NECAB1 and CPNE8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NECAB1	CPNE8
Description		N-terminal EF-hand calcium binding protein 1	copine 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cilium	Plasma Membrane Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding	Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding
	Biological Process	Blastocyst Hatching Regulation Of Amyloid Precursor Protein Biosynthetic Process	Cellular Response To Calcium Ion Positive Regulation Of Dendrite Extension
Pathways			CDC42 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Arterial stiffness index ( 31235810) Bipolar disorder ( 28115744) Bisphosphonate-associated atypical femoral fracture ( 31006051) Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 25673413) Body size at age 10 ( 32376654) Chronotype ( 30696823) Heart rate ( 23583979) Heart rate response to recovery post exercise ( 29769521) Irritable bowel syndrome ( 29626450) Morning person ( 30696823) Resting heart rate ( 29769521)
Interacting Genes		19 interacting genes: AP1M1 APP ATOX1 BHLHA9 BRPF1 CDC37 CPNE4 CPNE7 CPNE8 DAPK1 DISC1 FMNL2 LNX1 MORF4L1 PAX4 PCNT SNX11 TCEA2 TCEANC	3 interacting genes: NECAB1 NEIL3 SORBS3
Entrez ID		64168	144402
HPRD ID		16851	16747
Ensembl ID		ENSG00000123119	ENSG00000139117
Uniprot IDs		Q8N987	Q86YQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Metal Ion Calcium-dependent Phospholipid Binding Cellular Response To Calcium Ion Intracellular Copper Ion Homeostasis Copper Ion Homeostasis	Depurination MCM Complex Binding Positive Regulation Of Potassium Ion Export Across Plasma Membrane Activation Of Blood Coagulation Via Clotting Cascade Calcium Activated Phosphatidylserine Scrambling Calcium Activated Phospholipid Scrambling Calcium Activated Phosphatidylcholine Scrambling Phosphatidylserine Exposure On Blood Platelet Vinculin Binding Cell-substrate Junction Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Bubble DNA Binding Single Strand Break Repair DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity DNA N-glycosylase Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Negative Regulation Of Cell Volume Calcium-activated Cation Channel Activity Regulation Of Potassium Ion Export Across Plasma Membrane Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Chloride Channel Activity Positive Regulation Of Phagocytosis, Engulfment Bleb Assembly Base-excision Repair, AP Site Formation Intracellularly Calcium-gated Chloride Channel Activity Regulation Of Amyloid Precursor Protein Biosynthetic Process Phospholipid Scramblase Activity Pore Complex Assembly Plasma Membrane Phospholipid Scrambling Positive Regulation Of Monocyte Chemotaxis Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Blastocyst Hatching Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Blood Coagulation DNA Modification Positive Regulation Of Coagulation Regulation Of Monocyte Chemotaxis Positive Regulation Of Potassium Ion Transport
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