NCAPG and DNMT3B

Number of citations of the paper that reports this interaction (PMID 15148359)
36

Data Source:
HPRD (in vivo, in vitro)

		NCAPG	DNMT3B
Gene Name		non-SMC condensin I complex, subunit G	DNA (cytosine-5-)-methyltransferase 3 beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensin Complex Nucleus Cytoplasm Centrosome Cytosol Actin Cytoskeleton Membrane	Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Unmethylated CpG Binding Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates
	Biological Process	Mitotic Cell Cycle Mitotic Chromosome Condensation Cell Division	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Methylation-dependent Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Response To Ionizing Radiation DNA Methylation On Cytosine Within A CG Sequence Gene Expression Positive Regulation Of Gene Expression Protein Complex Localization DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Response To Drug Positive Regulation Of Neuron Differentiation Negative Regulation Of Gene Expression, Epigenetic S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine
Pathways		Mitotic Prometaphase Cell Cycle, Mitotic M Phase Condensation of Prometaphase Chromosomes	NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA DNA methylation
Drugs
Diseases
GWAS		Height ( 18391951 20189936)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		3 interactors: CDK1 DNMT3B HSF2	35 interactors: BAZ2A CBX1 CBX3 CBX5 CMTM6 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS ZBTB18
Entrez ID		64151	1789
HPRD ID		12097	04209
Ensembl ID		ENSG00000109805	ENSG00000088305
Uniprot IDs		Q9BPX3	Q9UBC3
PDB IDs			3FLG 3QKJ
Enriched GO Terms of Interacting Partners?		Pronuclear Fusion Positive Regulation Of Gene Expression S-adenosylmethioninamine Metabolic Process DNA Methylation On Cytosine Within A CG Sequence Regulation Of Transcription From RNA Polymerase II Promoter C-5 Methylation Of Cytosine S-adenosylhomocysteine Metabolic Process Regulation Of Schwann Cell Differentiation Methylation-dependent Chromatin Silencing Protein Localization To Kinetochore Cellular Response To Organonitrogen Compound Positive Regulation Of Cellular Metabolic Process Protein Localization To Chromosome, Centromeric Region Response To Drug Positive Regulation Of Protein Import Into Nucleus, Translocation Negative Regulation Of Histone H3-K9 Methylation DNA Methylation On Cytosine Chromatin Modification Positive Regulation Of Histone H3-K4 Methylation Regulation Of Protein Import Into Nucleus, Translocation Mitotic G2 DNA Damage Checkpoint Protein Complex Localization Ventricular Cardiac Muscle Cell Development Negative Regulation Of Histone Methylation Regulation Of Neurogenesis Chromatin Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Copper Ion Regulation Of Histone H3-K4 Methylation Positive Regulation Of Metabolic Process Sexual Reproduction Regulation Of Gene Expression By Genetic Imprinting Response To Organonitrogen Compound Ventricular Cardiac Muscle Cell Differentiation Protein Localization To Chromosome Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Cell Development G2 DNA Damage Checkpoint Positive Regulation Of Protein Modification Process Chromatin Silencing Genetic Imprinting Mitotic Nuclear Envelope Disassembly Positive Regulation Of Heart Growth Positive Regulation Of Histone Methylation Histone Phosphorylation Nuclear Envelope Disassembly Chromosome Organization Regulation Of Cardiac Muscle Cell Proliferation Reproduction DNA Metabolic Process	Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process DNA Modification Chromatin Modification Chromosome Organization Chromatin Silencing Chromatin Organization Gene Silencing Nucleobase-containing Compound Metabolic Process DNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Cellular Metabolic Process Methylation Transcription, DNA-templated Histone H3-K9 Modification Chromatin Remodeling RNA Metabolic Process DNA Methylation On Cytosine Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Histone Modification Peptidyl-lysine Modification Histone H4 Deacetylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Rhythmic Process DNA Packaging Regulation Of Gene Expression By Genetic Imprinting Hypermethylation Of CpG Island C-5 Methylation Of Cytosine
Tagcloud ?		annotations birc5 cdca2 cdh3 cited1 dhfr esco2 gins1 gins4 hells mc1r melana melanocyte melanocytes melk msg ncaph nusap1 oca2 pax3 pbk rad54l recapitulate revolutionized segregating subclasses tyms unsupervised	cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Difference) ?		annotations birc5 cdca2 cdh3 cited1 dhfr esco2 gins1 gins4 hells mc1r melana melanocyte melanocytes melk msg ncaph nusap1 oca2 pax3 pbk rad54l recapitulate revolutionized segregating subclasses tyms unsupervised	cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Intersection) ?