GGT6

Gene Name		gamma-glutamyltransferase 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Anchored Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Gamma-glutamyltransferase Activity Glutathione Hydrolase Activity
	Biological Process	Proteolysis Glutathione Metabolic Process Glutathione Biosynthetic Process Leukotriene Biosynthetic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Aflatoxin activation and detoxification Glutathione synthesis and recycling Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Glutathione conjugation Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective ACY1 causes encephalopathy Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: NOTCH3
Entrez ID		124975
HPRD ID		08293
Ensembl ID		ENSG00000167741
Uniprot IDs		J3KPJ0 Q6P531 Q6ZPD7
PDB IDs
Enriched GO Terms of Interacting Partners?		Glomerular Capillary Formation Glomerulus Morphogenesis Notch Receptor Processing Glomerulus Vasculature Development Positive Regulation Of Smooth Muscle Cell Proliferation Glomerulus Development Neuron Fate Commitment Regulation Of Smooth Muscle Cell Proliferation Notch Signaling Pathway Nephron Development Transcription Initiation From RNA Polymerase II Promoter
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