NECAB1 and ATOX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NECAB1	ATOX1
Description		N-terminal EF-hand calcium binding protein 1	antioxidant 1 copper chaperone
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cilium	Cytosol
	Molecular Function	Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding	Copper Ion Binding Protein Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding Metal Ion Binding ATPase Binding Cuprous Ion Binding
	Biological Process	Blastocyst Hatching Regulation Of Amyloid Precursor Protein Biosynthetic Process	Monoatomic Ion Transport Copper Ion Transport Intracellular Copper Ion Homeostasis Response To Oxidative Stress Negative Regulation Of Apoptotic Process Copper Ion Export
Pathways			Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface
Drugs			Cisplatin Sucrose Benzamidine
Diseases
GWAS		Age at first sexual intercourse ( 34211149)	Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Red cell distribution width ( 32888494) Systolic blood pressure change trajectory ( 27980656)
Interacting Genes		19 interacting genes: AP1M1 APP ATOX1 BHLHA9 BRPF1 CDC37 CPNE4 CPNE7 CPNE8 DAPK1 DISC1 FMNL2 LNX1 MORF4L1 PAX4 PCNT SNX11 TCEA2 TCEANC	9 interacting genes: ATP7A ATP7B CFAP410 COMP FAM118A FKBP4 GGPS1 NECAB1 TRAF4
Entrez ID		64168	475
HPRD ID		16851	03779
Ensembl ID		ENSG00000123119	ENSG00000177556
Uniprot IDs		Q8N987	O00244
PDB IDs			1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX 4QOT 4YDX 4YEA 5F0W 5T7L 7DC1 7ZC3
Enriched GO Terms of Interacting Partners?		Cellular Response To Metal Ion Calcium-dependent Phospholipid Binding Cellular Response To Calcium Ion Intracellular Copper Ion Homeostasis Copper Ion Homeostasis	Copper Ion Transport P-type Divalent Copper Transporter Activity P-type Monovalent Copper Transporter Activity Copper-dependent Protein Binding Copper Ion Export Copper Ion Import Copper Ion Transmembrane Transporter Activity Copper Ion Transmembrane Transport ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Perinuclear Region Of Cytoplasm Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Copper Ion Binding Skin Development Collagen Fibril Organization Steroid Hormone Receptor Complex Assembly Geranylgeranyl Diphosphate Biosynthetic Process Prenyl Diphosphate Synthase Activity Geranylgeranyl Diphosphate Synthase Activity Geranyl Diphosphate Biosynthetic Process (2E,6E)-farnesyl Diphosphate Synthase Activity Dimethylallyltranstransferase Activity Cartilage Development Trans-Golgi Network Membrane Superoxide Dismutase Copper Chaperone Activity Geranyl Diphosphate Metabolic Process P-type Ion Transporter Activity Epinephrine Metabolic Process Tendon Development Cartilage Homeostasis Male Sex Differentiation Farnesyl Diphosphate Biosynthetic Process Negative Regulation Of Catecholamine Metabolic Process Sequestering Of Calcium Ion Late Endosome Metal Ion Transport Farnesyl Diphosphate Metabolic Process Pyramidal Neuron Development Viral Translational Frameshifting
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