NCAPG and DNMT3B

Number of citations of the paper that reports this interaction (PubMedID 15148359)
71

Data Source:
HPRD (in vivo, in vitro)

		NCAPG	DNMT3B
Description		non-SMC condensin I complex subunit G	DNA methyltransferase 3 beta
Image
GO Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Condensed Chromosome Condensed Nuclear Chromosome Condensin Complex Nucleus Chromosome Cytoplasm Cytosol Membrane	Nucleus Nucleoplasm Catalytic Complex
	Molecular Function	Protein Binding	DNA Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding Methyltransferase Activity Zinc Ion Binding DNA-methyltransferase Activity Transferase Activity Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates
	Biological Process	Mitotic Chromosome Condensation Chromosome Condensation Cell Division Positive Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression Methylation
Pathways		Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes	PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis
Drugs			Decitabine
Diseases			Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 18391951 20189936 25429064 34270706) Hip circumference adjusted for BMI ( 34021172) Lung volume ( 34128465) Metabolite levels ( 23823483)	Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 28334935) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Nicotine dependence ( 28972577) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Total cholesterol levels ( 30275531)
Interacting Genes		4 interacting genes: CDK1 DNMT3B HSF2 SUMO2	39 interacting genes: BAZ2A BUD23 CBX1 CBX3 CBX5 CMTM6 CUL4B DDB1 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 H3C1 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS1 ZBTB18
Entrez ID		64151	1789
HPRD ID		12097	04209
Ensembl ID		ENSG00000109805	ENSG00000088305
Uniprot IDs		Q9BPX3	A0A8Q3SIG2 Q9UBC3
PDB IDs		6IGX	3FLG 3QKJ 5CIU 5NR3 5NRR 5NRS 5NRV 5NV0 5NV2 5NV7 5NVO 6KDA 6KDB 6KDL 6KDP 6KDT 6PA7 6R3E 6U8P 6U8V 6U8W 6U8X 6U90 6U91 7O45 7V0E 7X9D 8EIH 8EII 8EIJ 8EIK 8XEE
Enriched GO Terms of Interacting Partners?		Pronuclear Fusion Mitotic DNA-templated DNA Replication Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Cyclin-dependent Protein Kinase Activity DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates DNA-methyltransferase Activity DNA (cytosine-5-)-methyltransferase Activity Thymidine Metabolic Process Golgi Disassembly Regulation Of Schwann Cell Differentiation Regulation Of Transcription By RNA Polymerase II Nuclear DNA Replication Thymidine Biosynthetic Process Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Histone Kinase Activity Protein Localization To Ciliary Transition Zone Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Biosynthetic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cilium Organization Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Mitotic Nuclear Membrane Disassembly Cilium Disassembly Pyrimidine Nucleoside Metabolic Process Protein Localization To Kinetochore MKS Complex Regulation Of Metaphase Plate Congression DNA Strand Resection Involved In Replication Fork Processing Nuclear Membrane Disassembly Protein Tag Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Membrane Disassembly SUMO Transferase Activity Embryonic Brain Development Regulation Of RNA Metabolic Process Nuclear Envelope Organization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Peptidyl-threonine Phosphorylation Microtubule Cytoskeleton Organization Microtubule Polymerization Catalytic Complex	Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Heterochromatin Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Pericentric Heterochromatin Constitutive Heterochromatin Formation Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Silencing Complex Negative Regulation Of RNA Metabolic Process Facultative Heterochromatin Formation Epigenetic Programming Of Gene Expression Nucleoplasm Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation ESC/E(Z) Complex Negative Regulation Of Metabolic Process DNA Damage Response Cellular Response To Stress Regulation Of Gene Expression RDNA Heterochromatin Formation Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Rhythmic Process Chromosome, Centromeric Region Regulation Of Macromolecule Metabolic Process Chromosome Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Chromosome, Telomeric Region Epigenetic Programming In The Zygotic Pronuclei Regulation Of Chromosome Condensation Regulation Of Primary Metabolic Process Chromosomal DNA Methylation Maintenance Following DNA Replication Condensed Nuclear Chromosome Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity NoRC Complex Methylation
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