LIN7B and MPP7

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		LIN7B	MPP7
Description		lin-7 cell polarity scaffold B	MAGUK p55 scaffold protein 7
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GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Synapse Postsynaptic Membrane Anchoring Junction MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Membrane Lateral Plasma Membrane Cell Junction Anchoring Junction MPP7-DLG1-LIN7 Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity	Protein Binding Protein Domain Specific Binding Signaling Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	Exocytosis Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Transport Synaptic Vesicle Transport	Establishment Of Cell Polarity Positive Regulation Of Protein-containing Complex Assembly Bicellular Tight Junction Assembly Protein Localization To Adherens Junction
Pathways		Dopamine Neurotransmitter Release Cycle RHO GTPases Activate Rhotekin and Rhophilins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS			Achilles tendon injury ( 33606446) Blood protein levels ( 30072576) Bone mineral density ( 24249740) Bone mineral density (paediatric, skull) ( 24945404) Diverticular disease ( 30177863) Femur bone mineral density x serum urate levels interaction ( 34046847) Glaucoma (primary open-angle) ( 27001270) Heel bone mineral density ( 28869591 30598549) Hippocampal volume ( 21116278) Lumbar spine bone mineral density ( 22504420 29499414) Macular thickness ( 30535121) Obesity-related traits ( 23251661) Psychosis and Alzheimer's disease ( 22005930)
Interacting Genes		19 interacting genes: ABCA1 APBA1 ASIC3 BAIAP2 CASK DLG4 ENKD1 GNG13 GRIK2 GRIN2B KCNJ12 KCNJ4 MAK16 MPP7 NTAQ1 PSMB1 SNCA TCEANC TRAPPC12	7 interacting genes: DLGAP4 HSBP1 LIN7A LIN7B LIN7C MYSM1 TRIM5
Entrez ID		64130	143098
HPRD ID		10040	14733
Ensembl ID		ENSG00000104863	ENSG00000150054
Uniprot IDs		Q9HAP6	Q5T2T1
PDB IDs		2DKR	3LRA 3O46
Enriched GO Terms of Interacting Partners?		Modulation Of Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Plasticity PDZ Domain Binding Regulation Of Long-term Neuronal Synaptic Plasticity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Membrane Potential Regulation Of Nervous System Process Ligand-gated Ion Channel Signaling Pathway Cellular Component Assembly Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Protein-containing Complex Assembly Glutamate-gated Calcium Ion Channel Activity Excitatory Postsynaptic Potential Plasma Membrane Synapse Synaptic Membrane Scaffold Protein Binding Positive Regulation Of Protein-containing Complex Assembly Regulation Of Monoatomic Ion Transport Regulation Of Protein-containing Complex Assembly Protein-containing Complex Organization Protein Localization To Cell Junction Postsynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Protein Tetramerization Postsynaptic Density Schaffer Collateral - CA1 Synapse Regulation Of Postsynaptic Membrane Potential Neuron Projection Terminus Postsynaptic Density Membrane Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Regulation Of Monoatomic Ion Transmembrane Transport Inward Rectifier Potassium Channel Activity Regulation Of System Process Dendrite Cytoplasm Monoatomic Ion Transport Synaptic Vesicle Metal Ion Transport Regulation Of Presynaptic Membrane Potential Cell-cell Signaling Excitatory Synapse Ligand-gated Monoatomic Ion Channel Activity	MPP7-DLG1-LIN7 Complex Regulation Of Synaptic Assembly At Neuromuscular Junction Synaptic Vesicle Transport L27 Domain Binding Neurotransmitter Secretion Protein-macromolecule Adaptor Activity Establishment Of Organelle Localization Regulation Of Synapse Organization Neurotransmitter Transport Postsynaptic Density Membrane Establishment Of Vesicle Localization Vesicle Localization Bicellular Tight Junction Organelle Localization Signal Release Regulation Of Synapse Assembly Cell-cell Junction Exocytosis Presynapse Postsynaptic Membrane Basolateral Plasma Membrane Regulation Of Cell Junction Assembly Regulation Of Developmental Growth Synapse Secretion By Cell Anchoring Junction Omegasome Secretion Regulation Of Developmental Process Regulation Of Growth Establishment Of Localization In Cell Cellular Heat Acclimation Histone H2A Deubiquitinase Activity Protein Domain Specific Binding Cholinergic Synapse Postsynaptic Specialization Metal-dependent Deubiquitinase Activity Transcription Coactivator Activity Axonal Transport Of Mitochondrion Suppression Of Viral Release By Host Protein Transport Modification Of Postsynaptic Structure Morphogenesis Of An Epithelial Sheet Regulation Of Hair Follicle Development Regulation Of Viral Entry Into Host Cell Vesicle-mediated Transport Modification Of Synaptic Structure Host-mediated Suppression Of Symbiont Invasion Mitochondrion Transport Along Microtubule Regulation Of Cellular Component Organization
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