 CCDC116 CFL1 CREB3 CTSD DAXX DLD EHD2 ESYT2 FAR1 FKBP10 GAPDH HADH HK2 HSP90AA1 IDH2 KLHL41 LNPEP MAP1S MVP P3H1 P3H4 PDIA6 PRKAR1A PSMD7 RAB7A SERPINH1 SRFBP1 STRN3 UBA52 UBE2I UBE2N
Entrez ID		64175	6517
HPRD ID		11227	00688
Ensembl ID		ENSG00000117385	ENSG00000181856
Uniprot IDs		Q32P28	P14672
PDB IDs		8K0E 8K0F 8K0I 8K0M 8K17 8KC9	7WSM 7WSN
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Extracellular Vesicle MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process Negative Regulation Of Extracellular Matrix Organization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Regulation Of Gene Expression Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Macromolecule Biosynthetic Process Regulation Of Sprouting Angiogenesis Negative Regulation Of Inflammatory Response Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Translation Regulation Of Extracellular Matrix Organization Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Extracellular Matrix Assembly Regulation Of Matrix Metallopeptidase Secretion Cellular Response To Bacterial Lipopeptide Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration Regulation Of Macromolecule Metabolic Process Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death MRNA Destabilization Negative Regulation Of Defense Response Extracellular Space RNA Destabilization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Regulation Of Angiogenesis Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Migration Regulation Of Vasculature Development	Extracellular Exosome Perinuclear Region Of Cytoplasm Regulation Of Establishment Of Protein Localization Pseudopodium Catabolic Process Collagen Fibril Organization Regulation Of Protein Localization Regulation Of Protein Secretion Regulation Of Transport Cytosol Response To Unfolded Protein Regulation Of Protein Transport Melanosome Cellular Localization Actin Cytoskeleton Organization Cytoplasm Ficolin-1-rich Granule Lumen Oxidoreductase Activity Cortical Actin Cytoskeleton Intracellular Transport Regulation Of Matrix Metallopeptidase Secretion Regulation Of Secretion By Cell Organelle Organization Actin Filament-based Process Collagen Biosynthetic Process Positive Regulation Of Transport Intracellular Protein Localization Establishment Of Protein Localization Protein Metabolic Process Regulation Of Secretion Collagen Metabolic Process Collagen Binding Macromolecule Catabolic Process Protein Catabolic Process Pyruvate Metabolic Process Protein Hydroxylation Monocarboxylic Acid Metabolic Process Protein Transport Response To Peptide Hormone Ubiquitin Protein Ligase Binding 2-oxoglutarate Metabolic Process Generation Of Precursor Metabolites And Energy Fatty Acid Derivative Metabolic Process Protein Localization To Plasma Membrane Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Actin Filament Binding Very Long-chain Fatty Acid Beta-oxidation Cytoskeleton Organization Positive Regulation Of Cell Motility
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