LIN7B and MAK16

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LIN7B	MAK16
Description		lin-7 cell polarity scaffold B	MAK16 homolog
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GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Synapse Postsynaptic Membrane Anchoring Junction MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane	Nucleus Nucleolus Preribosome, Large Subunit Precursor
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity	RNA Binding Protein Binding
	Biological Process	Exocytosis Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Transport Synaptic Vesicle Transport	Maturation Of 5.8S RRNA Maturation Of LSU-rRNA
Pathways		Dopamine Neurotransmitter Release Cycle RHO GTPases Activate Rhotekin and Rhophilins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs
Diseases
GWAS			Pulse pressure ( 30224653)
Interacting Genes		19 interacting genes: ABCA1 APBA1 ASIC3 BAIAP2 CASK DLG4 ENKD1 GNG13 GRIK2 GRIN2B KCNJ12 KCNJ4 MAK16 MPP7 NTAQ1 PSMB1 SNCA TCEANC TRAPPC12	3 interacting genes: CSNK2A1 FRMD6 LIN7B
Entrez ID		64130	84549
HPRD ID		10040	15223
Ensembl ID		ENSG00000104863	ENSG00000198042
Uniprot IDs		Q9HAP6	Q9BXY0
PDB IDs		2DKR	8FKP 8FKR 8FKT 8FKV
Enriched GO Terms of Interacting Partners?		Modulation Of Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Plasticity PDZ Domain Binding Regulation Of Long-term Neuronal Synaptic Plasticity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Membrane Potential Regulation Of Nervous System Process Ligand-gated Ion Channel Signaling Pathway Cellular Component Assembly Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Protein-containing Complex Assembly Glutamate-gated Calcium Ion Channel Activity Excitatory Postsynaptic Potential Plasma Membrane Synapse Synaptic Membrane Scaffold Protein Binding Positive Regulation Of Protein-containing Complex Assembly Regulation Of Monoatomic Ion Transport Regulation Of Protein-containing Complex Assembly Protein-containing Complex Organization Protein Localization To Cell Junction Postsynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Protein Tetramerization Postsynaptic Density Schaffer Collateral - CA1 Synapse Regulation Of Postsynaptic Membrane Potential Neuron Projection Terminus Postsynaptic Density Membrane Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Regulation Of Monoatomic Ion Transmembrane Transport Inward Rectifier Potassium Channel Activity Regulation Of System Process Dendrite Cytoplasm Monoatomic Ion Transport Synaptic Vesicle Metal Ion Transport Regulation Of Presynaptic Membrane Potential Cell-cell Signaling Excitatory Synapse Ligand-gated Monoatomic Ion Channel Activity	Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy MPP7-DLG1-LIN7 Complex Cytoplasmic Side Of Apical Plasma Membrane Apical Constriction Intracellular Protein Localization Aggrephagy Double-strand Break Repair Via Classical Nonhomologous End Joining Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Synaptic Assembly At Neuromuscular Junction MRNA Methylguanosine-cap Decapping Regulation Of Growth RNA Decapping Positive Regulation Of Hippo Signaling Sin3-type Complex PcG Protein Complex Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Execution Phase Of Apoptosis Protein Localization To Site Of Double-strand Break Apical Junction Complex
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