GGT6 and ENTPD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GGT6	ENTPD3
Description		gamma-glutamyltransferase 6	ectonucleoside triphosphate diphosphohydrolase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Protein Binding Transferase Activity Acyltransferase Activity Hydrolase Activity Glutathione Hydrolase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity	Nucleotide Binding Apyrase Activity GDP Phosphatase Activity Protein Binding ATP Binding Hydrolase Activity Nucleoside Diphosphate Phosphatase Activity Ribonucleoside Triphosphate Phosphatase Activity UDP Phosphatase Activity
	Biological Process	Glutathione Metabolic Process Glutathione Biosynthetic Process Leukotriene D4 Biosynthetic Process	Nucleoside Diphosphate Catabolic Process Nucleoside Triphosphate Catabolic Process
Pathways		Glutathione synthesis and recycling Aflatoxin activation and detoxification Paracetamol ADME	Phosphate bond hydrolysis by NTPDase proteins
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 28118524) Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) ( 28118524)	Eosinophil percentage of white cells ( 32888494) Neuroticism ( 29255261)
Interacting Genes		10 interacting genes: ADAM33 BMP10 ENTPD3 FAIM2 FAM3C GRINA NOTCH3 SEC22A TMBIM1 TNMD	16 interacting genes: ARL13B CREB3L1 ERGIC3 FAM209A FNDC9 GGT6 GPA33 IFNGR2 LEUTX LHFPL5 LMNA MUC1 PTPN5 STX2 SYNE4 TMEM106A
Entrez ID		124975	956
HPRD ID		08293	16014
Ensembl ID		ENSG00000167741	ENSG00000168032
Uniprot IDs		B4DKN3 B4DPG6 J3KPJ0 Q6P531 Q6ZPD7	O75355
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Calcium Channel Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Calcium Ion Transmembrane Transport Golgi Membrane Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Calcium Ion Transport Apoptotic Signaling Pathway Negative Regulation Of Fas Signaling Pathway Apyrase Activity Regulation Of Apoptotic Signaling Pathway Endoplasmic Reticulum Cerebellar Granular Layer Development	Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Membrane Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Epithelial Cell Polarity
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