NECAB1 and FMNL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NECAB1	FMNL2
Description		N-terminal EF-hand calcium binding protein 1	formin like 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cilium	Cytoplasm Cytosol
	Molecular Function	Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding	Actin Binding Small GTPase Binding Cadherin Binding Actin Filament Binding
	Biological Process	Blastocyst Hatching Regulation Of Amyloid Precursor Protein Biosynthetic Process	Cytoskeleton Organization Regulation Of Cell Shape Cell Migration Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization
Pathways			RHO GTPases Activate Formins RHOC GTPase cycle CDC42 GTPase cycle
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149)	Asthma (childhood onset) ( 27611488) Corneal astigmatism ( 30306274) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 29891935 33627673) Heel bone mineral density ( 30598549) Intraocular pressure ( 29235454 29617998 29785010 30054594 31959993) Lymphocyte count ( 32888494) Refractive astigmatism ( 30306274) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) White blood cell count ( 32888494)
Interacting Genes		19 interacting genes: AP1M1 APP ATOX1 BHLHA9 BRPF1 CDC37 CPNE4 CPNE7 CPNE8 DAPK1 DISC1 FMNL2 LNX1 MORF4L1 PAX4 PCNT SNX11 TCEA2 TCEANC	15 interacting genes: AP1B1 AP2B1 APP CCDC197 CDC42 KRT27 LCOR MIPOL1 NECAB1 NRIP1 PKNOX1 PNMA1 PRPF40A SUOX TTC3
Entrez ID		64168	114793
HPRD ID		16851	13545
Ensembl ID		ENSG00000123119	ENSG00000157827
Uniprot IDs		Q8N987	Q96PY5
PDB IDs			4YC7
Enriched GO Terms of Interacting Partners?		Cellular Response To Metal Ion Calcium-dependent Phospholipid Binding Cellular Response To Calcium Ion Intracellular Copper Ion Homeostasis Copper Ion Homeostasis
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